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View Structure Prediction Details

Protein: ATG4
Organism: Saccharomyces cerevisiae
Length: 494 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ATG4.

Description E-value Query
Range
Subject
Range
ATG4_YEAS7 - Cysteine protease ATG4 OS=Saccharomyces cerevisiae (strain YJM789) GN=ATG4 PE=3 SV=1
ATG4_YEAST - Cysteine protease ATG4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ATG4 PE=1 SV=2
gi|190409197 - gi|190409197|gb|EDV12462.1| anchor protein [Saccharomyces cerevisiae RM11-1a]
ATG4 - Conserved cysteine protease required for autophagy; cleaves Atg8p to a form required for autophagoso...
0.0 [1..494] [1..494]
ATG4_ASHGO - Probable cysteine protease ATG4 OS=Ashbya gossypii GN=ATG4 PE=3 SV=1
ATG4_ASHGO - Probable cysteine protease ATG4 OS=Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRR...
0.0 [2..464] [43..498]
ATG4A - ATG4 autophagy related 4 homolog A (S. cerevisiae)
0.0 [60..413] [17..382]
gi|148675648, gi... - gi|27763985|emb|CAD43221.1| autophagin-2 [Mus musculus], gi|148675648|gb|EDL07595.1| mCG64870 [Mus m...
0.0 [60..413] [17..379]
ATG4A_BOVIN - Cysteine protease ATG4A OS=Bos taurus GN=ATG4A PE=2 SV=1
0.0 [60..413] [17..382]
ATG4_PODAS - Probable cysteine protease ATG4 OS=Podospora anserina GN=ATG4 PE=3 SV=1
0.0 [60..406] [144..492]
ATG4_NEUCR - Probable cysteine protease atg-4 OS=Neurospora crassa GN=atg-4 PE=3 SV=1
ATG4_NEUCR - Cysteine protease 1 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / F...
0.0 [63..406] [145..498]

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Predicted Domain #1
Region A:
Residues: [1-143]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQRWLQLWKM DLVQKVSHGV FEGSSEEPAA LMNHDYIVLG EVYPERDEES GAEQCEQDCR  60
   61 YRGEAVSDGF LSSLFGREIS SYTKEFLLDV QSRVNFTYRT RFVPIARAPD GPSPLSLNLL 120
  121 VRTNPISTIE DYIANPDCFN TDI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
peptidase activity 2.8192612691912 bayes_pls_golite062009
cysteine-type peptidase activity 2.71117522993364 bayes_pls_golite062009
hydrolase activity 2.66167923792227 bayes_pls_golite062009
endopeptidase activity 2.56654871607946 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 2.55227247835105 bayes_pls_golite062009
cytoskeletal protein binding 2.13397229861051 bayes_pls_golite062009
cysteine-type endopeptidase activity 1.95802900199539 bayes_pls_golite062009
tubulin binding 1.85112496470487 bayes_pls_golite062009
microtubule binding 1.82320858139311 bayes_pls_golite062009
small conjugating protein-specific protease activity 1.48823471197032 bayes_pls_golite062009
binding 1.34325419334831 bayes_pls_golite062009
protein binding 1.08139200376412 bayes_pls_golite062009
catalytic activity 1.05972260874031 bayes_pls_golite062009
ubiquitin-specific protease activity 0.954652694395915 bayes_pls_golite062009
transporter activity 0.69523261160023 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.467924587720185 bayes_pls_golite062009
transmembrane transporter activity 0.439003000540428 bayes_pls_golite062009
structural molecule activity 0.297752217869698 bayes_pls_golite062009
nucleic acid binding 0.289910308044519 bayes_pls_golite062009
substrate-specific transporter activity 0.125654358663332 bayes_pls_golite062009
transferase activity 0.0852393573521809 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0241561776323942 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [144-298]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GWGCMIRTGQ SLLGNALQIL HLGRDFRVNG NESLERESKF VNWFNDTPEA PFSLHNFVSA  60
   61 GTELSDKRPG EWFGPAATAR SIQSLIYGFP ECGIDDCIVS VSSGDIYENE VEKVFAENPN 120
  121 SRILFLLGVK LGINAVNESY RESICGILSS TQSVG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [299-393]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IAGGRPSSSL YFFGYQGNEF LHFDPHIPQP AVEDSFVESC HTSKFGKLQL SEMDPSMLIG  60
   61 ILIKGEKDWQ QWKLEVAESA IINVLAKRMD DFDVS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [394-494]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CSMDDVESVS SNSMKKDASN NENLGVLEGD YVDIGAIFPH TTNTEDVDEY DCFQDIHCKK  60
   61 QKIVVMGNTH TVNANLTDYE VEGVLVEKET VGIHSPIDEK C

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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Created and Maintained by: Michael Riffle