| Protein: | RPA135 |
| Organism: | Saccharomyces cerevisiae |
| Length: | 1203 amino acids |
| Reference: | Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RPA135.
| Description | E-value | Query Range |
Subject Range |
|
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0.0 | [8..1174] | [21..1170] |
|
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0.0 | [19..1171] | [7..1174] |
|
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0.0 | [10..1201] | [14..1179] |
|
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0.0 | [18..1202] | [13..1208] |
|
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0.0 | [3..1161] | [9..1109] |
|
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0.0 | [26..1148] | [81..1189] |
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0.0 | [16..1154] | [2..1170] |
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0.0 | [9..1174] | [16..1164] |
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0.0 | [7..1200] | [14..1134] |
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0.0 | [5..1177] | [1..1159] |
|
Region A: Residues: [1-895] |
1 11 21 31 41 51
| | | | | |
1 MSKVIKPPGQ ARTADFRTLE RESRFINPPK DKSAFPLLQE AVQPHIGSFN ALTEGPDGGL 60
61 LNLGVKDIGE KVIFDGKPLN SEDEISNSGY LGNKLSVSVE QVSIAKPMSN DGVSSAVERK 120
121 VYPSESRQRL TSYRGKLLLK LKWSVNNGEE NLFEVRDCGG LPVMLQSNRC HLNKMSPYEL 180
181 VQHKEESDEI GGYFIVNGIE KLIRMLIVQR RNHPMAIIRP SFANRGASYS HYGIQIRSVR 240
241 PDQTSQTNVL HYLNDGQVTF RFSWRKNEYL VPVVMILKAL CHTSDREIFD GIIGNDVKDS 300
301 FLTDRLELLL RGFKKRYPHL QNRTQVLQYL GDKFRVVFQA SPDQSDLEVG QEVLDRIVLV 360
361 HLGKDGSQDK FRMLLFMIRK LYSLVAGECS PDNPDATQHQ EVLLGGFLYG MILKEKIDEY 420
421 LQNIIAQVRM DINRGMAINF KDKRYMSRVL MRVNENIGSK MQYFLSTGNL VSQSGLDLQQ 480
481 VSGYTVVAEK INFYRFISHF RMVHRGSFFA QLKTTTVRKL LPESWGFLCP VHTPDGSPCG 540
541 LLNHFAHKCR ISTQQSDVSR IPSILYSLGV APASHTFAAG PSLCCVQIDG KIIGWVSHEQ 600
601 GKIIADTLRY WKVEGKTPGL PIDLEIGYVP PSTRGQYPGL YLFGGHSRML RPVRYLPLDK 660
661 EDIVGPFEQV YMNIAVTPQE IQNNVHTHVE FTPTNILSIL ANLTPFSDFN QSPRNMYQCQ 720
721 MGKQTMGTPG VALCHRSDNK LYRLQTGQTP IVKANLYDDY GMDNFPNGFN AVVAVISYTG 780
781 YDMDDAMIIN KSADERGFGY GTMYKTEKVD LALNRNRGDP ITQHFGFGND EWPKEWLEKL 840
841 DEDGLPYIGT YVEEGDPICA YFDDTLNKTK IKTYHSSEPA YIEEVNLIGD ESNKF
|
| Detection Method: |  |
Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.
Found no structure predictions for this domain.
| Term | Confidence | Notes |
| DNA-directed RNA polymerase activity | 10.2021663255698 | bayes_pls_golite062009 |
| RNA polymerase activity | 10.2021663255698 | bayes_pls_golite062009 |
| nucleotidyltransferase activity | 7.6240729546188 | bayes_pls_golite062009 |
| general RNA polymerase II transcription factor activity | 6.31198922553685 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 5.44374972993429 | bayes_pls_golite062009 |
| transferase activity | 4.83218811360621 | bayes_pls_golite062009 |
| transcription regulator activity | 2.34884279395902 | bayes_pls_golite062009 |
| DNA binding | 2.02586687916169 | bayes_pls_golite062009 |
| nucleic acid binding | 1.91447180328254 | bayes_pls_golite062009 |
| binding | 1.53568146966362 | bayes_pls_golite062009 |
| RNA polymerase II transcription mediator activity | 1.53259746846673 | bayes_pls_golite062009 |
| catalytic activity | 1.36406839864424 | bayes_pls_golite062009 |
| RNA binding | 1.12618950637766 | bayes_pls_golite062009 |
| RNA polymerase II transcription factor activity | 0.847783043631028 | bayes_pls_golite062009 |
| protein binding | 0.35192339064931 | bayes_pls_golite062009 |
|
Region A: Residues: [896-977] |
1 11 21 31 41 51
| | | | | |
1 QELQTVSIKY RIRRTPQIGD KFSSRHGQKG VCSRKWPTID MPFSETGIQP DIIINPHAFP 60
61 SRMTIGMFVE SLAGKAGALH GI
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| Detection Method: | |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
| MCM Score |
SCOP Match |
SCOP Description | ||
| View | Download | 0.582 | d.51.1 | Eukaryotic type KH-domain (KH-domain type I) |
| View | Download | 0.677 | d.129.1 | TATA-box binding protein-like |
| View | Download | 0.681 | a.60.2 | RuvA domain 2-like |
| View | Download | 0.552 | a.36.1 | Signal peptide-binding domain |
| View | Download | 0.450 | d.58.11 | EF-G/eEF-2 domains III and V |
| View | Download | 0.442 | d.58.4 | Dimeric alpha+beta barrel |
| View | Download | 0.392 | a.60.4 | DNA repair protein Rad51, N-terminal domain |
| View | Download | 0.384 | a.4.12 | TrpR-like |
| View | Download | 0.358 | d.74.1 | Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH) |
| View | Download | 0.355 | d.14.1 | Ribosomal protein S5 domain 2-like |
| View | Download | 0.349 | d.58.5 | GlnB-like |
| View | Download | 0.338 | d.58.17 | Metal-binding domain |
| View | Download | 0.309 | a.112.1 | Description not found. |
| View | Download | 0.301 | a.60.11 | Hypothetical protein YjbJ |
| View | Download | 0.291 | a.1.1 | Globin-like |
| View | Download | 0.288 | b.1.1 | Immunoglobulin |
| View | Download | 0.282 | d.58.7 | RNA-binding domain, RBD |
| View | Download | 0.267 | d.14.1 | Ribosomal protein S5 domain 2-like |
| View | Download | 0.255 | c.47.2 | RNA 3'-terminal phosphate cyclase, RPTC, insert domain |
| View | Download | 0.255 | a.165.1 | Myosin phosphatase inhibitor 17kDa protein, CPI-17 |
| View | Download | 0.253 | a.4.13 | Sigma3 and sigma4 domains of RNA polymerase sigma factors |
| View | Download | 0.253 | d.58.14 | Ribosomal protein S6 |
| View | Download | 0.252 | d.58.35 | Pseudouridine synthase |
| View | Download | 0.248 | a.4.1 | Homeodomain-like |
| View | Download | 0.242 | d.16.1 | FAD-linked reductases, C-terminal domain |
| View | Download | 0.235 | a.4.6 | C-terminal effector domain of the bipartite response regulators |
| View | Download | 0.235 | a.74.1 | Cyclin-like |
| View | Download | 0.200 | d.58.44 | Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains |
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Region A: Residues: [978-1071] |
1 11 21 31 41 51
| | | | | |
1 AQDSTPWIFN EDDTPADYFG EQLAKAGYNY HGNEPMYSGA TGEELRADIY VGVVYYQRLR 60
61 HMVNDKFQVR STGPVNSLTM QPVKGRKRHG GIRV
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| Detection Method: | |
Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.
| MCM Score |
GO Score |
GO Term |
SCOP Match |
SCOP Description | ||
| View | Download | 0.711 | 0.215 | DNA-directed RNA polymerase I complex | a.77.1 | DEATH domain |
| View | Download | 0.368 | 0.022 | DNA-directed RNA polymerase I complex | d.150.1 | 4'-phosphopantetheinyl transferase |
| View | Download | 0.407 | 0.008 | DNA-directed RNA polymerase I complex | a.54.1 | Domain of early E2A DNA-binding protein, ADDBP |
| View | Download | 0.425 | N/A | N/A | a.77.1 | DEATH domain |
| View | Download | 0.324 | N/A | N/A | a.29.4 | RecG, N-terminal domain |
| View | Download | 0.324 | N/A | N/A | d.38.1 | Thioesterase/thiol ester dehydrase-isomerase |
| View | Download | 0.320 | N/A | N/A | a.47.2 | t-snare proteins |
| View | Download | 0.315 | N/A | N/A | a.118.11 | Cytochrome c oxidase subunit E |
| View | Download | 0.302 | N/A | N/A | a.130.1 | Chorismate mutase II |
| View | Download | 0.298 | N/A | N/A | f.34.1 | Mechanosensitive channel protein MscS (YggB), transmembrane region |
| View | Download | 0.295 | N/A | N/A | a.100.1 | 6-phosphogluconate dehydrogenase C-terminal domain-like |
| View | Download | 0.282 | N/A | N/A | a.112.1 | Description not found. |
| View | Download | 0.276 | N/A | N/A | a.118.1 | ARM repeat |
| View | Download | 0.259 | N/A | N/A | a.158.1 | F-box domain |
| View | Download | 0.202 | N/A | N/A | d.58.7 | RNA-binding domain, RBD |
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Region A: Residues: [1072-1203] |
1 11 21 31 41 51
| | | | | |
1 GEMERDALIG HGTSFLLQDR LLNSSDYTQA SVCRECGSIL TTQQSVPRIG SISTVCCRRC 60
61 SMRFEDAKKL LTKSEDGEKI FIDDSQIWED GQGNKFVGGN ETTTVAIPFV LKYLDSELSA 120
121 MGIRLRYNVE PK
|
| Detection Method: | |
Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.
| MCM Score |
GO Score |
GO Term |
SCOP Match |
SCOP Description | ||
| View | Download | 0.404 | 0.136 | DNA-directed RNA polymerase I complex | c.23.5 | Flavoproteins |
| View | Download | 0.483 | 0.018 | DNA-directed RNA polymerase I complex | d.58.20 | NAD-binding domain of HMG-CoA reductase |
| View | Download | 0.381 | 0.014 | DNA-directed RNA polymerase I complex | a.24.15 | FAD-dependent thiol oxidase |
| View | Download | 0.490 | N/A | N/A | c.23.12 | Formate/glycerate dehydrogenase catalytic domain-like |
| View | Download | 0.359 | N/A | N/A | a.24.4 | Hemerythrin |
| View | Download | 0.359 | N/A | N/A | a.24.3 | Cytochromes |
| View | Download | 0.349 | N/A | N/A | c.44.1 | Phosphotyrosine protein phosphatases I |
| View | Download | 0.339 | N/A | N/A | c.51.3 | B12-dependend dehydatases associated subunit |
| View | Download | 0.310 | N/A | N/A | a.29.5 | alpha-ketoacid dehydrogenase kinase, N-terminal domain |
| View | Download | 0.306 | N/A | N/A | c.78.2 | Aspartate/glutamate racemase |
| View | Download | 0.291 | N/A | N/A | c.23.5 | Flavoproteins |
| View | Download | 0.285 | N/A | N/A | d.82.2 | Frataxin-like |
| View | Download | 0.276 | N/A | N/A | c.2.1 | NAD(P)-binding Rossmann-fold domains |
| View | Download | 0.268 | N/A | N/A | d.58.44 | Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains |
| View | Download | 0.251 | N/A | N/A | d.199.1 | DNA-binding C-terminal domain of the transcription factor MotA |
| View | Download | 0.243 | N/A | N/A | d.58.8 | Viral DNA-binding domain |
| View | Download | 0.238 | N/A | N/A | c.37.1 | P-loop containing nucleoside triphosphate hydrolases |
| View | Download | 0.234 | N/A | N/A | d.52.7 | Ribosome-binding factor A, RbfA |
| View | Download | 0.222 | N/A | N/A | a.24.17 | Group V grass pollen allergen |
| View | Download | 0.210 | N/A | N/A | a.24.12 | Outer surface protein C (OspC) |
