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View Structure Prediction Details

Protein: MMT2
Organism: Saccharomyces cerevisiae
Length: 449 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MMT2.

Description E-value Query
Range
Subject
Range
MMT2 - Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt1p
9.0E-94 [1..449] [1..449]
CG31860-PA - This gene is referred to in FlyBase by the symbol Dmel\CG31860 (CG31860, FBgn0051860). It is a prote...
8.0E-64 [34..441] [209..617]
gi|28628306 - gi|28628306|gb|AAO38709.1| cation diffusion facilitator 10 [Stylosanthes hamata]
8.0E-61 [28..439] [20..409]
gi|24308633, gi|... - gi|34902312|ref|NP_912502.1| Unknown protein [Oryza sativa (japonica cultivar-group)], gi|24308633|g...
2.0E-59 [26..439] [15..411]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
6.0E-59 [32..439] [8..395]
MTP10_ARATH - Metal tolerance protein 10 OS=Arabidopsis thaliana GN=MTP10 PE=2 SV=1
6.0E-59 [32..439] [38..425]
gi|21107476, gi|... - gi|21242070|ref|NP_641652.1| cobalt-zinc-cadmium resistance protein [Xanthomonas axonopodis pv. citr...
2.0E-58 [102..441] [1..286]

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Predicted Domain #1
Region A:
Residues: [1-116]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRISIDSIK QFGSFVTGYN NTSYHAAGRA IRTSSLYSTM ISANPRRCLH SSKLLNKEGQ  60
   61 EEGYNEQLIS KMSSQNGSNS RQNESEGKKE GKASSVKSLL QHTHSHSHTH MHDNPL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [117-449]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSLNVQQIKK NPGVRITWIG LASNVGMAVG KFVGGITFHS QALLADSVHA LSDLVSDFLT  60
   61 LFSVQYASRK PTSEYPYGYG KVETVGSLAV STILAMAGIS IGWSSLCAIV GPVIPHAILE 120
  121 SMAGLIGETH SHSQSLTQQA TNVNAVWIAA GSILVKEWVF QATKKVAIQT NSNVLMANAW 180
  181 HHRVDSLTSL VALVAITSSY FFNIQSLDNL GGLVVSGLII KTGGQGILSS LKELVDQSIP 240
  241 PTDPRYLEIE SVIKDSIGSL KTDLDLKQSL HVRDLTILAS GPNLRATTTL EVPVLHSGQE 300
  301 VGIRFLENAI STIREDLRMK VPNVGRWTSS LLM

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 40.79588
Match: PF01545
Description: Cation efflux family

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
cation transmembrane transporter activity 6.60087208506814 bayes_pls_golite062009
ion transmembrane transporter activity 6.49419690808578 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 6.066906606566 bayes_pls_golite062009
transporter activity 4.27173462293249 bayes_pls_golite062009
substrate-specific transporter activity 4.19993137135137 bayes_pls_golite062009
transmembrane transporter activity 4.18558383943492 bayes_pls_golite062009
efflux transmembrane transporter activity 2.65640147236 bayes_pls_golite062009
metal ion transmembrane transporter activity 2.5985956122288 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 2.19343183150052 bayes_pls_golite062009
cation channel activity 2.19094036108769 bayes_pls_golite062009
ion channel activity 2.03125515494926 bayes_pls_golite062009
substrate-specific channel activity 1.95530036989194 bayes_pls_golite062009
passive transmembrane transporter activity 1.95111816239105 bayes_pls_golite062009
channel activity 1.95111816239105 bayes_pls_golite062009
binding 1.27456652114636 bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity 0.775439159437009 bayes_pls_golite062009
active transmembrane transporter activity 0.490905558612378 bayes_pls_golite062009
protein binding 0.311357063667067 bayes_pls_golite062009
transition metal ion transmembrane transporter activity 0.255026640963499 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle