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View Structure Prediction Details

Protein: TRE1
Organism: Saccharomyces cerevisiae
Length: 783 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TRE1.

Description E-value Query
Range
Subject
Range
gi|207340661 - gi|207340661|gb|EDZ68943.1| YPL176Cp-like protein [Saccharomyces cerevisiae AWRI1631]
TRE1_YEAST - Uncharacterized protein TRE1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TRE1 PE=1 S...
TRE1 - Plasma membrane protein that binds to Bsd2p and regulates ubiquitylation and vacuolar degradation of...
0.0 [1..783] [1..783]
gi|31982728, gi|... - gi|31982728|ref|NP_056614.2| transferrin receptor 2 [Mus musculus], gi|15559221|gb|AAH13654.1| Trfr2...
0.0 [31..781] [20..797]
TFR2 - transferrin receptor 2
0.0 [31..781] [20..800]

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Predicted Domain #1
Region A:
Residues: [1-136]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVNTRGYTTL PNVEEPANNS QDELNSQDFE QAIGMPSEPP VYVEEMGMEE PQAPEAFSEK  60
   61 VQRFRMCFEN NVVIPVKKNV VDPLAQMISL ASEKFDLFLS KIGNVMVMRR IFYIMMMSII 120
  121 AALIIASDRL PNGKAR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [137-209]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSNGSFSDHD LLLQYARKSI DLSKIERDLE YISSMPHMSG TSGDAAIRHY IKESFDKNGI  60
   61 RLAGEEEFMA YSN

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [322-348]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QYGTGDALTP EWEGSIRDPI DATEAKC

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [398-619]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IRERHPVHDI VGKIEGSEQA GRAIVIAAPR NSASYGTMYP SFGTVVLLSL IQLYQEMVYK  60
   61 FDWKPLRNIY FISFGGSEFN EAGATELMEK RTEALKSEIY TIIDVGQIGI WDDSNNLEIQ 120
  121 CHPLLVDLFQ KNMTSRKFNV KVDNVHQFGD WTPYLAQGIP VAIISSPGVM NREHPIYTVE 180
  181 DKFDFIKDKL RDKKKGEVLS EIMLYLVEKS LELIDDPFIP FS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 277.54902
Match: 1de4C_
Description: Transferrin receptor ectodomain, C-terminal domain; Transferrin receptor ectodomain, apical domain; Transferrin receptor ectodomain, protease-like domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 3.26568153906254 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 2.98334117181651 bayes_pls_golite062009
hydrolase activity 2.9250662598192 bayes_pls_golite062009
transmembrane receptor activity 2.06300314555202 bayes_pls_golite062009
signal transducer activity 1.98411113807388 bayes_pls_golite062009
molecular transducer activity 1.98411113807388 bayes_pls_golite062009
receptor activity 1.93707013781136 bayes_pls_golite062009
metallopeptidase activity 1.75261723003176 bayes_pls_golite062009
exopeptidase activity 1.5759162922092 bayes_pls_golite062009
catalytic activity 1.3989281287879 bayes_pls_golite062009
transferrin receptor activity 1.08060244646522 bayes_pls_golite062009
carboxypeptidase activity 0.891655769761122 bayes_pls_golite062009
binding 0.700980045216992 bayes_pls_golite062009
metalloexopeptidase activity 0.472688733072762 bayes_pls_golite062009
metallocarboxypeptidase activity 0.180859448845431 bayes_pls_golite062009
aminopeptidase activity 0.0966237570696103 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [210-321]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YPGNVSLRVY SKDDTEGFDI PLNEENFNPM SHNGQLNNIP VIYANKASLD DMASMQDQGL  60
   61 LNGDFILLVH YGDYVFQQML TAQEYGAKAI IFISEPYQDN KDVIQMKSVA LP

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [349-397]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPKIPSIPIS ANQGDKILAI LSDTGVKFSN NLFSGSLNDC RLDLLVQTA

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [620-783]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ISNYVDFLST TLKDLQKECP DTVNFDEVFL GTTLWENTKL QFEKWKSEWT ELMYGAGTYI  60
   61 EPTIIAINRW SWNYLLSLIG VTQCLEEGLM DRTFYKNVIF GPKLWVDKGD PLRSWTFPEI 120
  121 RDTIAIKDWS SVQVQANTLG TILQNTARYF LENKNLHGIN TNEF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 277.54902
Match: 1de4C_
Description: Transferrin receptor ectodomain, C-terminal domain; Transferrin receptor ectodomain, apical domain; Transferrin receptor ectodomain, protease-like domain
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle