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View Structure Prediction Details

Protein: TRE1
Organism: Saccharomyces cerevisiae
Length: 783 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TRE1.

Description E-value Query
Range
Subject
Range
gi|207340661 - gi|207340661|gb|EDZ68943.1| YPL176Cp-like protein [Saccharomyces cerevisiae AWRI1631]
TRE1_YEAST - Uncharacterized protein TRE1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TRE1 PE=1 S...
TRE1 - Plasma membrane protein that binds to Bsd2p and regulates ubiquitylation and vacuolar degradation of...
0.0 [1..783] [1..783]
gi|31982728, gi|... - gi|31982728|ref|NP_056614.2| transferrin receptor 2 [Mus musculus], gi|15559221|gb|AAH13654.1| Trfr2...
0.0 [31..781] [20..797]
TFR2 - transferrin receptor 2
0.0 [31..781] [20..800]

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Predicted Domain #1
Region A:
Residues: [1-136]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVNTRGYTTL PNVEEPANNS QDELNSQDFE QAIGMPSEPP VYVEEMGMEE PQAPEAFSEK  60
   61 VQRFRMCFEN NVVIPVKKNV VDPLAQMISL ASEKFDLFLS KIGNVMVMRR IFYIMMMSII 120
  121 AALIIASDRL PNGKAR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.581 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.621 d.79.2 Tubulin/Dihydroxyacetone kinase C-terminal domain
View Download 0.621 d.79.2 Tubulin/Dihydroxyacetone kinase C-terminal domain
View Download 0.581 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.567 a.48.1 N-terminal domain of cbl (N-cbl)
View Download 0.567 a.48.1 N-terminal domain of cbl (N-cbl)
View Download 0.567 d.79.2 Tubulin/Dihydroxyacetone kinase C-terminal domain
View Download 0.537 a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.537 a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.499 a.63.1 Apolipophorin-III
View Download 0.493 a.25.2 Thermoplasma ferritin-like 4-helical bundle
View Download 0.487 a.24.3 Cytochromes
View Download 0.485 a.7.8 GAT domain
View Download 0.473 a.24.9 alpha-catenin/vinculin
View Download 0.451 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.450 a.24.3 Cytochromes
View Download 0.446 f.31.1 Photosystem I reaction center subunit XI, PsaL
View Download 0.443 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.435 a.62.1 Hepatitis B viral capsid (hbcag)
View Download 0.412 a.138.1 Multiheme cytochromes
View Download 0.410 a.24.3 Cytochromes
View Download 0.398 a.24.1 Apolipoprotein
View Download 0.392 f.18.1 F1F0 ATP synthase subunit A
View Download 0.364 a.5.4 Elongation factor TFIIS domain 2
View Download 0.352 a.47.2 t-snare proteins
View Download 0.350 a.29.5 alpha-ketoacid dehydrogenase kinase, N-terminal domain
View Download 0.333 a.78.1 Fatty acid responsive transcription factor FadR, C-terminal domain
View Download 0.332 f.13.1 Family A G protein-coupled receptor-like
View Download 0.311 a.47.2 t-snare proteins
View Download 0.297 f.21.2 Fumarate reductase respiratory complex transmembrane subunits
View Download 0.291 a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.278 a.24.11 Bacterial GAP domain
View Download 0.276 a.121.1 Tetracyclin repressor-like, C-terminal domain
View Download 0.267 a.63.1 Apolipophorin-III
View Download 0.266 a.26.1 4-helical cytokines
View Download 0.266 f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.263 a.24.9 alpha-catenin/vinculin
View Download 0.262 d.67.3 Ribosome recycling factor, RRF
View Download 0.247 a.172.1 Helical scaffold and wing domains of SecA
View Download 0.244 a.26.1 4-helical cytokines
View Download 0.240 d.6.1 Prion-like
View Download 0.234 a.24.4 Hemerythrin
View Download 0.225 a.1.1 Globin-like
View Download 0.224 a.1.1 Globin-like
View Download 0.224 c.80.1 SIS domain
View Download 0.224 a.7.7 BAG domain
View Download 0.222 a.19.1 Fertilization protein
View Download 0.220 i.11.1 Computational models partly based on NMR data
View Download 0.220 a.2.6 Effector domain of the protein kinase pkn/prk1
View Download 0.219 a.1.1 Globin-like
View Download 0.215 a.24.14 FAT domain of focal adhesion kinase
View Download 0.212 a.133.1 Phospholipase A2, PLA2
View Download 0.210 d.87.2 CO dehydrogenase flavoprotein C-terminal domain-like
View Download 0.207 a.25.1 Ferritin-like
View Download 0.207 d.195.1 YopH tyrosine phosphatase N-terminal domain
View Download 0.205 a.73.1 Retrovirus capsid protein, N-terminal core domain
View Download 0.201 a.170.1 BRCA2 helical domain

Predicted Domain #2
Region A:
Residues: [137-209]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSNGSFSDHD LLLQYARKSI DLSKIERDLE YISSMPHMSG TSGDAAIRHY IKESFDKNGI  60
   61 RLAGEEEFMA YSN

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [322-348]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QYGTGDALTP EWEGSIRDPI DATEAKC

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [398-619]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IRERHPVHDI VGKIEGSEQA GRAIVIAAPR NSASYGTMYP SFGTVVLLSL IQLYQEMVYK  60
   61 FDWKPLRNIY FISFGGSEFN EAGATELMEK RTEALKSEIY TIIDVGQIGI WDDSNNLEIQ 120
  121 CHPLLVDLFQ KNMTSRKFNV KVDNVHQFGD WTPYLAQGIP VAIISSPGVM NREHPIYTVE 180
  181 DKFDFIKDKL RDKKKGEVLS EIMLYLVEKS LELIDDPFIP FS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 277.54902
Match: 1de4C_
Description: Transferrin receptor ectodomain, C-terminal domain; Transferrin receptor ectodomain, apical domain; Transferrin receptor ectodomain, protease-like domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 3.26568153906254 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 2.98334117181651 bayes_pls_golite062009
hydrolase activity 2.9250662598192 bayes_pls_golite062009
transmembrane receptor activity 2.06300314555202 bayes_pls_golite062009
signal transducer activity 1.98411113807388 bayes_pls_golite062009
molecular transducer activity 1.98411113807388 bayes_pls_golite062009
receptor activity 1.93707013781136 bayes_pls_golite062009
metallopeptidase activity 1.75261723003176 bayes_pls_golite062009
exopeptidase activity 1.5759162922092 bayes_pls_golite062009
catalytic activity 1.3989281287879 bayes_pls_golite062009
transferrin receptor activity 1.08060244646522 bayes_pls_golite062009
carboxypeptidase activity 0.891655769761122 bayes_pls_golite062009
binding 0.700980045216992 bayes_pls_golite062009
metalloexopeptidase activity 0.472688733072762 bayes_pls_golite062009
metallocarboxypeptidase activity 0.180859448845431 bayes_pls_golite062009
aminopeptidase activity 0.0966237570696103 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [210-321]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YPGNVSLRVY SKDDTEGFDI PLNEENFNPM SHNGQLNNIP VIYANKASLD DMASMQDQGL  60
   61 LNGDFILLVH YGDYVFQQML TAQEYGAKAI IFISEPYQDN KDVIQMKSVA LP

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [349-397]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPKIPSIPIS ANQGDKILAI LSDTGVKFSN NLFSGSLNDC RLDLLVQTA

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [620-783]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ISNYVDFLST TLKDLQKECP DTVNFDEVFL GTTLWENTKL QFEKWKSEWT ELMYGAGTYI  60
   61 EPTIIAINRW SWNYLLSLIG VTQCLEEGLM DRTFYKNVIF GPKLWVDKGD PLRSWTFPEI 120
  121 RDTIAIKDWS SVQVQANTLG TILQNTARYF LENKNLHGIN TNEF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 277.54902
Match: 1de4C_
Description: Transferrin receptor ectodomain, C-terminal domain; Transferrin receptor ectodomain, apical domain; Transferrin receptor ectodomain, protease-like domain
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle