YRC Public Data Repository - Protein Structure Prediction

Protein:	CPA1
Organism:	Saccharomyces cerevisiae
Length:	411 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CPA1.

Description	E-value	Query Range	Subject Range
CPA1 - Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulli... CARA_YEAST - Carbamoyl-phosphate synthase arginine-specific small chain OS=Saccharomyces cerevisiae (strain ATCC ...	0.0	[1..411]	[1..411]
gi\|31418608 - gi\|31418608\|gb\|AAH53097.1\| Cad protein [Mus musculus]	0.0	[8..393]	[50..424]
PYR1_MESAU - CAD protein OS=Mesocricetus auratus GN=CAD PE=1 SV=4	0.0	[8..373]	[2..360]
gi\|29136233, gi\|... - gi\|29140609\|ref\|NP_803951.1\| carbamoyl phosphate synthase small subunit [Salmonella enterica subsp. ... gi\|213650150 - gi\|213650150\|ref\|ZP_03380203.1\| carbamoyl phosphate synthase small subunit [Salmonella enterica subs... gi\|214001274 - gi\|214001274\|ref\|ZP_03412009.1\| carbamoyl phosphate synthase small subunit [Salmonella enterica subs... gi\|213419769 - gi\|213419769\|ref\|ZP_03352835.1\| carbamoyl phosphate synthase small subunit [Salmonella enterica subs... gi\|213427506 - gi\|213427506\|ref\|ZP_03360256.1\| carbamoyl phosphate synthase small subunit [Salmonella enterica subs... gi\|213163013 - gi\|213163013\|ref\|ZP_03348723.1\| carbamoyl phosphate synthase small subunit [Salmonella enterica subs...	0.0	[6..374]	[3..378]
CARA_SALTY - Carbamoyl-phosphate synthase small chain OS=Salmonella typhimurium GN=carA PE=3 SV=2 CARA_SALTY - Carbamoyl-phosphate synthase small chain OS=Salmonella typhimurium GN=carA PE=3 SV=2 gi\|167989924, gi... - gi\|205331492\|gb\|EDZ18256.1\| carbamoyl-phosphate synthase, small subunit [Salmonella enterica subsp. ... gi\|197264738, gi... - gi\|197264738\|ref\|ZP_03164812.1\| carbamoyl-phosphate synthase, small subunit [Salmonella enterica sub... lcl\|NC_016856.1_... - [gene=carA] [protein=carbamoyl phosphate synthase small subunit] [protein_id=YP_005235710.1] [locati... CARA_SALTY - Carbamoyl-phosphate synthase small chain OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700...	0.0	[6..375]	[3..379]
CARA_NOSS1 - Carbamoyl-phosphate synthase small chain OS=Nostoc sp. (strain PCC 7120 / UTEX 2576) GN=carA PE=3 SV... gi\|25291405 - pir\|\|AH1950 carbamoyl phosphate synthase small chain [imported] - Nostoc sp. (strain PCC 7120)	0.0	[3..380]	[4..386]
gi\|66819073, gi\|... - gi\|66819073\|ref\|XP_643196.1\| glutamine amidotransferase [Dictyostelium discoideum AX4], gi\|60471286\|... PYR1_DICDI - Protein PYR1-3 OS=Dictyostelium discoideum GN=pyr1-3 PE=1 SV=3	0.0	[6..405]	[7..416]
CAD - carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	0.0	[8..375]	[2..362]
CARA_SALTI - Carbamoyl-phosphate synthase small chain OS=Salmonella typhi GN=carA PE=3 SV=1 CARA_SALTI - Carbamoyl-phosphate synthase small chain OS=Salmonella typhi GN=carA PE=3 SV=1 gi\|16759059 - gi\|16759059\|ref\|NP_454676.1\| carbamoyl phosphate synthase small subunit [Salmonella enterica subsp. ...	0.0	[6..374]	[3..378]

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Predicted Domain #1

Region A:
Residues: [1-158]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSAATKATF CIQNGPSFEG ISFGANKSVA GETVFTTSLV GYPESMTDPS YRGQILVFTQ  60
   61 PLIGNYGVPS GEARDEYNLL KYFESPHIHV VGIVVAEYAY QYSHWTAVES LAQWCQREGV 120
  121 AAITGVDTRE LVQYLREQGS SLGRITLADH DPVPYVNP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	781.0
Match:	1bxrB_
Description:	Carbamoyl phosphate synthetase, small subunit N-terminal domain; Carbamoyl phosphate synthetase, small subunit C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	9.74519370915839	bayes_pls_golite062009
carbamoyl-phosphate synthase activity	9.70414577567935	bayes_pls_golite062009
carbon-nitrogen ligase activity, with glutamine as amido-N-donor	9.14496558670743	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	7.05319676113266	bayes_pls_golite062009
ligase activity	1.70348758031146	bayes_pls_golite062009
phosphoribosylformylglycinamidine synthase activity	1.51568729563523	bayes_pls_golite062009
catalytic activity	1.30391542469987	bayes_pls_golite062009
imidazoleglycerol-phosphate synthase activity	0.270391651600004	bayes_pls_golite062009
anthranilate synthase activity	0.243205818526006	bayes_pls_golite062009
nucleic acid binding	0.12569720972861	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [159-411]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKTNLVAQVT TKKPFHVSAL PGKAKANVAL IDCGVKENII RCLVKRGANV TVFPYDYRIQ  60
   61 DVASEFDGIF LSNGPGNPEL CQATISNVRE LLNNPVYDCI PIFGICLGHQ LLALASGAST 120
  121 HKLKYGNRAH NIPAMDLTTG QCHITSQNHG YAVDPETLPK DQWKPYFVNL NDKSNEGMIH 180
  181 LQRPIFSTQF HPEAKGGPLD TAILFDKFFD NIEKYQLQSQ AKSSISLKVT YSTDKSRLQS 240
  241 INVTKLAKER VLF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	781.0
Match:	1bxrB_
Description:	Carbamoyl phosphate synthetase, small subunit N-terminal domain; Carbamoyl phosphate synthetase, small subunit C-terminal domain
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: