YRC Public Data Repository - Protein Structure Prediction

Protein:	DDP1
Organism:	Saccharomyces cerevisiae
Length:	188 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DDP1.

Description	E-value	Query Range	Subject Range
gi\|190407482 - gi\|190407482\|gb\|EDV10749.1\| diadenosine and diphosphoinositol polyphosphate phosphohydrolase [Saccha... gi\|151945782 - gi\|151945782\|gb\|EDN64023.1\| diadenosine 5',5'''-P1,P4-tetraphosphate hydrolase [Saccharomyces cerevi... DDP1_YEAST - Diphosphoinositol polyphosphate phosphohydrolase DDP1 OS=Saccharomyces cerevisiae (strain ATCC 20450... DDP1 - Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyp...	1.0E-36	[1..188]	[1..188]
NUDT4_ARATH - Nudix hydrolase 4 OS=Arabidopsis thaliana GN=NUDT4 PE=1 SV=1	1.0E-25	[9..188]	[38..204]
APS1_SCHPO - Diphosphoinositol polyphosphate phosphohydrolase aps1 OS=Schizosaccharomyces pombe (strain 972 / ATC... aps1 - diadenosine 5',5'''-p1,p6-hexaphosphate hydrolase Aps1	3.0E-25	[12..187]	[22..209]
gi\|1888557 - gi\|1888557\|gb\|AAC49902.1\| diadenosine 5',5'''-P1,P4-tetraphosphate hydrolase [Lupinus angustifolius]	1.0E-21	[23..178]	[39..192]
ADPP_METJA - ADP-ribose pyrophosphatase OS=Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / ... ADPP_METJA - ADP-ribose pyrophosphatase OS=Methanocaldococcus jannaschii GN=nudF PE=1 SV=1	3.0E-21	[21..156]	[28..166]
gi\|40317634, gi\|... - gi\|7739472\|gb\|AAF68859.1\|AF191653_1 diphosphoinositol polyphosphate phosphohydrolase type 2 beta [Ho... gi\|123982768, gi... - gi\|61357443\|gb\|AAX41388.1\| nudix-type motif 4 [synthetic construct], gi\|123997437\|gb\|ABM86320.1\| nud... ENSPTRT00000009734 - null	1.0E-20	[14..182]	[1..148]
RPPH_HAEIN - RNA pyrophosphohydrolase OS=Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) GN=rp... RPPH_HAEIN, NUDH... - RNA pyrophosphohydrolase OS=Haemophilus influenzae GN=rppH PE=3 SV=2, Probable - Haemophilus influen...	3.0E-20	[29..184]	[5..154]

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Predicted Domain #1

Region A:
Residues: [1-188]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGKTADNHGP VRSETAREGR ENQVYSPVTG ARLVAGCICL TPDKKQVLMI TSSAHKKRWI  60
   61 VPKGGVEKDE PNYETTAQRE TWEEAGCIGK IVANLGTVED MRPPKDWNKD IKQFENSRKD 120
  121 SEVAKHPPRT EFHFYELEIE NLLDKFPECH KRHRKLYSYT EAKQNLIDAK RPELLEALNR 180
  181 SAIIKDDK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	21.09691
Match:	1f3yA_
Description:	Diadenosine tetraphosphate hydrolase (Ap4A hydrolase)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.49075808737475	bayes_pls_golite062009
hydrolase activity	1.08437985755037	bayes_pls_golite062009
nucleic acid binding	0.654571025500586	bayes_pls_golite062009
binding	0.648929968265004	bayes_pls_golite062009
transferase activity	0.338414890259504	bayes_pls_golite062009
protein binding	0.0607475466763231	bayes_pls_golite062009
bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity	0.0140979802606357	bayes_pls_golite062009
bis(5'-nucleosyl)-tetraphosphatase activity	0.0140979802606357	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: