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Catalysis of the reaction: P(1),P(4)-bis(5'-nucleosyl)tetraphosphate + H2O = NTP + NMP. Acts on bis(5'-guanosyl)-, bis(5'-xanthosyl)-, bis(5'-adenosyl)- and bis(5'-uridyl)-tetraphosphate. Catalysis of the hydrolysis of P(1),P(4)-bis(5'-nucleosyl)tetraphosphate into two nucleotides. Catalysis of the reaction: a dinucleotide + H2O = 2 mononucleotides.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity
Acc: GO:0004081
Aspect: Molecular Function
Desc: Catalysis of the reaction: P(1),P(4)-bis(5'-nucleosyl)tetraphosphate + H2O = NTP + NMP. Acts on bis(5'-guanosyl)-, bis(5'-xanthosyl)-, bis(5'-adenosyl)- and bis(5'-uridyl)-tetraphosphate.
Synonyms:
  • Ap4Aase activity
  • Ap4A hydrolase activity
  • diadenosine 5',5'''-P1,P4-tetraphosphate hydrolase
  • diadenosine P1,P4-tetraphosphatase activity
  • dinucleoside tetraphosphatase activity
  • diadenosinetetraphosphatase (asymmetrical) activity
  • dinucleosidetetraphosphatase (asymmetrical) activity
  • Ap(4)A hydrolase activity
  • bis(5'-adenosyl)-tetraphosphatase activity
  • Ap(4)Aase activity
  • 1-P,4-P-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase activity
  • diguanosinetetraphosphatase (asymmetrical) activity
  • bis(5'-guanosyl)-tetraphosphatase activity
  • diadenosine 5',5'''-P(1),P(4)-tetraphosphate asymmetrical hydrolase activity
  • diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase activity
  • P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase activity
Proteins in PDR annotated with:
   This term: 7 [Search]
   Term or descendants: 7 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004081 - bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity (interactive image map)

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