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View Structure Prediction Details

Protein: LSC1
Organism: Saccharomyces cerevisiae
Length: 329 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LSC1.

Description E-value Query
Range		 Subject
Range
LSC1 - Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyze...
SUCA_YEAST - Succinyl-CoA ligase [ADP-forming] subunit alpha, mitochondrial OS=Saccharomyces cerevisiae (strain A...
 0.0 [1..329] [1..329]
SUCA1_ARATH - Succinyl-CoA ligase [ADP-forming] subunit alpha-1, mitochondrial OS=Arabidopsis thaliana GN=At5g0830...
 0.0 [4..328] [29..342]
SUCA_RAT - Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial OS=Rattus norvegicus GN=Suclg1 PE=2 S...
 0.0 [9..329] [10..331]
gi|153207709, gi... - gi|153207709|ref|ZP_01946356.1| succinate-CoA ligase (ADP-forming), alpha subunit [Coxiella burnetii...
SUCD_COXBU - Succinyl-CoA ligase [ADP-forming] subunit alpha OS=Coxiella burnetii (strain RSA 493 / Nine Mile pha...
gi|212010645, gi... - gi|212212235|ref|YP_002303171.1| succinyl-CoA synthetase alpha chain [Coxiella burnetii CbuG_Q212], ...
gi|94491229, gi|... - gi|94491229|ref|ZP_01298445.1| hypothetical protein CburD_01001671 [Coxiella burnetii Dugway 7E9-12]...
gi|212013255, gi... - gi|212218993|ref|YP_002305780.1| succinyl-CoA synthetase alpha chain [Coxiella burnetii CbuK_Q154], ...
SUCD_COXBU - Succinyl-CoA ligase [ADP-forming] subunit alpha OS=Coxiella burnetii GN=sucD PE=3 SV=2
 0.0 [29..324] [1..288]
SUCA_MOUSE - Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial OS=Mus musculus GN=Suclg1 PE=1 SV=3
 0.0 [9..329] [10..331]
CE05227 - succinyl-CoA synthetase status:Confirmed UniProt:P53596 protein_id:CAA94107.1
 6.0E-98 [1..325] [1..318]

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Predicted Domain #1
Region A:
Residues: [1-160] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRSTVSKAS LKICRHFHRE SIPYDKTIKN LLLPKDTKVI FQGFTGKQGT FHASISQEYG  60
   61 TNVVGGTNPK KAGQTHLGQP VFASVKDAIK ETGATASAIF VPPPIAAAAI KESIEAEIPL 120
  121 AVCITEGIPQ HDMLYIAEML QTQDKTRLVG PNCPGIINPA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 876.491979
Match: 1eucA_
Description: Succinyl-CoA synthetase, alpha-chain, N-terminal (CoA-binding) domain; Succinyl-CoA synthetase, alpha-chain, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
succinate-CoA ligase activity 11.5979130191209 bayes_pls_golite062009
succinate-CoA ligase (GDP-forming) activity 10.9659410855563 bayes_pls_golite062009
CoA-ligase activity 10.4192804448897 bayes_pls_golite062009
acid-thiol ligase activity 10.243481928473 bayes_pls_golite062009
ligase activity, forming carbon-sulfur bonds 9.48706872092269 bayes_pls_golite062009
succinate-CoA ligase (ADP-forming) activity 9.35325976720833 bayes_pls_golite062009
malate dehydrogenase activity 4.38786524125089 bayes_pls_golite062009
oxidoreductase activity 3.09625241707629 bayes_pls_golite062009
transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer 3.07329302783164 bayes_pls_golite062009
ligase activity 2.30626698552338 bayes_pls_golite062009
catalytic activity 1.90735517755117 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor 1.70038641098437 bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors 1.65338499044318 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1.47309297191111 bayes_pls_golite062009
malic enzyme activity 1.2147813077436 bayes_pls_golite062009
transferase activity, transferring acyl groups 1.15639517822408 bayes_pls_golite062009
L-malate dehydrogenase activity 1.02646414923682 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH 0.99118526697655 bayes_pls_golite062009
ATP citrate synthase activity 0.917482134347073 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 0.576163737662951 bayes_pls_golite062009
malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity 0.120195861875768 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 0.0913823272876781 bayes_pls_golite062009
alcohol dehydrogenase (NAD) activity 0.00644214957417527 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [161-329] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TKVRIGIQPP KIFQAGKIGI ISRSGTLTYE AVQQTTKTDL GQSLVIGMGG DAFPGTDFID  60
   61 ALKLFLEDET TEGIIMLGEI GGKAEIEAAQ FLKEYNFSRS KPMPVASFIA GTVAGQMKGV 120
  121 RMGHSGAIVE GSGTDAESKK QALRDVGVAV VESPGYLGQA LLDQFAKFK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 876.491979
Match: 1eucA_
Description: Succinyl-CoA synthetase, alpha-chain, N-terminal (CoA-binding) domain; Succinyl-CoA synthetase, alpha-chain, C-terminal domain
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle