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View Structure Prediction Details

Protein: YOL098C
Organism: Saccharomyces cerevisiae
Length: 1037 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YOL098C.

Description E-value Query
Range
Subject
Range
YOL098C - Putative metalloprotease
YO098_YEAST - Uncharacterized protein YOL098C OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YOL098C ...
0.0 [1..1017] [1..1017]
gi|13477137 - gi|13477137|gb|AAH05025.1| Pitrilysin metallopeptidase 1 [Homo sapiens]
0.0 [10..1002] [53..1030]
SPAC3H1.02c - metallopeptidase
YAN2_SCHPO - Uncharacterized protein C3H1.02c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC3H1.0...
0.0 [8..1034] [10..1027]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [15..1027] [20..974]
IDE1_ARATH - Insulin-degrading enzyme-like 1, peroxisomal OS=Arabidopsis thaliana GN=PXM16 PE=2 SV=1
0.0 [21..1022] [26..949]
gi|7190249, gi|1... - gi|7190249|gb|AAF39083.1| metalloprotease, insulinase family [Chlamydia muridarum Nigg], gi|15834831...
gi|7190249, gi|1... - gi|7190249|gb|AAF39083.1| metalloprotease, insulinase family [Chlamydia muridarum Nigg], gi|15834831...
0.0 [4..1018] [12..972]
gi|237803256, gi... - gi|237803256|ref|YP_002888450.1| metalloprotease-insulinase [Chlamydia trachomatis], gi|231274490|em...
gi|3329294, gi|1... - gi|3329294|gb|AAC68421.1| Zinc Metalloprotease (insulinase family) [Chlamydia trachomatis D/UW-3/CX]...
gi|7469080 - pir||A71466 probable zinc metalloproteinase (insulinase family) - Chlamydia trachomatis (serotype D,...
gi|76168099, gi|... - gi|76789569|ref|YP_328655.1| insulinase family metalloprotease [Chlamydia trachomatis A/HAR-13], gi|...
0.0 [4..1018] [12..971]
IDE_RAT - Insulin-degrading enzyme OS=Rattus norvegicus GN=Ide PE=1 SV=1
0.0 [10..997] [57..958]

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Predicted Domain #1
Region A:
Residues: [1-158]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGFKKLVSFQ PDYVPQYHIT KYISERTKLQ LVHINHKTSP LVHGYFAVPT ECLNDSGAPH  60
   61 TLEHLIFMGS KSYPYKGLLD TAGNLSLSNT NAWTDTDQTV YTLSSAGWKG FSKLLPAYLD 120
  121 HILHPTLTDE ACLTEVYHID PENLGDKGVV FSEMEAIE

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [179-260]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GYRSETGGLT KNLRTLTNDE IRQFHKSLYS SDNLCVIVCG NVPTDELLTV MEEWDNKLPE  60
   61 IPSNIPKKRP FLDNKLSHIP QS

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [387-419]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LNYEKNGESR FSSAVITDYI YGNEDGSSLV SSL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 130.221849
Match: 1bccA_
Description: Cytochrome bc1 core subunit 1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 3.69244584360647 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 3.08483676722061 bayes_pls_golite062009
endopeptidase activity 2.95066280153013 bayes_pls_golite062009
hydrolase activity 2.42559068821325 bayes_pls_golite062009
metallopeptidase activity 2.13305051098292 bayes_pls_golite062009
metalloendopeptidase activity 1.79244321225531 bayes_pls_golite062009
binding 1.51460850438647 bayes_pls_golite062009
catalytic activity 1.30647052031202 bayes_pls_golite062009
structural molecule activity 0.389336364351523 bayes_pls_golite062009
protein binding 0.236143103582996 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [159-178]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TQGWYISGLE KQRLMFPEGS 

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [261-386]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RDKVTESTVE FPELDESQGE LLFSWIGVPY SDFRNDLAVD VLLDYFTDSA LAVFTRELVE  60
   61 IDDPMANSTD CCTDYFMRTI IDLRIQGVPT EKIAATKTKV LEILKTHTID LSRVRQVVEN 120
  121 TKWEYL

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [420-498]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KDLSDFDALL QWSQKDWQSL LNRIFVDNKP IIVTAKPSAL MYEQLEKEKS DLIKQREAEF  60
   61 DDEKKLVLLK RLNNAKNIN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 130.221849
Match: 1bccA_
Description: Cytochrome bc1 core subunit 1
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [499-550]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DRPIPKSLLQ KFEIDNPSKS VEFVNTKSIA TVDSYKYNNV SDPLTKKILE TR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [551-689]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PDNFPLFIHL NHFPSQFIEL HFLVNSASIK DTSLLPYFNM FDELFSMPMK ILDEESNVET  60
   61 MLSFEEVVAK LKSETIDAQI NQGLKGSCPD LINFKIQCRA GGYSNSVQWI KHCLFDMVFD 120
  121 ENRVRILLEN YLNSIVEWK

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [708-793]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RSLKKSTDPL FVEAKLQEIF AEIENGNFEK EILPRIETMR KQLRANFNKF HILVLGDISK  60
   61 IDDVYEPWNP LIKCLNIAHP VEKLKI

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [935-960]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IECGYFETAL SKYVDEFCLQ RGNNFN

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 14.21
Match: 1kb9A
Description: Cytochrome bc1 core subunit 1
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [690-707]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RNGNVMLSSL TNRNLYSA

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [794-934]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPVPRALDTI SSICRTPGEK AFIITTPASE SAYMNLITSI PFNLDYHDPE YAIVSLASEY  60
   61 LECVEGPFWK GIRGAGLAYG ASMLKLCEIN SWGFNIYRGA DIIKCYEVGK QIVQDYASGA 120
  121 LEFDEQLIQG AISSIINRLA T

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [961-1037]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ELYLERLQNV TKTDLKNAMQ KYFVNMFDSN KSVAFVSCHP AKLESVQEFF ETQGFTVEIE  60
   61 ELEDDDDEID SEEDENA

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 14.21
Match: 1kb9A
Description: Cytochrome bc1 core subunit 1
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle