YRC Public Data Repository - Protein Structure Prediction

Protein:	GUA1
Organism:	Saccharomyces cerevisiae
Length:	525 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GUA1.

Description	E-value	Query Range	Subject Range
gi\|460064 - gi\|460064\|emb\|CAA49847.1\| GMP synthase [Saccharomyces cerevisiae]	0.0	[1..525]	[1..525]
GUAA_BACHD - Putative GMP synthase [glutamine-hydrolyzing] OS=Bacillus halodurans GN=guaA PE=3 SV=1 GUAA_BACHD - Putative GMP synthase [glutamine-hydrolyzing] OS=Bacillus halodurans (strain ATCC BAA-125 / DSM 1819...	0.0	[13..525]	[8..513]
GUAA_HAEIN - GMP synthase [glutamine-hydrolyzing] OS=Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20... GUAA_HAEIN - GMP synthase [glutamine-hydrolyzing] OS=Haemophilus influenzae GN=guaA PE=3 SV=1	0.0	[10..525]	[5..523]
gi\|121585763, gi... - gi\|121585763\|ref\|ZP_01675558.1\| GMP synthase [Vibrio cholerae 2740-80], gi\|121550126\|gb\|EAX60142.1\| ... gi\|124120234, gi... - gi\|153220670\|ref\|ZP_01951781.1\| GMP synthase [Vibrio cholerae MAK 757], gi\|124120234\|gb\|EAY38977.1\| ... gi\|153817288, gi... - gi\|153817288\|ref\|ZP_01969955.1\| GMP synthase [Vibrio cholerae NCTC 8457], gi\|126512204\|gb\|EAZ74798.1... gi\|126521087, gi... - gi\|229510710\|ref\|ZP_04400189.1\| GMP synthase [glutamine-hydrolyzing] [Vibrio cholerae B33], gi\|22935... gi\|121631492, gi... - gi\|75815733\|ref\|ZP_00746228.1\| COG0519: GMP synthase, PP-ATPase domain/subunit [Vibrio cholerae V52]... GUAA_VIBCH - GMP synthase [glutamine-hydrolyzing] OS=Vibrio cholerae GN=guaA PE=3 SV=1 GUAA_VIBCH - GMP synthase [glutamine-hydrolyzing] OS=Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inab... GUAA_VIBCM - GMP synthase [glutamine-hydrolyzing] OS=Vibrio cholerae serotype O1 (strain M66-2) GN=guaA PE=3 SV=1 gi\|229505618, gi... - gi\|229505618\|ref\|ZP_04395128.1\| GMP synthase [glutamine-hydrolyzing] [Vibrio cholerae BX 330286], gi... gi\|229344547, gi... - gi\|229517832\|ref\|ZP_04407276.1\| GMP synthase [glutamine-hydrolyzing] [Vibrio cholerae RC9], gi\|22934... gi\|229608636, gi... - gi\|229608636\|ref\|YP_002879284.1\| GMP synthase (glutamine-hydrolyzing) [Vibrio cholerae MJ-1236], gi\|... gi\|116190771, gi... - gi\|75831989\|ref\|ZP_00761248.1\| COG0519: GMP synthase, PP-ATPase domain/subunit [Vibrio cholerae MO10... GUAA_VIBC3 - GMP synthase [glutamine-hydrolyzing] OS=Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical O...	0.0	[6..525]	[2..517]
GUAA_SALTY - GMP synthase [glutamine-hydrolyzing] OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)... GUAA_SALTY - GMP synthase [glutamine-hydrolyzing] OS=Salmonella typhimurium GN=guaA PE=3 SV=1 GUAA_SALTY - GMP synthase [glutamine-hydrolyzing] OS=Salmonella typhimurium GN=guaA PE=3 SV=1	0.0	[10..525]	[6..525]
gi\|213425340 - gi\|213425340\|ref\|ZP_03358090.1\| bifunctional GMP synthase/glutamine amidotransferase protein [Salmon... gi\|213622893 - gi\|213622893\|ref\|ZP_03375676.1\| bifunctional GMP synthase/glutamine amidotransferase protein [Salmon... gi\|213852551 - gi\|213852551\|ref\|ZP_03382083.1\| bifunctional GMP synthase/glutamine amidotransferase protein [Salmon... gi\|238913647 - gi\|238913647\|ref\|ZP_04657484.1\| GMP synthase [Salmonella enterica subsp. enterica serovar Tennessee ... gi\|214000302 - gi\|214000302\|ref\|ZP_03411037.1\| bifunctional GMP synthase/glutamine amidotransferase protein [Salmon... GUAA_SALDC - GMP synthase [glutamine-hydrolyzing] OS=Salmonella dublin (strain CT_02021853) GN=guaA PE=3 SV=1 GUAA_SALG2 - GMP synthase [glutamine-hydrolyzing] OS=Salmonella gallinarum (strain 287/91 / NCTC 13346) GN=guaA P... GUAA_SALEP - GMP synthase [glutamine-hydrolyzing] OS=Salmonella enteritidis PT4 (strain P125109) GN=guaA PE=3 SV=... gi\|213160878 - gi\|213160878\|ref\|ZP_03346588.1\| bifunctional GMP synthase/glutamine amidotransferase protein [Salmon... GUAA_SALTI - GMP synthase [glutamine-hydrolyzing] OS=Salmonella typhi GN=guaA PE=3 SV=1 gi\|205344986, gi... - gi\|205344986\|gb\|EDZ31750.1\| gmp synthase (glutamine-hydrolyzing) [Salmonella enterica subsp. enteric... GUAA_SALHS - GMP synthase [glutamine-hydrolyzing] OS=Salmonella heidelberg (strain SL476) GN=guaA PE=3 SV=1 gi\|194470386, gi... - gi\|194470386\|ref\|ZP_03076370.1\| gmp synthase (glutamine-hydrolyzing) [Salmonella enterica subsp. ent... GUAA_SALA4 - GMP synthase [glutamine-hydrolyzing] OS=Salmonella agona (strain SL483) GN=guaA PE=3 SV=1 gi\|205325488, gi... - gi\|205325488\|gb\|EDZ13327.1\| gmp synthase (glutamine-hydrolyzing) [Salmonella enterica subsp. enteric... gi\|168232074, gi... - gi\|205333635\|gb\|EDZ20399.1\| gmp synthase (glutamine-hydrolyzing) [Salmonella enterica subsp. enteric... gi\|168243285, gi... - gi\|205337568\|gb\|EDZ24332.1\| gmp synthase (glutamine-hydrolyzing) [Salmonella enterica subsp. enteric... gi\|205349448, gi... - gi\|205349448\|gb\|EDZ36079.1\| gmp synthase (glutamine-hydrolyzing) [Salmonella enterica subsp. enteric... gi\|29140876, gi\|... - gi\|29140876\|ref\|NP_804218.1\| bifunctional GMP synthase/glutamine amidotransferase protein [Salmonell... gi\|16761427 - gi\|16761427\|ref\|NP_457044.1\| bifunctional GMP synthase/glutamine amidotransferase protein [Salmonell... GUAA_SALTI - GMP synthase [glutamine-hydrolyzing] OS=Salmonella typhi GN=guaA PE=3 SV=1	0.0	[10..525]	[6..525]
GUAA_CLOPE - GMP synthase [glutamine-hydrolyzing] OS=Clostridium perfringens GN=guaA PE=3 SV=1 gi\|170663325, gi... - gi\|170663325\|gb\|EDT16008.1\| GMP synthase [Clostridium perfringens E str. JGS1987], gi\|168205103\|ref\|... gi\|168211656, gi... - gi\|170710386\|gb\|EDT22568.1\| GMP synthase [Clostridium perfringens B str. ATCC 3626], gi\|168211656\|re... gi\|110800712, gi... - gi\|110800712\|ref\|YP_696947.1\| bifunctional GMP synthase/glutamine amidotransferase protein [Clostrid... gi\|170715290, gi... - gi\|170715290\|gb\|EDT27472.1\| GMP synthase [Clostridium perfringens CPE str. F4969], gi\|168213184\|ref\|... GUAA_CLOPE - GMP synthase [glutamine-hydrolyzing] OS=Clostridium perfringens (strain 13 / Type A) GN=guaA PE=3 SV... gi\|182381223, gi... - gi\|182381223\|gb\|EDT78702.1\| GMP synthase [Clostridium perfringens NCTC 8239], gi\|168216761\|ref\|ZP_02...	0.0	[10..525]	[1..509]
gi\|195936649 - gi\|195936649\|ref\|ZP_03082031.1\| bifunctional GMP synthase/glutamine amidotransferase protein [Escher... gi\|208728135, gi... - gi\|208808334\|ref\|ZP_03250671.1\| GMP synthetase [Escherichia coli O157:H7 str. EC4206], gi\|208728135\|... gi\|208812438, gi... - gi\|208812438\|ref\|ZP_03253767.1\| GMP synthetase [Escherichia coli O157:H7 str. EC4045], gi\|208733715\|... gi\|208819837, gi... - gi\|208819837\|ref\|ZP_03260157.1\| GMP synthetase [Escherichia coli O157:H7 str. EC4042], gi\|208739960\|... GUAA_ECO5E - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=guaA PE=3... GUAA_ECOSE - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli (strain SE11) GN=guaA PE=3 SV=1 gi\|194432074, gi... - gi\|83570727\|ref\|ZP_00922170.1\| COG0519: GMP synthase, PP-ATPase domain/subunit [Shigella dysenteriae... gi\|217327698, gi... - gi\|217327698\|ref\|ZP_03443781.1\| GMP synthetase [Escherichia coli O157:H7 str. TW14588], gi\|217320065... GUAA_ECOHS - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli O9:H4 (strain HS) GN=guaA PE=3 SV=1 GUAA_ECO8A - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli O8 (strain IAI1) GN=guaA PE=3 SV=1 gi\|168761118, gi... - gi\|189368390\|gb\|EDU86806.1\| GMP synthase [Escherichia coli O157:H7 str. EC4501], gi\|168761118\|ref\|ZP... gi\|189362273, gi... - gi\|189362273\|gb\|EDU80692.1\| GMP synthase [Escherichia coli O157:H7 str. EC4486], gi\|168768599\|ref\|ZP... gi\|254794453, gi... - gi\|254794453\|ref\|YP_003079290.1\| GMP synthetase (glutamine aminotransferase) [Escherichia coli O157:... gi\|168773579, gi... - gi\|187770635\|gb\|EDU34479.1\| GMP synthase (glutamine-hydrolyzing) [Escherichia coli O157:H7 str. EC41... gi\|237705014, gi... - gi\|237705014\|ref\|ZP_04535495.1\| bifunctional GMP synthase/glutamine amidotransferase [Escherichia sp... gi\|168778473, gi... - gi\|189003283\|gb\|EDU72269.1\| GMP synthase [Escherichia coli O157:H7 str. EC4076], gi\|168778473\|ref\|ZP... gi\|227835889, gi... - gi\|227887539\|ref\|ZP_04005344.1\| bifunctional GMP synthase/glutamine amidotransferase protein [Escher... GUAA_ECOUT - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli (strain UTI89 / UPEC) GN=guaA PE=3 SV=1 gi\|168787853, gi... - gi\|189372276\|gb\|EDU90692.1\| GMP synthase [Escherichia coli O157:H7 str. EC869], gi\|168787853\|ref\|ZP_... gi\|13362839, gi\|... - gi\|15832623\|ref\|NP_311396.1\| GMP synthase [Escherichia coli O157:H7 str. Sakai], gi\|13362839\|dbj\|BAB... gi\|168798878, gi... - gi\|189378613\|gb\|EDU97029.1\| GMP synthase [Escherichia coli O157:H7 str. EC508], gi\|168798878\|ref\|ZP_... GUAA_ECOL5 - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=guaA PE=3... GUAA_ECOLC - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks) GN=g... GUAA_ECOSM - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli (strain SMS-3-5 / SECEC) GN=guaA PE=3 SV=1 GUAA_ECO45 - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=guaA PE=3 SV... GUAA_ECO81 - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli O81 (strain ED1a) GN=guaA PE=3 SV=1 GUAA_ECO55 - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli (strain 55989 / EAEC) GN=guaA PE=3 SV=1 GUAA_ECO7I - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli O7:K1 (strain IAI39 / ExPEC) GN=guaA PE=3 S... GUAA_ECOL6 - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli O6 GN=guaA PE=3 SV=1 GUAA_ECO57 - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli O157:H7 GN=guaA PE=3 SV=1 gi\|209763452, gi... - pir\|\|A91050 GMP synthetase [imported] - Escherichia coli (strain O157:H7, substrain RIMD 0509952), ... GUAA_ECOL6 - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) ... gi\|168748434, gi... - gi\|188017013\|gb\|EDU55135.1\| GMP synthase [Escherichia coli O157:H7 str. EC4113], gi\|168748434\|ref\|ZP... gi\|189356551, gi... - gi\|189356551\|gb\|EDU74970.1\| GMP synthase [Escherichia coli O157:H7 str. EC4401], gi\|168756279\|ref\|ZP... gi\|194414657, gi... - gi\|75211473\|ref\|ZP_00711563.1\| COG0519: GMP synthase, PP-ATPase domain/subunit [Escherichia coli B17... gi\|190902261, gi... - gi\|75229161\|ref\|ZP_00715733.1\| COG0519: GMP synthase, PP-ATPase domain/subunit [Escherichia coli B7A... gi\|75237747, gi\|... - gi\|75237747\|ref\|ZP_00721763.1\| COG0519: GMP synthase, PP-ATPase domain/subunit [Escherichia coli E11... gi\|190906762, gi... - gi\|75240144\|ref\|ZP_00724103.1\| COG0519: GMP synthase, PP-ATPase domain/subunit [Escherichia coli F11... gi\|75257314, gi\|... - gi\|75257314\|ref\|ZP_00728838.1\| COG0519: GMP synthase, PP-ATPase domain/subunit [Escherichia coli E22... gi\|188491634, gi... - gi\|75515847\|ref\|ZP_00737982.1\| COG0519: GMP synthase, PP-ATPase domain/subunit [Escherichia coli 536... GUAA_ECOK1 - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli O1:K1 / APEC GN=guaA PE=3 SV=1 gi\|124498700, gi... - gi\|124531254\|ref\|ZP_01701596.1\| GMP synthase, large subunit [Escherichia coli B], gi\|124498700\|gb\|EA...	0.0	[10..525]	[6..525]
gi\|253323643, gi... - gi\|254289242\|ref\|YP_003054990.1\| bifunctional GMP synthase/glutamine amidotransferase protein [Esche... gi\|251785832, gi... - gi\|251785832\|ref\|YP_003000136.1\| hypothetical protein B21_02361 [Escherichia coli BL21], gi\|24237810... GUAA_ECOBW - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli (strain K12 / MC4100 / BW2952) GN=guaA PE=3... gi\|89109313, gi\|... - gi\|89109313\|ref\|AP_003093.1\| GMP synthetase [Escherichia coli str. K-12 substr. W3110], gi\|1805567\|d... gi\|194437686, gi... - gi\|83586843\|ref\|ZP_00925474.1\| COG0519: GMP synthase, PP-ATPase domain/subunit [Escherichia coli 101... EG10420 - GMP synthetase (glutamine aminotransferase) / GMP synthase EG10420 - GMP synthetase (glutamine aminotransferase) / GMP synthase GUAA_ECOLI - GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) (Glutamine amidotransferase) (GMP synthetase) (GMP... GUAA_ECODH - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli (strain K12 / DH10B) GN=guaA PE=3 SV=1 gi\|254162481, gi... - gi\|254162481\|ref\|YP_003045589.1\| bifunctional GMP synthase/glutamine amidotransferase protein [Esche...	0.0	[10..525]	[6..525]

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Predicted Domain #1

Region A:
Residues: [1-203]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAGEQVSNM FDTILVLDFG SQYSHLITRR LREFNIYAEM LPCTQKISEL GWTPKGVILS  60
   61 GGPYSVYAED APHVDHAIFD LNVPILGICY GMQELAWING KQVGRGDKRE YGPATLKVID 120
  121 DSNSLFKGMN DSTVWMSHGD KLHGLPTGYK TIATSDNSPY CGIVHETKPI YGIQFHPEVT 180
  181 HSTQGKTLLK NFAVDLCHAK QNW

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	2510.0
Match:	1gpmA_
Description:	GMP synthetase; GMP synthetase, central domain; GMP synthetase C-terminal dimerisation domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
carbon-nitrogen ligase activity, with glutamine as amido-N-donor	2.70451256281397	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	2.33781404450996	bayes_pls_golite062009
phosphoribosylformylglycinamidine synthase activity	1.83575136996743	bayes_pls_golite062009
carbamoyl-phosphate synthase activity	1.74828881793189	bayes_pls_golite062009
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	1.74029540439985	bayes_pls_golite062009
ligase activity	1.70348758031146	bayes_pls_golite062009
catalytic activity	1.30391542469987	bayes_pls_golite062009
GMP synthase activity	0.413068109408727	bayes_pls_golite062009
anthranilate synthase activity	0.243205818526006	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [204-403]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TMENFIDTEI NRIRKLVGPT AEVIGAVSGG VDSTVASKLM TEAIGDRFHA ILVDNGVLRL  60
   61 NEAANVKKTL VEGLGINLMV VDASEEFLSK LKGVTDPEKK RKIIGNTFIH VFEREAEKIK 120
  121 PKDGKEIQFL LQGTLYPDVI ESISFKGPSQ TIKTHHNVGG LLENMKLKLI EPLRELFKDE 180
  181 VRHLGELLGI PHDLVWRHPF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	2510.0
Match:	1gpmA_
Description:	GMP synthetase; GMP synthetase, central domain; GMP synthetase C-terminal dimerisation domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [404-525]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PGPGIAIRVL GEVTKEQVEI ARKADNIYIE EIKKAGLYNQ ISQAFACLLP VKSVGVMGDQ  60
   61 RTYDQVIALR AIETTDFMTA DWFPFEHSFL KKVASRIVNE VDGVARVTYD ITSKPPATVE 120
  121 WE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	2510.0
Match:	1gpmA_
Description:	GMP synthetase; GMP synthetase, central domain; GMP synthetase C-terminal dimerisation domain
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: