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View Structure Prediction Details

Protein: IOC4
Organism: Saccharomyces cerevisiae
Length: 475 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for IOC4.

Description E-value Query
Range
Subject
Range
IOC4_YEAST - ISWI one complex protein 4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=IOC4 PE=1 SV=...
IOC4 - Member of a complex (Isw1b) with Isw1p and Ioc2p that exhibits nucleosome-stimulated ATPase activity...
5.0E-79 [1..475] [1..475]
gi|16554449, gi|... - gi|16554449|ref|NP_003377.1| zonadhesin isoform 3 [Homo sapiens], gi|12667414|gb|AAK01433.1|AF332977...
2.0E-38 [5..401] [502..936]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
2.0E-37 [3..392] [37..428]

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Predicted Domain #1
Region A:
Residues: [1-103]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEAIFQPTD IVLAKVKGFS AWPAMIIPNE LIPDNILKTK PVSVHKGKSG SDKKANEDID  60
   61 ADMESEARDR EQSEEEEDIE DFGESEANPE KFIIYTPVLK FRK

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 23.638272
Match: PF00855
Description: PWWP domain

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
binding 3.45928671861254 bayes_pls_golite062009
transcription regulator activity 3.24722861476275 bayes_pls_golite062009
histone methyltransferase activity 2.55219533482531 bayes_pls_golite062009
histone binding 2.26545558774373 bayes_pls_golite062009
DNA binding 2.10892266989425 bayes_pls_golite062009
histone-lysine N-methyltransferase activity 2.01216822303077 bayes_pls_golite062009
protein-lysine N-methyltransferase activity 2.01216822303077 bayes_pls_golite062009
lysine N-methyltransferase activity 2.01216822303077 bayes_pls_golite062009
nucleic acid binding 1.96501079412108 bayes_pls_golite062009
protein binding 1.84773537446909 bayes_pls_golite062009
protein methyltransferase activity 1.7489342678155 bayes_pls_golite062009
transcription repressor activity 1.38876191465165 bayes_pls_golite062009
transcription factor binding 1.32624006699374 bayes_pls_golite062009
transcription factor activity 1.19430233104619 bayes_pls_golite062009
methylated histone residue binding 1.1690628420074 bayes_pls_golite062009
transcription cofactor activity 1.15814615779914 bayes_pls_golite062009
N-methyltransferase activity 0.883512085043854 bayes_pls_golite062009
chromatin binding 0.563534016927931 bayes_pls_golite062009
transcription coactivator activity 0.422700451906002 bayes_pls_golite062009
transcription activator activity 0.23424395939437 bayes_pls_golite062009
transcription corepressor activity 0.0867039973523847 bayes_pls_golite062009
sequence-specific DNA binding 0.0205412614883955 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [104-418]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDTLKSTYCV KFFCDDSYIW VKPMDMKILT SEDCRKWLSG KQRKNKKLIP AYEMAMRGKN  60
   61 GIDIWEFVEY GSYGKPDEEE YVEEEEEENE PEKKAIRPTR SSSRQRQKRA SETEKSEGGN 120
  121 SNKRKRVTRS TRQQAIDASE EEEEEEEEKV QEAVRKRPQR TKTKKVVVSK TKPNPKTKAK 180
  181 KEKPKPPKPI KYHFEDDEDW SIVGLGPQDL SIEKTMDPIA KKLSQKKNLE KHVEIKLDLE 240
  241 DKLAGINKLL CDVLCSAINQ AVSIKDDFEI ILDELQIALD TRGSRNEFIT IFQSNNSLLL 300
  301 NFRILFNLRK RELNK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [419-475]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WDLWDRFQDI FKHIYSYQFI PDTEDWQLEQ NMEIEEMDRE KPSFSEDVKE EESKVGA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle