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View Structure Prediction Details

Protein: TSL1
Organism: Saccharomyces cerevisiae
Length: 1098 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TSL1.

Description E-value Query
Range
Subject
Range
TSL1_YEAST - Trehalose synthase complex regulatory subunit TSL1 OS=Saccharomyces cerevisiae (strain ATCC 204508 /...
TSL1 - Large subunit of trehalose 6-phosphate synthase (Tps1p)/phosphatase (Tps2p) complex, which converts ...
0.0 [1..1098] [1..1098]
TPS7_ARATH - Probable alpha,alpha-trehalose-phosphate synthase [UDP-forming] 7 OS=Arabidopsis thaliana GN=TPS7 PE...
0.0 [305..1097] [22..835]
gi|8131926 - gi|8131926|gb|AAF73139.1|AF148854_1 trehalose phosphate synthase subunit [Pichia angusta]
0.0 [143..1096] [32..1026]

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Predicted Domain #1
Region A:
Residues: [1-251]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALIVASLFL PYQPQFELDT SLPENSQVDS SLVNIQAMAN DQQQQRALSN NISQESLVAP  60
   61 APEQGVPPAI SRSATRSPSA FNRASSTTNT ATLDDLVSSD IFMENLTANA TTSHTPTSKT 120
  121 MLKPRKNGSV ERFFSPSSNI PTDRIASPIQ HEHDSGSRIA SPIQQQQQDP TTNLLKNVNK 180
  181 SLLVHSLLNN TSQTSLEGPN NHIVTPKSRA GNRPTSAATS LVNRTKQGSA SSGSSGSSAP 240
  241 PSIKRITPHL T

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [252-809]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ASAAKQRPLL AKQPSNLKYS ELADISSSET SSQHNESDPD DLTTAPDEEY VSDLEMDDAK  60
   61 QDYKVPKFGG YSNKSKLKKY ALLRSSQELF SRLPWSIVPS IKGNGAMKNA INTAVLENII 120
  121 PHRHVKWVGT VGIPTDEIPE NILANISDSL KDKYDSYPVL TDDDTFKAAY KNYCKQILWP 180
  181 TLHYQIPDNP NSKAFEDHSW KFYRNLNQRF ADAIVKIYKK GDTIWIHDYH LMLVPQMVRD 240
  241 VLPFAKIGFT LHVSFPSSEV FRCLAQREKI LEGLTGADFV GFQTREYARH FLQTSNRLLM 300
  301 ADVVHDEELK YNGRVVSVRF TPVGIDAFDL QSQLKDGSVM QWRQLIRERW QGKKLIVCRD 360
  361 QFDRIRGIHK KLLAYEKFLV ENPEYVEKST LIQICIGSSK DVELERQIMI VVDRINSLST 420
  421 NISISQPVVF LHQDLDFSQY LALSSEADLF VVSSLREGMN LTCHEFIVCS EDKNAPLLLS 480
  481 EFTGSASLLN DGAIIINPWD TKNFSQAILK GLEMPFDKRR PQWKKLMKDI INNDSTNWIK 540
  541 TSLQDIHISW QFNQEGSK

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 248.022276
Match: PF00982
Description: Glycosyltransferase family 20

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [810-1098]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IFKLNTKTLM EDYQSSKKRM FVFNIAEPPS SRMISILNDM TSKGNIVYIM NSFPKPILEN  60
   61 LYSRVQNIGL IAENGAYVSL NGVWYNIVDQ VDWRNDVAKI LEDKVERLPG SYYKINESMI 120
  121 KFHTENAEDQ DRVASVIGDA ITHINTVFDH RGIHAYVYKN VVSVQQVGLS LSAAQFLFRF 180
  181 YNSASDPLDT SSGQITNIQT PSQQNPSDQE QQPPASPTVS MNHIDFACVS GSSSPVLEPL 240
  241 FKLVNDEASE GQVKAGHAIV YGDATSTYAK EHVNGLNELF TIISRIIED

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 73.136677
Match: PF02358
Description: Trehalose-phosphatase

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity 11.2045941324603 bayes_pls_golite062009
glucosyltransferase activity 8.25064561355471 bayes_pls_golite062009
UDP-glucosyltransferase activity 8.0463972704113 bayes_pls_golite062009
trehalose-phosphatase activity 7.58500038184065 bayes_pls_golite062009
transferase activity, transferring hexosyl groups 3.70184884300914 bayes_pls_golite062009
catalytic activity 2.65148466065976 bayes_pls_golite062009
transferase activity, transferring glycosyl groups 2.62403914335522 bayes_pls_golite062009
transferase activity 2.18054407163329 bayes_pls_golite062009
UDP-glycosyltransferase activity 2.13085705769565 bayes_pls_golite062009
carbohydrate phosphatase activity 0.78952375993773 bayes_pls_golite062009
UDP-N-acetylglucosamine 2-epimerase activity 0.690032302126686 bayes_pls_golite062009
glycogen phosphorylase activity 0.607220464589157 bayes_pls_golite062009
binding 0.345236672370351 bayes_pls_golite062009
phosphorylase activity 0.296436712681472 bayes_pls_golite062009
mannosyltransferase activity 0.253888301381021 bayes_pls_golite062009
protein binding 0.198267161626932 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [814-1098]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NTKTLMEDYQ SSKKRMFVFN IAEPPSSRMI SILNDMTSKG NIVYIMNSFP KPILENLYSR  60
   61 VQNIGLIAEN GAYVSLNGVW YNIVDQVDWR NDVAKILEDK VERLPGSYYK INESMIKFHT 120
  121 ENAEDQDRVA SVIGDAITHI NTVFDHRGIH AYVYKNVVSV QQVGLSLSAA QFLFRFYNSA 180
  181 SDPLDTSSGQ ITNIQTPSQQ NPSDQEQQPP ASPTVSMNHI DFACVSGSSS PVLEPLFKLV 240
  241 NDEASEGQVK AGHAIVYGDA TSTYAKEHVN GLNELFTIIS RIIED

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.09691
Match: 1u02A
Description: Crystal structure of trehalose-6-phosphate phosphatase related protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
trehalose-phosphatase activity 3.78859922218487 bayes_pls_golite062009
transporter activity 2.28749015584769 bayes_pls_golite062009
hydrolase activity 2.23636068759523 bayes_pls_golite062009
transmembrane transporter activity 2.17051010073814 bayes_pls_golite062009
substrate-specific transporter activity 2.14633664297706 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.05684652641195 bayes_pls_golite062009
ion transmembrane transporter activity 2.05060633349756 bayes_pls_golite062009
cation transmembrane transporter activity 1.84740904871745 bayes_pls_golite062009
catalytic activity 1.55296860681783 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions 1.53201151596704 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 1.45647470429539 bayes_pls_golite062009
ATPase activity, coupled 1.44542004757594 bayes_pls_golite062009
nucleoside-triphosphatase activity 1.42792997211574 bayes_pls_golite062009
ATPase activity 1.40341876769691 bayes_pls_golite062009
pyrophosphatase activity 1.352553895791 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism 1.33388154652051 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 1.33292469269496 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1.33065047107664 bayes_pls_golite062009
metal ion transmembrane transporter activity 1.31602086166435 bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity 0.28050944646617 bayes_pls_golite062009
active transmembrane transporter activity 0.194344891491143 bayes_pls_golite062009
phosphatase activity 0.159899259988948 bayes_pls_golite062009
cation-transporting ATPase activity 0.15490458026932 bayes_pls_golite062009
phosphoric ester hydrolase activity 0.103902756538853 bayes_pls_golite062009
primary active transmembrane transporter activity 0.053543166906854 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 0.041293091790546 bayes_pls_golite062009
binding 0.0209333912048011 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle