YRC Public Data Repository - Protein Structure Prediction

Protein:	CAR2
Organism:	Saccharomyces cerevisiae
Length:	424 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CAR2.

Description	E-value	Query Range	Subject Range
OAT_YEAST - Ornithine aminotransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CAR2 PE=1 SV=... CAR2 - L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is d... gi\|151940953 - gi\|151940953\|gb\|EDN59335.1\| ornithine aminotransferase [Saccharomyces cerevisiae YJM789]	0.0	[1..424]	[1..424]
ARGD_METJA - Acetylornithine aminotransferase OS=Methanocaldococcus jannaschii GN=argD PE=3 SV=1 ARGD_METJA - Acetylornithine aminotransferase OS=Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JA...	0.0	[6..424]	[1..396]
OAT_ARATH - Ornithine aminotransferase, mitochondrial OS=Arabidopsis thaliana GN=DELTA-OAT PE=1 SV=1	0.0	[4..422]	[36..444]
OAT_MOUSE - Ornithine aminotransferase, mitochondrial OS=Mus musculus GN=Oat PE=1 SV=1	0.0	[2..421]	[33..436]
OAT_EMENI - Ornithine aminotransferase (EC 2.6.1.13) (Ornithine--oxo-acid aminotransferase) - Emericella nidulan...	0.0	[7..424]	[17..428]
OAT - ornithine aminotransferase gi\|114633242, gi... - gi\|114633244\|ref\|XP_001135280.1\| PREDICTED: hypothetical protein isoform 4 [Pan troglodytes], gi\|114...	0.0	[6..421]	[38..436]
gi\|87128021\|gb\|A... - Ornithine aminotransferase [Staphylococcus aureus subsp. aureus USA300], Ornithine aminotransferase ... gi\|156979283, gi... - gi\|156979283\|ref\|YP_001441542.1\| ornithine--oxo-acid transaminase [Staphylococcus aureus subsp. aure... gi\|150373839, gi... - gi\|151221039\|ref\|YP_001331861.1\| ornithine--oxo-acid transaminase [Staphylococcus aureus subsp. aure... gi\|269202572\|ref... - ornithine--oxo-acid transaminase [Staphylococcus aureus subsp. aureus ED98] gi\|253316803 - gi\|253316803\|ref\|ZP_04840016.1\| ornithine--oxo-acid transaminase [Staphylococcus aureus subsp. aureu... gi\|255005747 - gi\|255005747\|ref\|ZP_05144348.2\| ornithine--oxo-acid transaminase [Staphylococcus aureus subsp. aureu... gi\|25287255 - pir\|\|F89862 ornithine aminotransferase [imported] - Staphylococcus aureus (strain N315) OAT2_STAAS - Ornithine aminotransferase 2 OS=Staphylococcus aureus (strain MSSA476) GN=rocD2 PE=3 SV=1 OAT2_STAAC - Ornithine aminotransferase 2 OS=Staphylococcus aureus (strain COL) GN=rocD2 PE=3 SV=1 OAT2_STAAW - Ornithine aminotransferase 2 OS=Staphylococcus aureus (strain MW2) GN=rocD2 PE=3 SV=1 gi\|160367966, gi... - gi\|161509157\|ref\|YP_001574816.1\| ornithine--oxo-acid transaminase [Staphylococcus aureus subsp. aure... gi\|88194651, gi\|... - gi\|88194651\|ref\|YP_499447.1\| ornithine--oxo-acid transaminase [Staphylococcus aureus subsp. aureus N... OAT2_STAAN - Ornithine aminotransferase 2 OS=Staphylococcus aureus (strain N315) GN=rocD2 PE=1 SV=1 gi\|221139391 - gi\|221139391\|ref\|ZP_03564190.1\| ornithine--oxo-acid transaminase [Staphylococcus aureus subsp. aureu... OAT2_STAAM - Ornithine aminotransferase 2 OS=Staphylococcus aureus (strain Mu50 / ATCC 700699) GN=rocD2 PE=3 SV=1 gi\|87162047, gi\|... - gi\|87162047\|ref\|YP_493560.1\| ornithine--oxo-acid transaminase [Staphylococcus aureus subsp. aureus U... gi\|221140421 - gi\|221140421\|ref\|ZP_03564914.1\| ornithine--oxo-acid transaminase [Staphylococcus aureus subsp. aureu...	0.0	[7..422]	[3..396]

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Predicted Domain #1

Region A:
Residues: [1-424]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEATLSSKQ TIEWENKYSA HNYHPLPVVF HKAKGAHVWD PEGKLYLDFL SAYSAVNQGH  60
   61 CHPHIIKALT EQAQTLTLSS RAFHNDVYAQ FAKFVTEFFG FETVLPMNTG AEAVETALKL 120
  121 ARRWGYMKKN IPQDKAIILG AEGNFHGRTF GAISLSTDYE DSKLHFGPFV PNVASGHSVH 180
  181 KIRYGHAEDF VPILESPEGK NVAAIILEPI QGEAGIVVPP ADYFPKVSAL CRKHNVLLIV 240
  241 DEIQTGIGRT GELLCYDHYK AEAKPDIVLL GKALSGGVLP VSCVLSSHDI MSCFTPGSHG 300
  301 STFGGNPLAS RVAIAALEVI RDEKLCQRAA QLGSSFIAQL KALQAKSNGI ISEVRGMGLL 360
  361 TAIVIDPSKA NGKTAWDLCL LMKDHGLLAK PTHDHIIRLA PPLVISEEDL QTGVETIAKC 420
  421 IDLL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1289.0
Match:	2canA_
Description:	Ornithine aminotransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
4-aminobutyrate transaminase activity	3.63797881096751	bayes_pls_golite062009
L-aspartate:2-oxoglutarate aminotransferase activity	3.359406422625	bayes_pls_golite062009
transferase activity	2.59075614411581	bayes_pls_golite062009
catalytic activity	2.29878871754893	bayes_pls_golite062009
5-aminolevulinate synthase activity	1.85905571238884	bayes_pls_golite062009
adenosylmethionine-8-amino-7-oxononanoate transaminase activity	1.74778109525713	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor	1.63055151623667	bayes_pls_golite062009
glycine dehydrogenase (decarboxylating) activity	1.63055151623667	bayes_pls_golite062009
N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity	1.4383564662931	bayes_pls_golite062009
glutamate decarboxylase activity	1.34215658716536	bayes_pls_golite062009
transferase activity, transferring nitrogenous groups	1.28316822767388	bayes_pls_golite062009
transaminase activity	1.24990480711889	bayes_pls_golite062009
transferase activity, transferring acyl groups	1.19150094103499	bayes_pls_golite062009
transcription regulator activity	0.977210827616757	bayes_pls_golite062009
nucleic acid binding	0.892872530648552	bayes_pls_golite062009
ligase activity	0.827063849687833	bayes_pls_golite062009
DNA binding	0.803965264969424	bayes_pls_golite062009
succinate-semialdehyde dehydrogenase binding	0.78144409237642	bayes_pls_golite062009
carbon-sulfur lyase activity	0.698312655247044	bayes_pls_golite062009
intramolecular transferase activity, transferring amino groups	0.659071155545801	bayes_pls_golite062009
transcription factor activity	0.597417107954964	bayes_pls_golite062009
N-succinyltransferase activity	0.52897097514616	bayes_pls_golite062009
binding	0.49769115245722	bayes_pls_golite062009
ornithine-oxo-acid transaminase activity	0.311107335626334	bayes_pls_golite062009
N-acyltransferase activity	0.2609065149092	bayes_pls_golite062009
kynureninase activity	0.242752584041108	bayes_pls_golite062009
pyridoxal phosphate binding	0.16957228630576	bayes_pls_golite062009
vitamin B6 binding	0.16957228630576	bayes_pls_golite062009
cystathionine beta-lyase activity	0.15938456446406	bayes_pls_golite062009
methyltransferase activity	0.103986924428507	bayes_pls_golite062009
sulfurtransferase activity	0.0450490929307473	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	0.0254276656964899	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: