YRC Public Data Repository - Protein Structure Prediction

Protein:	XPT1
Organism:	Saccharomyces cerevisiae
Length:	209 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for XPT1.

Description	E-value	Query Range	Subject Range
gi\|151945197 - gi\|151945197\|gb\|EDN63448.1\| xanthine phosphoribosyl transferase [Saccharomyces cerevisiae YJM789] gi\|190409603 - gi\|190409603\|gb\|EDV12868.1\| xanthine phosphoribosyltransferase 1 [Saccharomyces cerevisiae RM11-1a] XPT1 - Xanthine-guanine phosphoribosyl transferase, required for xanthine utilization and for optimal utili... XPT1_YEAST - Xanthine phosphoribosyltransferase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=XPT...	2.0E-39	[1..209]	[1..209]
TILS_LISIN - Bifunctional protein TilS/HprT OS=Listeria innocua serovar 6a (strain CLIP 11262) GN=tilS/hprT PE=3 ... TILS_LISIN - Bifunctional protein tilS/hprT OS=Listeria innocua GN=tilS/hprT PE=3 SV=1	1.0E-34	[2..207]	[472..639]
gi\|224500330 - gi\|224500330\|ref\|ZP_03668679.1\| hypothetical protein LmonF1_11939 [Listeria monocytogenes Finland 19... gi\|224503461 - gi\|224503461\|ref\|ZP_03671768.1\| hypothetical protein LmonFR_13287 [Listeria monocytogenes FSL R2-561... gi\|126941298, gi... - gi\|254900996\|ref\|ZP_05260920.1\| hypothetical protein LmonJ_14318 [Listeria monocytogenes J0161], gi\|... gi\|254913936, gi... - gi\|254913936\|ref\|ZP_05263948.1\| hypothetical protein LmonJ2_14108 [Listeria monocytogenes J2818], gi... gi\|133733948, gi... - gi\|254938274\|ref\|ZP_05269971.1\| hypothetical protein LmonF6_14141 [Listeria monocytogenes F6900], gi... gi\|47014358, gi\|... - gi\|47097258\|ref\|ZP_00234818.1\| conserved hypothetical protein/hypoxanthine phosphoribosyltransferase... TILS_LISMO - Bifunctional protein TilS/HprT OS=Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) ... TILS_LISMO - Bifunctional protein tilS/hprT OS=Listeria monocytogenes GN=tilS/hprT PE=3 SV=1	2.0E-34	[2..207]	[472..639]
gi\|229512851, gi... - gi\|229512851\|ref\|ZP_04402318.1\| hypoxanthine-guanine phosphoribosyltransferase [Vibrio cholerae TMA ... gi\|229344301, gi... - gi\|229519612\|ref\|ZP_04409055.1\| hypoxanthine-guanine phosphoribosyltransferase [Vibrio cholerae RC9]... gi\|229520878, gi... - gi\|229520878\|ref\|ZP_04410300.1\| hypoxanthine-guanine phosphoribosyltransferase [Vibrio cholerae TM 1... gi\|229338823, gi... - gi\|229525242\|ref\|ZP_04414647.1\| hypoxanthine-guanine phosphoribosyltransferase [Vibrio cholerae bv. ... gi\|254850820, gi... - gi\|75828944\|ref\|ZP_00758271.1\| COG0634: Hypoxanthine-guanine phosphoribosyltransferase [Vibrio chole... gi\|229332168, gi... - gi\|229530395\|ref\|ZP_04419783.1\| hypoxanthine-guanine phosphoribosyltransferase [Vibrio cholerae 1212... gi\|146316431, gi... - gi\|75825952\|ref\|ZP_00755387.1\| COG0634: Hypoxanthine-guanine phosphoribosyltransferase [Vibrio chole... gi\|229368784, gi... - gi\|229606129\|ref\|YP_002876777.1\| hypoxanthine-guanine phosphoribosyltransferase [Vibrio cholerae MJ-... gi\|116218878, gi... - gi\|75818065\|ref\|ZP_00748289.1\| COG0634: Hypoxanthine-guanine phosphoribosyltransferase [Vibrio chole... gi\|121730073, gi... - gi\|75814377\|ref\|ZP_00744974.1\| COG0634: Hypoxanthine-guanine phosphoribosyltransferase [Vibrio chole... gi\|197751413, gi... - gi\|254291274\|ref\|ZP_04962069.1\| hypoxanthine phosphoribosyltransferase [Vibrio cholerae AM-19226], g... gi\|153830221, gi... - gi\|153830221\|ref\|ZP_01982888.1\| hypoxanthine phosphoribosyltransferase [Vibrio cholerae 623-39], gi\|... gi\|9655015, gi\|1... - gi\|9655015\|gb\|AAF93752.1\| hypoxanthine phosphoribosyltransferase [Vibrio cholerae O1 biovar El Tor s... gi\|121547101, gi... - gi\|121591030\|ref\|ZP_01678346.1\| hypoxanthine phosphoribosyltransferase [Vibrio cholerae 2740-80], gi... gi\|149738693, gi... - gi\|153827390\|ref\|ZP_01980057.1\| hypoxanthine phosphoribosyltransferase [Vibrio cholerae MZO-2], gi\|1... gi\|11258290 - pir\|\|E82306 hypoxanthine phosphoribosyltransferase VC0585 [imported] - Vibrio cholerae (strain N1696... gi\|153224139, gi... - gi\|153224139\|ref\|ZP_01954244.1\| hypoxanthine phosphoribosyltransferase [Vibrio cholerae MAK 757], gi... gi\|124121292, gi... - gi\|153803189\|ref\|ZP_01957775.1\| hypoxanthine phosphoribosyltransferase [Vibrio cholerae MZO-3], gi\|1... gi\|126509292, gi... - gi\|153820163\|ref\|ZP_01972830.1\| hypoxanthine phosphoribosyltransferase [Vibrio cholerae NCTC 8457], ... gi\|229509178, gi... - gi\|229509178\|ref\|ZP_04398663.1\| hypoxanthine-guanine phosphoribosyltransferase [Vibrio cholerae B33]... gi\|227080768, gi... - gi\|227080768\|ref\|YP_002809319.1\| hypoxanthine phosphoribosyltransferase [Vibrio cholerae M66-2], gi\|... gi\|229507193, gi... - gi\|229507193\|ref\|ZP_04396699.1\| hypoxanthine-guanine phosphoribosyltransferase [Vibrio cholerae BX 3...	2.0E-33	[1..207]	[1..170]
gi\|116077257, gi... - gi\|116516681\|ref\|YP_815435.1\| hypoxanthine-guanine phosphoribosyltransferase [Streptococcus pneumoni... gi\|225853623, gi... - gi\|225853623\|ref\|YP_002735135.1\| hypoxanthine phosphoribosyltransferase [Streptococcus pneumoniae JJ... gi\|221230960, gi... - gi\|221230960\|ref\|YP_002510112.1\| hypoxanthine-guanine phosphoribosyltransferase [Streptococcus pneum... HPRT_STRR6 - Hypoxanthine-guanine phosphoribosyltransferase OS=Streptococcus pneumoniae (strain ATCC BAA-255 / R6... HPRT_STRPN - Hypoxanthine-guanine phosphoribosyltransferase OS=Streptococcus pneumoniae GN=hpt PE=3 SV=1 HPRT_STRPN - Hypoxanthine-guanine phosphoribosyltransferase OS=Streptococcus pneumoniae serotype 4 (strain ATCC B... gi\|147762895, gi... - gi\|149013372\|ref\|ZP_01834081.1\| hypoxanthine phosphoribosyltransferase [Streptococcus pneumoniae SP1... gi\|148993573, gi... - gi\|148993573\|ref\|ZP_01823044.1\| hypoxanthine phosphoribosyltransferase [Streptococcus pneumoniae SP9... gi\|148988916, gi... - gi\|148988916\|ref\|ZP_01820331.1\| hypoxanthine phosphoribosyltransferase [Streptococcus pneumoniae SP6... gi\|168484296, gi... - gi\|172042419\|gb\|EDT50465.1\| hypoxanthine phosphoribosyltransferase [Streptococcus pneumoniae CDC1873... gi\|147923333, gi... - gi\|148984556\|ref\|ZP_01817844.1\| hypoxanthine phosphoribosyltransferase [Streptococcus pneumoniae SP3... gi\|168493988, gi... - gi\|183575891\|gb\|EDT96419.1\| hypoxanthine phosphoribosyltransferase [Streptococcus pneumoniae CDC3059... gi\|168489347, gi... - gi\|183572298\|gb\|EDT92826.1\| hypoxanthine phosphoribosyltransferase [Streptococcus pneumoniae SP195],... gi\|194397408, gi... - gi\|194397408\|ref\|YP_002036733.1\| hypoxanthine-guanine phosphoribosyltransferase [Streptococcus pneum... gi\|182628315, gi... - gi\|182682981\|ref\|YP_001834728.1\| hypoxanthine-guanine phosphoribosyltransferase [Streptococcus pneum...	3.0E-33	[2..207]	[4..171]
gi\|309315, gi\|73... - gi\|7305155\|ref\|NP_038584.1\| hypoxanthine guanine phosphoribosyl transferase 1 [Mus musculus], gi\|309...	3.0E-32	[2..203]	[30..202]
gi\|28899289, gi\|... - gi\|28899289\|ref\|NP_798894.1\| hypoxanthine-guanine phosphoribosyltransferase [Vibrio parahaemolyticus... gi\|28807513, gi\|... - gi\|28807513\|dbj\|BAC60778.1\| hypoxanthine ribosyl transferase [Vibrio parahaemolyticus RIMD 2210633],...	3.0E-32	[1..207]	[1..170]
HPRT_RAT - Hypoxanthine-guanine phosphoribosyltransferase OS=Rattus norvegicus GN=Hprt1 PE=1 SV=1 gi\|244376, gi\|21... - gi\|244376\|gb\|AAB21288.1\| hypoxanthine phosphoribosyltransferase; HPRT [Rattus sp.], gi\|2117729\|pir\|\|...	4.0E-32	[2..203]	[30..202]
gi\|153997549, gi... - gi\|153997549\|ref\|ZP_02022649.1\| hypoxanthine phosphoribosyltransferase [Yersinia pestis CA88-4125], ... gi\|25286886 - pir\|\|AB0414 hypoxanthine phosphoribosyltransferase (EC 2.4.2.8) [imported] - Yersinia pestis (strain... gi\|229695413, gi... - gi\|229839047\|ref\|ZP_04459206.1\| hypoxanthine phosphoribosyltransferase [Yersinia pestis biovar Orien... gi\|229687104, gi... - gi\|229899612\|ref\|ZP_04514753.1\| hypoxanthine phosphoribosyltransferase [Yersinia pestis biovar Orien... gi\|115349036, gi... - gi\|218930425\|ref\|YP_002348300.1\| hypoxanthine phosphoribosyltransferase [Yersinia pestis CO92], gi\|1...	5.0E-32	[1..207]	[1..171]
HPRT_CHICK - Hypoxanthine-guanine phosphoribosyltransferase OS=Gallus gallus GN=HPRT1 PE=2 SV=1	7.0E-32	[3..206]	[31..205]

Back

Predicted Domain #1

Region A:
Residues: [1-209]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAENERMYIS YNNIHKLCQG VAKHILARNE RPDIIIAITG GGMIPARIIR SFLKTKGQKN  60
   61 IPIQAIGLSL YEDLGLDNSV ETIGKEVIRT QWLDFGALNQ HFDSLIGKKV LIVDEVDDTR 120
  121 TTLHYAVSEL EKEIAEQQKV LNRMSEETVI SIFVLHNKDK PKRAGLPDSM MNSGRYIAAQ 180
  181 TVPDKWLCYP WDAEDIEEHT MLAKAQGHD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	32.39794
Match:	1bzyA_
Description:	Hypoxantine-guanine PRTase (HGPRTase)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transferase activity, transferring glycosyl groups	3.91023158228049	bayes_pls_golite062009
hypoxanthine phosphoribosyltransferase activity	3.89356447922614	bayes_pls_golite062009
adenine phosphoribosyltransferase activity	3.83339863213875	bayes_pls_golite062009
transferase activity, transferring pentosyl groups	2.53679639481311	bayes_pls_golite062009
uracil phosphoribosyltransferase activity	2.36237864658341	bayes_pls_golite062009
catalytic activity	2.30431811394775	bayes_pls_golite062009
transferase activity	2.03376808731027	bayes_pls_golite062009
amidophosphoribosyltransferase activity	1.51802880667162	bayes_pls_golite062009
ribose phosphate diphosphokinase activity	1.18255665419929	bayes_pls_golite062009
diphosphotransferase activity	0.749909396904601	bayes_pls_golite062009
purine binding	0.745430157183377	bayes_pls_golite062009
nucleic acid binding	0.552133387792911	bayes_pls_golite062009
binding	0.535390228935555	bayes_pls_golite062009
DNA binding	0.439741935655503	bayes_pls_golite062009
transcription regulator activity	0.396538943915776	bayes_pls_golite062009
orotate phosphoribosyltransferase activity	0.148898393751978	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: