YRC Public Data Repository - Protein Structure Prediction

Protein:	MET3
Organism:	Saccharomyces cerevisiae
Length:	511 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MET3.

Description	E-value	Query Range	Subject Range
MET3 - ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assim... gi\|190409497 - gi\|190409497\|gb\|EDV12762.1\| ATP sulfurylase [Saccharomyces cerevisiae RM11-1a] MET3_YEAST - Sulfate adenylyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MET3 PE=1 SV... gi\|151945086 - gi\|151945086\|gb\|EDN63337.1\| ATP sulfurylase [Saccharomyces cerevisiae YJM789]	0.0	[1..511]	[1..511]
gi\|15865513 - gi\|15865513\|emb\|CAC82078.1\| ATP sulphurylase [Aspergillus fumigatus]	0.0	[3..509]	[4..571]
MET3_CANAL - Sulfate adenylyltransferase (EC 2.7.7.4) (Sulfate adenylate transferase) (SAT) (ATP-sulfurylase) - C...	0.0	[1..509]	[3..527]
gi\|211588029 - gi\|211588029\|emb\|CAP86100.1\| sulfate adenylyltransferase aps-Penicillium chrysogenum [Penicillium ch... gi\|15826363, gi\|... - gi\|15826364\|pdb\|1I2D\|C Chain C, Crystal Structure Of Atp Sulfurylase From Penicillium Chrysogenum, g...	0.0	[3..508]	[4..569]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[3..508]	[4..569]
MET3_EMENI - Sulfate adenylyltransferase OS=Emericella nidulans GN=met3 PE=3 SV=1 MET3_EMENI - Sulfate adenylyltransferase OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL ...	0.0	[3..509]	[4..571]

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Predicted Domain #1

Region A:
Residues: [1-166]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPAPHGGILQ DLIARDALKK NELLSEAQSS DILVWNLTPR QLCDIELILN GGFSPLTGFL  60
   61 NENDYSSVVT DSRLADGTLW TIPITLDVDE AFANQIKPDT RIALFQDDEI PIAILTVQDV 120
  121 YKPNKTIEAE KVFRGDPEHP AISYLFNVAG DYYVGGSLEA IQLPQH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	11000.0
Match:	1g8fA_
Description:	ATP sulfurylase N-terminal domain; ATP sulfurylase central domain; ATP sulfurylase C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ligase activity, forming aminoacyl-tRNA and related compounds	3.92128383038213	bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds	3.92128383038213	bayes_pls_golite062009
aminoacyl-tRNA ligase activity	3.90993291504728	bayes_pls_golite062009
binding	1.78987673253351	bayes_pls_golite062009
glutamate-tRNA ligase activity	1.10341596187455	bayes_pls_golite062009
methionine-tRNA ligase activity	1.04188732284751	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
nucleic acid binding	0.831762535895849	bayes_pls_golite062009
purine nucleotide binding	0.428373955572763	bayes_pls_golite062009
purine ribonucleotide binding	0.424644011903671	bayes_pls_golite062009
ribonucleotide binding	0.424583288440993	bayes_pls_golite062009
nucleotide binding	0.422354428195324	bayes_pls_golite062009
tyrosine-tRNA ligase activity	0.366166475448387	bayes_pls_golite062009
adenylyltransferase activity	0.19674866587635	bayes_pls_golite062009
DNA binding	0.143403729737365	bayes_pls_golite062009
sulfate adenylyltransferase activity	0.131596240193754	bayes_pls_golite062009
sulfate adenylyltransferase (ATP) activity	0.118324944285084	bayes_pls_golite062009
nucleotidyltransferase activity	0.0927746101202402	bayes_pls_golite062009
ATP binding	0.04834397972685	bayes_pls_golite062009
adenyl ribonucleotide binding	0.0149501427627318	bayes_pls_golite062009
transcription regulator activity	0.0147430141176288	bayes_pls_golite062009
adenyl nucleotide binding	0.00365326483311895	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [167-330]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YDYPGLRKTP AQLRLEFQSR QWDRVVAFQT RNPMHRAHRE LTVRAAREAN AKVLIHPVVG  60
   61 LTKPGDIDHH TRVRVYQEII KRYPNGIAFL SLLPLAMRMS GDREAVWHAI IRKNYGASHF 120
  121 IVGRDHAGPG KNSKGVDFYG PYDAQELVES YKHELDIEVV PFRM

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	11000.0
Match:	1g8fA_
Description:	ATP sulfurylase N-terminal domain; ATP sulfurylase central domain; ATP sulfurylase C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [331-389]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VTYLPDEDRY APIDQIDTTK TRTLNISGTE LRRRLRVGGE IPEWFSYPEV VKILRESNP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	11000.0
Match:	1g8fA_
Description:	ATP sulfurylase N-terminal domain; ATP sulfurylase central domain; ATP sulfurylase C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [390-511]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PRPKQGFSIV LGNSLTVSRE QLSIALLSTF LQFGGGRYYK IFEHNNKTEL LSLIQDFIGS  60
   61 GSGLIIPNQW EDDKDSVVGK QNVYLLDTSS SADIQLESAD EPISHIVQKV VLFLEDNGFF 120
  121 VF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	11000.0
Match:	1g8fA_
Description:	ATP sulfurylase N-terminal domain; ATP sulfurylase central domain; ATP sulfurylase C-terminal domain
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: