YRC Public Data Repository - Protein Structure Prediction

Protein:	SPT10
Organism:	Saccharomyces cerevisiae
Length:	640 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPT10.

Description	E-value	Query Range	Subject Range
SPT10 - Putative histone acetylase, sequence-specific activator of histone genes, binds specifically and hig... SPT10_YEAST - Protein SPT10 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SPT10 PE=1 SV=1	0.0	[1..640]	[1..640]
gi\|17988346, gi\|... - gi\|17988346\|ref\|NP_540979.1\| ribosomal-protein-serine acetyltransferase [Brucella melitensis 16M], g... gi\|25527000 - pir\|\|AH3509 ribosomal-protein-serine acetyltransferase (EC 2.3.1.-) [imported] - Brucella melitensis...	2.0E-36	[66..301]	[4..242]
AZET_SCHPO - L-azetidine-2-carboxylic acid acetyltransferase OS=Schizosaccharomyces pombe (strain 972 / ATCC 2484... ppr1 - L-azetidine-2-carboxylic acid acetyltransferase	2.0E-32	[70..277]	[34..209]
gi\|15831306, gi\|... - gi\|15831306\|ref\|NP_310079.1\| putative resistance protein [Escherichia coli O157:H7 str. Sakai], gi\|1... gi\|110343220, gi... - gi\|110641628\|ref\|YP_669358.1\| acetyltransferase YncA [Escherichia coli 536], gi\|110343220\|gb\|ABG6945... gi\|81241135, gi\|... - gi\|82776987\|ref\|YP_403336.1\| putative resistance protein [Shigella dysenteriae Sd197], gi\|81241135\|g... gi\|209911981, gi... - gi\|209918722\|ref\|YP_002292806.1\| putative acetyltransferase [Escherichia coli SE11], gi\|209911981\|db... gi\|115512814, gi... - gi\|117623690\|ref\|YP_852603.1\| acyltransferase [Escherichia coli APEC O1], gi\|115512814\|gb\|ABJ00889.1... gi\|195936939 - gi\|195936939\|ref\|ZP_03082321.1\| acyltransferase [Escherichia coli O157:H7 str. EC4024] gi\|218365147, gi... - gi\|218558378\|ref\|YP_002391291.1\| putative acyltransferase with acyl-CoA N-acyltransferase domain [Es... gi\|215486684, gi... - gi\|215486684\|ref\|YP_002329115.1\| predicted acyltransferase with acyl-CoA N-acyltransferase domain [E... gi\|218704917, gi... - gi\|218704917\|ref\|YP_002412436.1\| putative acyltransferase with acyl-CoA N-acyltransferase domain [Es... gi\|218689376, gi... - gi\|218689376\|ref\|YP_002397588.1\| putative acyltransferase with acyl-CoA N-acyltransferase domain [Es... gi\|25286354, gi\|... - pir\|\|C85733 probable resistance protein Z2271 [imported] - Escherichia coli (strain O157:H7, substra... gi\|15801695, gi\|... - gi\|15801695\|ref\|NP_287713.1\| putative resistance protein [Escherichia coli O157:H7 EDL933], gi\|12515... gi\|254592393, gi... - gi\|254792993\|ref\|YP_003077830.1\| predicted acyltransferase with acyl-CoA N-acyltransferase domain [E... gi\|15831306, gi\|... - gi\|15831306\|ref\|NP_310079.1\| putative resistance protein [Escherichia coli O157:H7], gi\|13361518\|dbj... gi\|83570845 - gi\|83570845\|ref\|ZP_00922287.1\| COG1247: Sortase and related acyltransferases [Shigella dysenteriae 1... gi\|75190496 - gi\|75190496\|ref\|ZP_00703763.1\| COG1247: Sortase and related acyltransferases [Escherichia coli E2437... gi\|75240199 - gi\|75240199\|ref\|ZP_00724151.1\| COG1247: Sortase and related acyltransferases [Escherichia coli F11]	3.0E-30	[107..275]	[12..168]
gi\|15900190, gi\|... - gi\|66877108\|ref\|ZP_00402752.1\| COG1670: Acetyltransferases, including N-acetylases of ribosomal prot... gi\|25388270 - pir\|\|A95030 acetyltransferase, GNAT family [imported] - Streptococcus pneumoniae (strain TIGR4)	4.0E-30	[86..293]	[23..226]
EG13770 - methionine N-acyltransferase; L-amino acid N-acyltransferase / Methionine N-acyltransferase; L-amino... EG13770 - methionine N-acyltransferase; L-amino acid N-acyltransferase / Methionine N-acyltransferase; L-amino... gi\|169888957, gi... - gi\|170081122\|ref\|YP_001730442.1\| acyltransferase [Escherichia coli str. K-12 substr. DH10B], gi\|1698... YNCA_ECOLI - Hypothetical acetyltransferase yncA (EC 2.3.1.-) - Escherichia coli gi\|238900675, gi... - gi\|238900675\|ref\|YP_002926471.1\| putative acyltransferase with acyl-CoA N-acyltransferase domain [Es... gi\|89108291, gi\|... - gi\|89108291\|ref\|AP_002071.1\| predicted acyltransferase with acyl-CoA N-acyltransferase domain [Esche...	4.0E-30	[107..275]	[12..168]
gi\|1742360, gi\|1... - dbj\|BAA15083.1\| Phosphinothricin acetyltransferase (EC 2.3.1.-). [Escherichia coli], dbj\|BAA15080.1...	4.0E-30	[107..275]	[52..208]
gi\|189002446, gi... - gi\|189002446\|gb\|EDU71432.1\| acetyltransferase, GNAT family [Escherichia coli O157:H7 str. EC4076], g... gi\|189374447, gi... - gi\|189374447\|gb\|EDU92863.1\| acetyltransferase, GNAT family [Escherichia coli O157:H7 str. EC869], gi... gi\|15833544, gi\|... - gi\|15833544\|ref\|NP_312317.1\| hypothetical protein ECs4290 [Escherichia coli O157:H7], gi\|13363764\|db... gi\|195934935 - gi\|195934935\|ref\|ZP_03080317.1\| putative acetyltransferase YhhY [Escherichia coli O157:H7 str. EC402... gi\|208727519, gi... - gi\|208807718\|ref\|ZP_03250055.1\| acetyltransferase, GNAT family [Escherichia coli O157:H7 str. EC4206... gi\|168747067, gi... - gi\|188018257\|gb\|EDU56379.1\| acetyltransferase, GNAT family [Escherichia coli O157:H7 str. EC4113], g... gi\|189369693, gi... - gi\|189369693\|gb\|EDU88109.1\| acetyltransferase, GNAT family [Escherichia coli O157:H7 str. EC4501], g... gi\|168772652, gi... - gi\|187771356\|gb\|EDU35200.1\| acetyltransferase, GNAT family [Escherichia coli O157:H7 str. EC4196], g... gi\|209756190, gi... - pir\|\|B91165 hypothetical protein ECs4290 [imported] - Escherichia coli (strain O157:H7, substrain R... gi\|15833544, gi\|... - gi\|15833544\|ref\|NP_312317.1\| putative acetyltransferase YhhY [Escherichia coli O157:H7 str. Sakai], ... gi\|254795360, gi... - gi\|254795360\|ref\|YP_003080197.1\| predicted acetyltransferase [Escherichia coli O157:H7 str. TW14359]... gi\|209399576, gi... - gi\|209399576\|ref\|YP_002272883.1\| acetyltransferase, GNAT family [Escherichia coli O157:H7 str. EC411... gi\|217321952, gi... - gi\|217325731\|ref\|ZP_03441815.1\| acetyltransferase, GNAT family [Escherichia coli O157:H7 str. TW1458...	5.0E-30	[109..267]	[4..160]

Back

Predicted Domain #1

Region A:
Residues: [1-88]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLNQHTSSVP DDEHLQMAHQ NSSSEVRNEA AVPDQLLTPL QPYTILLKDG ETIATMYPIP  60
   61 AYPDLLPLGL LNFLLDEFNM EVEKGDSF

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [89-309]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PYYETLSLEE FKNVWFHNDG HVCIMVLGEI PELDYSMDTE ADTNDNFGTE IETTKHTTQY  60
   61 KKRKERRNLN LSMQWEKQCL GIFDLKPAYP GRSAHVVTGT FLVNAGIRGK GIGKTLMETF 120
  121 IEWSKKLGFT SSFFPLIYGT NVGIRRILEG LNFRRIGKLP EAGILKGFDV PVDSFMYGKE 180
  181 FTHITKSIDL LRDPQKSIEI GKYERLKHFL ETGKYPLHCD R

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	7.221849
Match:	1b87A_
Description:	Aminoglycoside 6'-N-acetyltransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
N-acetyltransferase activity	4.32406263750499	bayes_pls_golite062009
N-acyltransferase activity	4.26078833573813	bayes_pls_golite062009
histone acetyltransferase activity	4.12956006910653	bayes_pls_golite062009
lysine N-acetyltransferase activity	4.12956006910653	bayes_pls_golite062009
acetyltransferase activity	3.10399129332319	bayes_pls_golite062009
transcription regulator activity	2.24760844790231	bayes_pls_golite062009
nucleic acid binding	2.13750665291344	bayes_pls_golite062009
catalytic activity	1.97933499002461	bayes_pls_golite062009
transferase activity	1.72447231774431	bayes_pls_golite062009
	1.69317676984704	bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups	1.47571666298157	bayes_pls_golite062009
acyltransferase activity	1.47230586550141	bayes_pls_golite062009
transferase activity, transferring acyl groups	1.42711272311757	bayes_pls_golite062009
transcription repressor activity	1.31507488567214	bayes_pls_golite062009
binding	1.22537494136129	bayes_pls_golite062009
transcription factor binding	1.13174003342838	bayes_pls_golite062009
transcription activator activity	0.891911076312861	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.605899196605446	bayes_pls_golite062009
histone binding	0.582104626133107	bayes_pls_golite062009
transcription cofactor activity	0.31196049232138	bayes_pls_golite062009
transcription coactivator activity	0.17675473564653	bayes_pls_golite062009
protein binding	0.075825416385311	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [310-397]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NEKARLRVLS KTHSVLNGKL MTKGKEIIYD TDQQIQIALE IHLMEHLGIN KVTSKIGEKY  60
   61 HWRGIKSTVS EVISRCQKCK MRYKDGTG

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	8.53
Match:	1k6yA
Description:	N-terminal Zn binding domain of HIV integrase; Retroviral integrase, catalytic domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
exonuclease activity	2.24517802933873	bayes_pls_golite062009
transcription regulator activity	2.22832306273638	bayes_pls_golite062009
nuclease activity	2.17049593048518	bayes_pls_golite062009
nucleic acid binding	2.15202443486046	bayes_pls_golite062009
DNA binding	1.88388568255929	bayes_pls_golite062009
ribonuclease activity	1.7264885813713	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	1.54823157746404	bayes_pls_golite062009
binding	1.42021256417703	bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	1.23245248968126	bayes_pls_golite062009
transcription factor activity	1.18792852183348	bayes_pls_golite062009
catalytic activity	1.16880796007849	bayes_pls_golite062009
deoxyribonuclease activity	0.819269466567015	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.618022514104206	bayes_pls_golite062009
endonuclease activity	0.591008475846166	bayes_pls_golite062009
DNA polymerase activity	0.470156503599777	bayes_pls_golite062009
3'-5' exonuclease activity	0.445309350267778	bayes_pls_golite062009
DNA-directed DNA polymerase activity	0.330636967059347	bayes_pls_golite062009
exoribonuclease activity	0.283617295697939	bayes_pls_golite062009
endoribonuclease activity, producing 5'-phosphomonoesters	0.244405458380391	bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters	0.211534069092691	bayes_pls_golite062009
endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	0.152950127352174	bayes_pls_golite062009
transcription activator activity	0.0924765766526223	bayes_pls_golite062009
protein binding	0.0799098348667361	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [398-640]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VIIEQKRAVK QAHMLPTQHI ETINNPRKSK KHDNALLGQA INFPQNIISS TLNDVEGEPT  60
   61 PPDTNIVQPT FQNATNSPAT TAEANEANKR SEFLSSIQST PLLDDEQSMN SFNRFVEEEN 120
  121 SRKRRKYLDV ASNGIVPHLT NNESQDHANP VNRDERDMNH SVPDLDRNDH TIMNDAMLSL 180
  181 EDNVMAALEM VQKEQQQKIN HRGEDVTGQQ IDLNNSEGNE NSVTKIVNNE SNTFTEHNSN 240
  241 IYY

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	8.53
Match:	1k6yA
Description:	N-terminal Zn binding domain of HIV integrase; Retroviral integrase, catalytic domain
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: