| Protein: | IRE1 |
| Organism: | Saccharomyces cerevisiae |
| Length: | 1115 amino acids |
| Reference: | Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for IRE1.
| Description | E-value | Query Range |
Subject Range |
|
|
0.0 | [1..1115] | [1..1115] |
|
|
0.0 | [48..1113] | [22..1070] |
|
|
0.0 | [564..1050] | [2..490] |
|
|
0.0 | [569..1048] | [20..491] |
|
|
0.0 | [501..1114] | [421..962] |
|
|
0.0 | [588..1076] | [39..521] |
|
|
0.0 | [564..1048] | [2..482] |
|
Region A: Residues: [1-471] |
1 11 21 31 41 51
| | | | | |
1 MRLLRRNMLV LTLLVCVFSS IISCSIPLSS RTSRRQIVED EVASTKKLNF NYGVDKNINS 60
61 PIPAPRTTEG LPNMKLSSYP TPNLLNTADN RRANKKGRRA ANSISVPYLE NRSLNELSLS 120
121 DILIAADVEG GLHAVDRRNG HIIWSIEPEN FQPLIEIQEP SRLETYETLI IEPFGDGNIY 180
181 YFNAHQGLQK LPLSIRQLVS TSPLHLKTNI VVNDSGKIVE DEKVYTGSMR TIMYTINMLN 240
241 GEIISAFGPG SKNGYFGSQS VDCSPEEKIK LQECENMIVI GKTIFELGIH SYDGASYNVT 300
301 YSTWQQNVLD VPLALQNTFS KDGMCIAPFR DKSLLASDLD FRIARWVSPT FPGIIVGLFD 360
361 VFNDLRTNEN ILVPHPFNPG DHESISSNKV YLDQTSNLSW FALSSQNFPS LVESAPISRY 420
421 ASSDRWRVSS IFEDETLFKN AIMGVHQIYN NEYDHLYENY EKTNSLDTTH K
|
| Detection Method: |  |
| Confidence: | 14.89 |
| Match: | 1h4iA |
| Description: | Methanol dehydrogenase, heavy chain |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [472-637] |
1 11 21 31 41 51
| | | | | |
1 YPPLMIDSSV DTTDLHQNNE MNSLKEYMSP EDLEAYRKKI HEQISRELDE KNQNSLLLKF 60
61 GSLVYRIIET GVFLLLFLIF CAILQRFKIL PPLYVLLSKI GFMPEKEIPI VESKSLNCPS 120
121 SSENVTKPFD MKSGKQVVFE GAVNDGSLKS EKDNDDADED DEKSLD
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [638-714] |
1 11 21 31 41 51
| | | | | |
1 LTTEKKKRKR GSRGGKKGRK SRIANIPNFE QSLKNLVVSE KILGYGSSGT VVFQGSFQGR 60
61 PVAVKRMLID FCDIALM
|
|
Region B: Residues: [732-747] |
1 11 21 31 41 51
| | | | | |
1 YCSETTDRFL YIALEL
|
| Detection Method: | |
| Confidence: | 253.38764 |
| Match: | 1gy3A_ |
| Description: | Cyclin-dependent PK, CDK2 |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [715-731] |
1 11 21 31 41 51
| | | | | |
1 EIKLLTESDD HPNVIRY
|
|
Region B: Residues: [748-1060] |
1 11 21 31 41 51
| | | | | |
1 CNLNLQDLVE SKNVSDENLK LQKEYNPISL LRQIASGVAH LHSLKIIHRD LKPQNILVST 60
61 SSRFTADQQT GAENLRILIS DFGLCKKLDS GQSSFRTNLN NPSGTSGWRA PELLEESNNL 120
121 QCQVETEHSS SRHTVVSSDS FYDPFTKRRL TRSIDIFSMG CVFYYILSKG KHPFGDKYSR 180
181 ESNIIRGIFS LDEMKCLHDR SLIAEATDLI SQMIDHDPLK RPTAMKVLRH PLFWPKSKKL 240
241 EFLLKVSDRL EIENRDPPSA LLMKFDAGSD FVIPSGDWTV KFDKTFMDNL ERYRKYHSSK 300
301 LMDLLRALRN KYH
|
| Detection Method: | |
| Confidence: | 253.38764 |
| Match: | 1gy3A_ |
| Description: | Cyclin-dependent PK, CDK2 |
| Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| phosphotransferase activity, alcohol group as acceptor | 5.49988294224815 | bayes_pls_golite062009 |
| protein kinase activity | 5.4586557943719 | bayes_pls_golite062009 |
| kinase activity | 5.3287080791198 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 4.96052051118534 | bayes_pls_golite062009 |
| cyclin-dependent protein kinase activity | 4.62392503670521 | bayes_pls_golite062009 |
| protein serine/threonine kinase activity | 4.46381887831481 | bayes_pls_golite062009 |
| transferase activity | 3.97138602499442 | bayes_pls_golite062009 |
| general RNA polymerase II transcription factor activity | 3.06466701648326 | bayes_pls_golite062009 |
| binding | 2.74863538127007 | bayes_pls_golite062009 |
| phosphoinositide 3-kinase binding | 2.41610417530517 | bayes_pls_golite062009 |
| protein binding | 2.276111749106 | bayes_pls_golite062009 |
| ATP binding | 1.97600611746091 | bayes_pls_golite062009 |
| adenyl ribonucleotide binding | 1.93596671856664 | bayes_pls_golite062009 |
| cation transmembrane transporter activity | 1.93176092222748 | bayes_pls_golite062009 |
| adenyl nucleotide binding | 1.90928021591891 | bayes_pls_golite062009 |
| ion transmembrane transporter activity | 1.90354666768303 | bayes_pls_golite062009 |
| molecular transducer activity | 1.79921740914853 | bayes_pls_golite062009 |
| signal transducer activity | 1.79921740914853 | bayes_pls_golite062009 |
| substrate-specific transmembrane transporter activity | 1.71452519680794 | bayes_pls_golite062009 |
| purine ribonucleotide binding | 1.65732943334212 | bayes_pls_golite062009 |
| ribonucleotide binding | 1.65726906484847 | bayes_pls_golite062009 |
| purine nucleotide binding | 1.63763394711025 | bayes_pls_golite062009 |
| nucleotide binding | 1.63195828048121 | bayes_pls_golite062009 |
| insulin receptor substrate binding | 1.62657794525303 | bayes_pls_golite062009 |
| transcription regulator activity | 1.56748951434625 | bayes_pls_golite062009 |
| nucleic acid binding | 1.46547714006072 | bayes_pls_golite062009 |
| MAP kinase kinase activity | 1.42275431028856 | bayes_pls_golite062009 |
| protein tyrosine kinase activity | 1.3898059094397 | bayes_pls_golite062009 |
| receptor signaling protein serine/threonine kinase activity | 1.38496328649031 | bayes_pls_golite062009 |
| DNA binding | 1.35333135345112 | bayes_pls_golite062009 |
| receptor signaling protein activity | 1.27291233344322 | bayes_pls_golite062009 |
| metal ion transmembrane transporter activity | 1.27184436658773 | bayes_pls_golite062009 |
| insulin receptor activity | 1.22442673174261 | bayes_pls_golite062009 |
| catalytic activity | 1.21655087018101 | bayes_pls_golite062009 |
| transcription factor activity | 1.10928254946881 | bayes_pls_golite062009 |
| fibroblast growth factor receptor activity | 1.01340572255694 | bayes_pls_golite062009 |
| transcription activator activity | 0.997272622653026 | bayes_pls_golite062009 |
| PTB domain binding | 0.9900774724568 | bayes_pls_golite062009 |
| insulin-like growth factor receptor binding | 0.872782211382796 | bayes_pls_golite062009 |
| MAP kinase activity | 0.81943579965027 | bayes_pls_golite062009 |
| insulin binding | 0.614254468447749 | bayes_pls_golite062009 |
| transporter activity | 0.595111702412257 | bayes_pls_golite062009 |
| cyclin-dependent protein kinase activating kinase activity | 0.529121666062889 | bayes_pls_golite062009 |
| protein serine/threonine/tyrosine kinase activity | 0.48345772948903 | bayes_pls_golite062009 |
| fibroblast growth factor binding | 0.470448662251808 | bayes_pls_golite062009 |
| protein kinase C activity | 0.41587987561486 | bayes_pls_golite062009 |
| transmembrane transporter activity | 0.41384976209545 | bayes_pls_golite062009 |
| RNA polymerase II transcription factor activity | 0.401250804041384 | bayes_pls_golite062009 |
| magnesium ion binding | 0.393328812780268 | bayes_pls_golite062009 |
| telethonin binding | 0.386946764759301 | bayes_pls_golite062009 |
| MAP kinase kinase kinase activity | 0.37115026509016 | bayes_pls_golite062009 |
| protein complex binding | 0.343240719858581 | bayes_pls_golite062009 |
| insulin receptor binding | 0.266450215230107 | bayes_pls_golite062009 |
| cation channel activity | 0.245400615103891 | bayes_pls_golite062009 |
| SH2 domain binding | 0.226760162354251 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 0.0922946791401962 | bayes_pls_golite062009 |
| transmembrane receptor protein kinase activity | 0.0556163711947139 | bayes_pls_golite062009 |
| transmembrane receptor activity | 0.00652065412910241 | bayes_pls_golite062009 |
| nucleoside-triphosphatase activity | 0.0040394359628233 | bayes_pls_golite062009 |
|
Region A: Residues: [1061-1115] |
1 11 21 31 41 51
| | | | | |
1 HFMDLPEDIA ELMGPVPDGF YDYFTKRFPN LLIGVYMIVK ENLSDDQILR EFLYS
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
