YRC Public Data Repository - Protein Structure Prediction

Protein:	YHB1
Organism:	Saccharomyces cerevisiae
Length:	399 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YHB1.

Description	E-value	Query Range	Subject Range
gi\|729488 - gi\|729488\|sp\|P39676\|FHP_YEAST Flavohemoprotein (Hemoglobin-like protein) (Flavohemoglobin) (Nitric o...	0.0	[1..399]	[1..399]
HMP_BACHD - Flavohemoprotein OS=Bacillus halodurans GN=hmp PE=3 SV=1 HMP_BACHD - Flavohemoprotein OS=Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-...	0.0	[2..397]	[6..409]
HMP_RHIME - Flavohemoprotein OS=Rhizobium meliloti GN=hmp PE=3 SV=2 HMP_RHIME - Flavohemoprotein OS=Rhizobium meliloti (strain 1021) GN=hmp PE=3 SV=2	9.0E-97	[1..394]	[1..400]
gi\|77632889, gi\|... - gi\|77632889\|ref\|ZP_00795063.1\| COG1018: Flavodoxin reductases (ferredoxin-NADPH reductases) family 1... Q667X0\|Q667X0_YERPS - Flavohemoprotein - Yersinia pseudotuberculosis gi\|169750044, gi... - gi\|170023510\|ref\|YP_001720015.1\| nitric oxide dioxygenase [Yersinia pseudotuberculosis YPIII], gi\|16... gi\|149365367, gi... - gi\|149365367\|ref\|ZP_01887402.1\| flavohemoprotein [Yersinia pestis CA88-4125], gi\|149291780\|gb\|EDM418... gi\|167057900, gi... - gi\|167423730\|ref\|ZP_02315483.1\| flavohemoprotein [Yersinia pestis biovar Mediaevalis str. K1973002],... gi\|145211220, gi... - gi\|145599524\|ref\|YP_001163600.1\| nitric oxide dioxygenase [Yersinia pestis Pestoides F], gi\|14521122... gi\|186699307, gi... - gi\|186896281\|ref\|YP_001873393.1\| nitric oxide dioxygenase [Yersinia pseudotuberculosis PB1/+], gi\|18... gi\|229681575, gi... - gi\|229901646\|ref\|ZP_04516768.1\| bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2 [... gi\|165928242, gi... - gi\|165928242\|ref\|ZP_02224074.1\| flavohemoprotein [Yersinia pestis biovar Orientalis str. F1991016], ... gi\|166212488, gi... - gi\|166212488\|ref\|ZP_02238523.1\| flavohemoprotein [Yersinia pestis biovar Antiqua str. B42003004], gi... gi\|166008561, gi... - gi\|166008561\|ref\|ZP_02229459.1\| flavohemoprotein [Yersinia pestis biovar Antiqua str. E1979001], gi\|... gi\|45442327, gi\|... - gi\|45442327\|ref\|NP_993866.1\| nitric oxide dioxygenase [Yersinia pestis biovar Microtus str. 91001], ... gi\|89105654, gi\|... - gi\|89105654\|ref\|ZP_01178169.1\| COG1018: Flavodoxin reductases (ferredoxin-NADPH reductases) family 1... gi\|167421376, gi... - gi\|167421376\|ref\|ZP_02313129.1\| flavohemoprotein [Yersinia pestis biovar Orientalis str. MG05-1020],... gi\|21958088, gi\|... - gi\|22125220\|ref\|NP_668643.1\| nitric oxide dioxygenase [Yersinia pestis KIM], gi\|21958088\|gb\|AAM84894... gi\|108808342, gi... - gi\|108808342\|ref\|YP_652258.1\| nitric oxide dioxygenase [Yersinia pestis Antiqua], gi\|108780255\|gb\|AB... gi\|167051667, gi... - gi\|167399163\|ref\|ZP_02304687.1\| flavohemoprotein [Yersinia pestis biovar Antiqua str. UG05-0454], gi... gi\|218929967, gi... - gi\|218929967\|ref\|YP_002347842.1\| nitric oxide dioxygenase [Yersinia pestis CO92], gi\|16123099\|ref\|NP... gi\|51590468, gi\|... - gi\|51597186\|ref\|YP_071377.1\| nitric oxide dioxygenase [Yersinia pseudotuberculosis IP 32953], gi\|515... HMP_YERPE - Flavohemoprotein OS=Yersinia pestis GN=hmp PE=3 SV=1 gi\|229838492, gi... - gi\|229838492\|ref\|ZP_04458651.1\| bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2 [... gi\|229701302, gi... - gi\|229895496\|ref\|ZP_04510667.1\| bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2 [... gi\|229899062, gi... - gi\|229899062\|ref\|ZP_04514206.1\| bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2 [...	1.0E-96	[1..393]	[1..393]
FHBA_DICDI - Flavohemoprotein A OS=Dictyostelium discoideum GN=fhbA PE=2 SV=1 gi\|60462972, gi\|... - gi\|66801393\|ref\|XP_629622.1\| flavohemoglobin [Dictyostelium discoideum AX4], gi\|60462972\|gb\|EAL61168...	5.0E-95	[2..392]	[3..393]
HMP_VIBPA - Flavohemoprotein OS=Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) GN=hmp PE=3 SV=2 HMP_VIBPA - Flavohemoprotein OS=Vibrio parahaemolyticus GN=hmp PE=3 SV=2	4.0E-94	[1..393]	[1..391]
HMP_ALCEU - (P39662) Flavohemoprotein (Hemoglobin-like protein) (Flavohemoglobin) (FHP) (Nitric oxide dioxygenas... HMP_RALEU - (P39662) Flavohemoprotein (Hemoglobin-like protein) (Flavohemoglobin) (FHP) (Nitric oxide dioxygenas... gi\|460999 - gi\|460999\|emb\|CAA52381.1\| flavohemoprotein [Ralstonia eutropha H16]	9.0E-94	[1..394]	[1..400]
HMP_VIBCH - Flavohemoprotein OS=Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) GN=hmp PE=... gi\|75830965, gi\|... - gi\|75830965\|ref\|ZP_00760234.1\| COG1018: Flavodoxin reductases (ferredoxin-NADPH reductases) family 1... gi\|121629531, gi... - gi\|75816198\|ref\|ZP_00746675.1\| COG1018: Flavodoxin reductases (ferredoxin-NADPH reductases) family 1... gi\|121586716, gi... - gi\|121586716\|ref\|ZP_01676499.1\| ferrisiderophore reductase [Vibrio cholerae 2740-80], gi\|121549013\|g... gi\|227811807, gi... - gi\|227811807\|ref\|YP_002811817.1\| ferrisiderophore reductase [Vibrio cholerae M66-2], gi\|227010949\|gb... HMP_VIBCH - Flavohemoprotein OS=Vibrio cholerae GN=hmp PE=3 SV=1 gi\|124118998, gi... - gi\|153222361\|ref\|ZP_01953111.1\| ferrisiderophore reductase [Vibrio cholerae MAK 757], gi\|124118998\|g... gi\|229506651, gi... - gi\|229506651\|ref\|ZP_04396160.1\| flavohemoprotein [Vibrio cholerae BX 330286], gi\|229357002\|gb\|EEO219... gi\|153816868, gi... - gi\|153816868\|ref\|ZP_01969535.1\| ferrisiderophore reductase [Vibrio cholerae NCTC 8457], gi\|126512671... gi\|229345353, gi... - gi\|229517317\|ref\|ZP_04406762.1\| flavohemoprotein [Vibrio cholerae RC9], gi\|229345353\|gb\|EEO10326.1\| ... gi\|229510551, gi... - gi\|229510551\|ref\|ZP_04400031.1\| flavohemoprotein [Vibrio cholerae B33], gi\|229352996\|gb\|EEO17936.1\| ... gi\|229371614, gi... - gi\|229605128\|ref\|YP_002875832.1\| flavohemoprotein [Vibrio cholerae MJ-1236], gi\|229371614\|gb\|ACQ6203...	2.0E-93	[1..397]	[1..393]

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Predicted Domain #1

Region A:
Residues: [1-72]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLAEKTRSII KATVPVLEQQ GTVITRTFYK NMLTEHTELL NIFNRTNQKV GAQPNALATT  60
   61 VLAAAKNIDD LS

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [94-131]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HYPIVGEYLL KAIKEVLGDA ATPEIINAWG EAYQAIAD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	711.512579
Match:	1cqxA_
Description:	Flavohemoglobin, N-terminal domain; Flavohemoglobin, central domain; Flavohemoglobin, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxygen transporter activity	7.81281381234264	bayes_pls_golite062009
oxygen binding	3.78522064312431	bayes_pls_golite062009
hemoglobin binding	3.17505496298935	bayes_pls_golite062009
transporter activity	2.77225108027137	bayes_pls_golite062009
substrate-specific transporter activity	2.44807175467553	bayes_pls_golite062009
binding	1.56341797572673	bayes_pls_golite062009
catalytic activity	1.45374095556065	bayes_pls_golite062009
hemoglobin alpha binding	1.07662870695556	bayes_pls_golite062009
nitric-oxide synthase activity	0.943011064240739	bayes_pls_golite062009
transferase activity	0.708491789248912	bayes_pls_golite062009
riboflavin synthase activity	0.366634814975673	bayes_pls_golite062009
cofactor binding	0.365255270036622	bayes_pls_golite062009
oxidoreductase activity	0.27336340260908	bayes_pls_golite062009
coenzyme binding	0.270924422726986	bayes_pls_golite062009
protein binding	0.144900113694048	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [73-93]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VLMDHVKQIG HKHRALQIKP E

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [132-260]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IFITVEKKMY EEALWPGWKP FDITAKEYVA SDIVEFTVKP KFGSGIELES LPITPGQYIT  60
   61 VNTHPIRQEN QYDALRHYSL CSASTKNGLR FAVKMEAARE NFPAGLVSEY LHKDAKVGDE 120
  121 IKLSAPAGD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	711.512579
Match:	1cqxA_
Description:	Flavohemoglobin, N-terminal domain; Flavohemoglobin, central domain; Flavohemoglobin, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [261-399]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FAINKELIHQ NEVPLVLLSS GVGVTPLLAM LEEQVKCNPN RPIYWIQSSY DEKTQAFKKH  60
   61 VDELLAECAN VDKIIVHTDT EPLINAAFLK EKSPAHADVY TCGSLAFMQA MIGHLKELEH 120
  121 RDDMIHYEPF GPKMSTVQV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	711.512579
Match:	1cqxA_
Description:	Flavohemoglobin, N-terminal domain; Flavohemoglobin, central domain; Flavohemoglobin, C-terminal domain
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: