YRC Public Data Repository - Protein Structure Prediction

Protein:	SEC53
Organism:	Saccharomyces cerevisiae
Length:	254 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SEC53.

Description	E-value	Query Range	Subject Range
gi\|207345736 - gi\|207345736\|gb\|EDZ72457.1\| YFL045Cp-like protein [Saccharomyces cerevisiae AWRI1631] gi\|190406530 - gi\|190406530\|gb\|EDV09797.1\| phosphomannomutase [Saccharomyces cerevisiae RM11-1a] gi\|151940718 - gi\|151940718\|gb\|EDN59105.1\| phosphomannomutase [Saccharomyces cerevisiae YJM789] PMM_YEAST - Phosphomannomutase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SEC53 PE=1 SV=1 SEC53 - Phosphomannomutase, involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required fo...	0.0	[1..254]	[1..254]
pmm1 - phosphomannomutase Pmm1 PMM_SCHPO - Phosphomannomutase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=pmm1 PE=2 SV=1	0.0	[1..254]	[1..257]
PMM_CANAL - Phosphomannomutase OS=Candida albicans GN=PMM1 PE=1 SV=1 gi\|238879270 - gi\|238879270\|gb\|EEQ42908.1\| phosphomannomutase [Candida albicans WO-1] PMM_CANAL - Phosphomannomutase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PMM1 PE=3 SV=1	0.0	[6..254]	[3..251]
gi\|1813335 - gi\|1813335\|dbj\|BAA19164.1\| phosphomannomutase [Schizosaccharomyces pombe]	0.0	[2..254]	[1..256]
gi\|1655855, gi\|4... - gi\|4505905\|ref\|NP_002667.1\| phosphomannomutase 1 [Homo sapiens], gi\|1655855\|gb\|AAC51117.1\| phosphoma...	0.0	[1..252]	[1..254]
gi\|12833938 - gi\|12833938\|dbj\|BAB22722.1\| unnamed protein product [Mus musculus]	0.0	[14..252]	[3..241]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[5..254]	[13..273]

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Predicted Domain #1

Region A:
Residues: [1-254]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSIAEFAYKE KPETLVLFDV DGTLTPARLT VSEEVRKTLA KLRNKCCIGF VGGSDLSKQL  60
   61 EQLGPNVLDE FDYSFSENGL TAYRLGKELA SQSFINWLGE EKYNKLAVFI LRYLSEIDLP 120
  121 KRRGTFLEFR NGMINVSPIG RNASTEERNE FERYDKEHQI RAKFVEALKK EFPDYGLTFS 180
  181 IGGQISFDVF PAGWDKTYCL QHVEKDGFKE IHFFGDKTMV GGNDYEIFVD ERTIGHSVQS 240
  241 PDDTVKILTE LFNL

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	179.236572
Match:	PF03332
Description:	Eukaryotic phosphomannomutase

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
hydrolase activity	1.86932838801412	bayes_pls_golite062009
phosphatase activity	1.65156839204136	bayes_pls_golite062009
catalytic activity	1.55296860681783	bayes_pls_golite062009
phosphoric ester hydrolase activity	1.45258865666631	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	1.33388154652051	bayes_pls_golite062009
substrate-specific transporter activity	1.31348938920819	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.22591357588429	bayes_pls_golite062009
ion transmembrane transporter activity	1.15184224078831	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions	1.07982919239634	bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity	0.912974008714912	bayes_pls_golite062009
nucleic acid binding	0.911070095136259	bayes_pls_golite062009
binding	0.89911057995199	bayes_pls_golite062009
cation transmembrane transporter activity	0.843430522659521	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.764404472034968	bayes_pls_golite062009
pyrophosphatase activity	0.715824902222533	bayes_pls_golite062009
ATPase activity	0.714770840126679	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.694955044437904	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.693893836676894	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	0.637441292083802	bayes_pls_golite062009
metal ion transmembrane transporter activity	0.527631061477265	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	0.454331447449945	bayes_pls_golite062009
DNA binding	0.452491037562571	bayes_pls_golite062009
ATPase activity, coupled	0.287341673798449	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.197599118916494	bayes_pls_golite062009
active transmembrane transporter activity	0.194344891491143	bayes_pls_golite062009
cation-transporting ATPase activity	0.15490458026932	bayes_pls_golite062009
kinase activity	0.126534028294514	bayes_pls_golite062009
transporter activity	0.1049846678839	bayes_pls_golite062009
primary active transmembrane transporter activity	0.053543166906854	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	0.041293091790546	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.0313681511675771	bayes_pls_golite062009
transmembrane transporter activity	0.00294700699983985	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: