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View Structure Prediction Details

Protein: FRS2
Organism: Saccharomyces cerevisiae
Length: 503 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FRS2.

Description E-value Query
Range
Subject
Range
SYFA_YEAST - Phenylalanine--tRNA ligase alpha subunit OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN...
FRS2 - Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form activ...
0.0 [1..503] [1..503]
FARSA - phenylalanyl-tRNA synthetase, alpha subunit
gi|123994479, gi... - gi|60655947|gb|AAX32537.1| phenylalanine-tRNA synthetase-like alpha subunit [synthetic construct], g...
0.0 [1..498] [1..496]
gi|15488801 - gi|15488801|gb|AAH13533.1| Farsa protein [Mus musculus]
0.0 [1..500] [1..497]
SYFA_ARATH - Phenylalanine--tRNA ligase alpha subunit, cytoplasmic OS=Arabidopsis thaliana GN=At4g39280 PE=2 SV=3
0.0 [9..499] [10..474]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [28..498] [1..451]
CG2263-PA - This gene is referred to in FlyBase by the symbol Dmel\CG2263 (CG2263, FBgn0030007). It is a protein...
gi|220944932, gi... - gi|220954698|gb|ACL89892.1| CG2263-PA [synthetic construct], gi|220944932|gb|ACL85009.1| CG2263-PA [...
0.0 [7..500] [8..498]

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Predicted Domain #1
Region A:
Residues: [1-114]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDFQLEILK KLDELDEIKS TLATFPQHGS QDVLSALNSL KAHNKLEFSK VDTVTYDLTK  60
   61 EGAQILNEGS YEIKLVKLIQ ELGQLQIKDV MSKLGPQVGK VGQARAFKNG WIAK

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 9.66
Match: 1lnwA
Description: MexR repressor
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [115-503]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NASNELELSA KLQNTDLNEL TDETQSILAQ IKNNSHLDSI DAKILNDLKK RKLIAQGKIT  60
   61 DFNVTKGPEF STDLTKLETD LTSDMVSTNA YKDLKFKPYN FNSQGVQISS GALHPLNKVR 120
  121 EEFRQIFFSM GFTEMPSNQY VETGFWNFDA LYVPQQHPAR DLQDTFYIKD PLTADLPDDK 180
  181 TYMDNIKAVH EQGRFGSIGY RYNWKPEECQ KLVLRTHSTA ISARMLHDLA KDPKPTRLFS 240
  241 IDRVFRNEAV DATHLAEFHQ VEGVLADYNI TLGDLIKFME EFFERMGVTG LRFKPTYNPY 300
  301 TEPSMEIFSW HEGLQKWVEI GNSGMFRPEM LESMGLPKDL RVLGWGLSLE RPTMIKYKVQ 360
  361 NIRELLGHKV SLDFIETNPA ARLDEDLYE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 383.228787
Match: 1b70A_
Description: Phenyl-tRNA synthetase (PheRS) alpha subunit, PheS
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phenylalanine-tRNA ligase activity 13.8919118344182 bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds 12.5698315343202 bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds 12.5698315343202 bayes_pls_golite062009
aminoacyl-tRNA ligase activity 12.5592545638101 bayes_pls_golite062009
ligase activity 6.92073480193262 bayes_pls_golite062009
glycine-tRNA ligase activity 2.61548498770105 bayes_pls_golite062009
threonine-tRNA ligase activity 2.18642354927 bayes_pls_golite062009
serine-tRNA ligase activity 2.07594942154162 bayes_pls_golite062009
catalytic activity 1.99372273395202 bayes_pls_golite062009
alanine-tRNA ligase activity 1.82594054955281 bayes_pls_golite062009
lysine-tRNA ligase activity 1.72324031407565 bayes_pls_golite062009
histidine-tRNA ligase activity 1.72215103383322 bayes_pls_golite062009
asparagine-tRNA ligase activity 0.921492123574877 bayes_pls_golite062009
binding 0.705666054154871 bayes_pls_golite062009
aspartate-tRNA ligase activity 0.00572514744734753 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle