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View Structure Prediction Details

Protein: SLD5
Organism: Saccharomyces cerevisiae
Length: 294 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SLD5.

Description E-value Query
Range
Subject
Range
SLD5_YEAST - DNA replication complex GINS protein SLD5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) G...
SLD5 - Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication orig...
0.0 [1..294] [1..294]
SLD5_MOUSE - DNA replication complex GINS protein SLD5 OS=Mus musculus GN=Gins4 PE=1 SV=1
3.0E-70 [50..294] [17..223]
GINS4 - GINS complex subunit 4 (Sld5 homolog)
1.0E-68 [50..294] [17..223]
sld5 - GINS complex subunit Sld5
SLD5_SCHPO - DNA replication complex GINS protein sld5 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=...
8.0E-60 [48..294] [4..214]
gi|194123042, gi... - gi|195349633|ref|XP_002041347.1| GM10199 [Drosophila sechellia], gi|194123042|gb|EDW45085.1| GM10199...
Sld5-PA - The gene Sld5 is referred to in FlyBase by the symbol Dmel\Sld5 (CG14549, FBgn0039403). It is a prot...
7.0E-59 [45..294] [24..228]
CE23303 - WBGene00013768 status:Predicted TR:Q9U2W9 protein_id:CAB54336.1
8.0E-38 [44..199] [11..141]
gi|19074599, gi|... - gi|19074599|ref|NP_586105.1| hypotheticalprotein v26.11 [Encephalitozoon cuniculi GB-M1], gi|1906924...
gi|19074599 - gi|19074599|ref|NP_586105.1| hypotheticalprotein v26.11 [Encephalitozoon cuniculi GB-M1]
0.007 [60..192] [6..106]

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Predicted Domain #1
Region A:
Residues: [1-27]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDINIDDILA ELDKETTAVD STKITQG

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [133-233]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LERLKFVIRS YIRCRLSKID KFSLYLRQLN EDENSLISLT DLLSKDEIKY HDTHSLIWLK  60
   61 LVNDSILKYM PEELQAINDT EGSVNMIDEP DWNKFVFIHV N

[Run NCBI BLAST on this sequence.]

Detection Method: Pcons
Confidence: 2.47
Match: 1dg3A
Description: Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain; Interferon-induced guanylate-binding protein 1 (GBP1), N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
3'-5' DNA helicase activity 3.30007058745861 bayes_pls_golite062009
DNA helicase activity 2.7662250039458 bayes_pls_golite062009
binding 1.86366637427031 bayes_pls_golite062009
protein binding 1.52285169518311 bayes_pls_golite062009
transcription regulator activity 1.2336233528067 bayes_pls_golite062009
helicase activity 1.2110072302388 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.406116199163083 bayes_pls_golite062009
transcription elongation regulator activity 0.37490315580617 bayes_pls_golite062009
pyrophosphatase activity 0.350000641617868 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.33576520693158 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.333445385039412 bayes_pls_golite062009
catalytic activity 0.161911144249814 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [28-132]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSSTTHRDAN TIVGSSLDLN DKTQIYVSPQ QDFSDLMKSW KNERCSPELL PYPHQLMKRL  60
   61 LNRISMQSQL IENISMGFLD MQNASNANPP MPNESKLPLL CMETE

[Run NCBI BLAST on this sequence.]

Detection Method: Pcons
Confidence: 2.47
Match: 1dg3A
Description: Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain; Interferon-induced guanylate-binding protein 1 (GBP1), N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [234-294]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GPPDGKWNED PLLQENEFGK PCYTVTIPDL KEEVELTIGS IYVMRYEVIR DLLRDDKVAL  60
   61 I

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle