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View Structure Prediction Details

Protein: RKM2
Organism: Saccharomyces cerevisiae
Length: 479 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RKM2.

Description E-value Query
Range
Subject
Range
RKM2 - Ribosomal protein lysine methyltransferase, responsible for trimethylation of the lysine residue at ...
RKM2_YEAST - Ribosomal lysine N-methyltransferase 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=R...
gi|207346596 - gi|207346596|gb|EDZ73046.1| YDR198Cp-like protein [Saccharomyces cerevisiae AWRI1631]
gi|190404847 - gi|190404847|gb|EDV08114.1| lysine methyltransferase [Saccharomyces cerevisiae RM11-1a]
gi|151942181 - gi|151942181|gb|EDN60537.1| lysine methyltransferase [Saccharomyces cerevisiae YJM789]
0.0 [1..479] [1..479]
RBCMT_TOBAC - Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic OS=...
3.0E-84 [42..472] [43..450]
RBCMT_ARATH - [Fructose-bisphosphate aldolase]-lysine N-methyltransferase, chloroplastic OS=Arabidopsis thaliana G...
3.0E-84 [52..472] [45..441]
SETD3_MOUSE - Histone-lysine N-methyltransferase setd3 OS=Mus musculus GN=Setd3 PE=1 SV=1
3.0E-84 [25..473] [38..478]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
2.0E-83 [37..472] [39..449]
RBCMT_PEA - Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic OS=...
7.0E-81 [37..472] [35..446]
SETD4 - SET domain containing 4
3.0E-79 [8..479] [36..434]

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Predicted Domain #1
Region A:
Residues: [1-357]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEGKVDVLLT WLKKSDKFYI APNISICESP ETGRGIVLSH GSIRKNDIIV SVPSSKQLNF  60
   61 HTILYHISKF NKELNIPGIT IDRKPINYED NIIEAENKAW ADPRYGLYSE LSKEFLLSLS 120
  121 SFQLVSFYIL VENFLLPKWT HNEIYSDWKP FFDVWPSMEE LRSIPAIWNC DPNSRYHSLI 180
  181 EYLPAASRKH MARISGLVRE DWETISEVVL KWNEIYGSLS CTKNSDKFTS DELFSLFVHV 240
  241 YFIINSRCLY AKIPLKIEDS PSNFTLVPYV DFMNHICESD LHCYPQLSPQ LRSEGENIIG 300
  301 IGQFTIRCGD HLYDNINEEL FLNYGAHSND FLLNEYGFVV DGNKWNYLDI SDEIIEL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
protein methyltransferase activity 5.17416737778891 bayes_pls_golite062009
histone methyltransferase activity 5.11922117538134 bayes_pls_golite062009
lysine N-methyltransferase activity 4.38975149400874 bayes_pls_golite062009
protein-lysine N-methyltransferase activity 4.38975149400874 bayes_pls_golite062009
histone-lysine N-methyltransferase activity 4.38975149400874 bayes_pls_golite062009
N-methyltransferase activity 2.95997850922356 bayes_pls_golite062009
histone methyltransferase activity (H3-K9 specific) 2.79558337306904 bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity 2.69428385009711 bayes_pls_golite062009
methyltransferase activity 2.33114816345072 bayes_pls_golite062009
transferase activity, transferring one-carbon groups 2.25175257044903 bayes_pls_golite062009
protein binding 0.819746654455251 bayes_pls_golite062009
binding 0.773331253307132 bayes_pls_golite062009
transferase activity 0.653108419761009 bayes_pls_golite062009
catalytic activity 0.414641636618101 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [358-479]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IDDDKKEVKT FLLEHDYWGD YTINETDISY RIFVALNYYV TRDERRVRKF IEGYISEDYF  60
   61 KPKISSVLKE LLVSLTAKYT KTLSELTEKV SNLENNLCLQ NLITIYKGYI KILTQHLQDL 120
  121 QS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.938 a.29.5 alpha-ketoacid dehydrogenase kinase, N-terminal domain


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle