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View Structure Prediction Details

Protein: RKM2
Organism: Saccharomyces cerevisiae
Length: 479 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RKM2.

Description E-value Query
Range
Subject
Range
RKM2 - Ribosomal protein lysine methyltransferase, responsible for trimethylation of the lysine residue at ...
RKM2_YEAST - Ribosomal lysine N-methyltransferase 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=R...
gi|207346596 - gi|207346596|gb|EDZ73046.1| YDR198Cp-like protein [Saccharomyces cerevisiae AWRI1631]
gi|190404847 - gi|190404847|gb|EDV08114.1| lysine methyltransferase [Saccharomyces cerevisiae RM11-1a]
gi|151942181 - gi|151942181|gb|EDN60537.1| lysine methyltransferase [Saccharomyces cerevisiae YJM789]
0.0 [1..479] [1..479]
RBCMT_TOBAC - Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic OS=...
3.0E-84 [42..472] [43..450]
RBCMT_ARATH - [Fructose-bisphosphate aldolase]-lysine N-methyltransferase, chloroplastic OS=Arabidopsis thaliana G...
3.0E-84 [52..472] [45..441]
SETD3_MOUSE - Histone-lysine N-methyltransferase setd3 OS=Mus musculus GN=Setd3 PE=1 SV=1
3.0E-84 [25..473] [38..478]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
2.0E-83 [37..472] [39..449]
RBCMT_PEA - Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic OS=...
7.0E-81 [37..472] [35..446]
SETD4 - SET domain containing 4
3.0E-79 [8..479] [36..434]

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Predicted Domain #1
Region A:
Residues: [1-357]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEGKVDVLLT WLKKSDKFYI APNISICESP ETGRGIVLSH GSIRKNDIIV SVPSSKQLNF  60
   61 HTILYHISKF NKELNIPGIT IDRKPINYED NIIEAENKAW ADPRYGLYSE LSKEFLLSLS 120
  121 SFQLVSFYIL VENFLLPKWT HNEIYSDWKP FFDVWPSMEE LRSIPAIWNC DPNSRYHSLI 180
  181 EYLPAASRKH MARISGLVRE DWETISEVVL KWNEIYGSLS CTKNSDKFTS DELFSLFVHV 240
  241 YFIINSRCLY AKIPLKIEDS PSNFTLVPYV DFMNHICESD LHCYPQLSPQ LRSEGENIIG 300
  301 IGQFTIRCGD HLYDNINEEL FLNYGAHSND FLLNEYGFVV DGNKWNYLDI SDEIIEL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term Confidence Notes
protein methyltransferase activity 5.17416737778891 bayes_pls_golite062009
histone methyltransferase activity 5.11922117538134 bayes_pls_golite062009
lysine N-methyltransferase activity 4.38975149400874 bayes_pls_golite062009
protein-lysine N-methyltransferase activity 4.38975149400874 bayes_pls_golite062009
histone-lysine N-methyltransferase activity 4.38975149400874 bayes_pls_golite062009
N-methyltransferase activity 2.95997850922356 bayes_pls_golite062009
histone methyltransferase activity (H3-K9 specific) 2.79558337306904 bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity 2.69428385009711 bayes_pls_golite062009
methyltransferase activity 2.33114816345072 bayes_pls_golite062009
transferase activity, transferring one-carbon groups 2.25175257044903 bayes_pls_golite062009
protein binding 0.819746654455251 bayes_pls_golite062009
binding 0.773331253307132 bayes_pls_golite062009
transferase activity 0.653108419761009 bayes_pls_golite062009
catalytic activity 0.414641636618101 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [358-479]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IDDDKKEVKT FLLEHDYWGD YTINETDISY RIFVALNYYV TRDERRVRKF IEGYISEDYF  60
   61 KPKISSVLKE LLVSLTAKYT KTLSELTEKV SNLENNLCLQ NLITIYKGYI KILTQHLQDL 120
  121 QS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.938 a.29.5 alpha-ketoacid dehydrogenase kinase, N-terminal domain
View Download 0.931 a.47.2 t-snare proteins
View Download 0.928 a.7.7 BAG domain
View Download 0.926 a.7.8 GAT domain
View Download 0.871 a.7.4 Smac/diablo
View Download 0.825 a.29.5 alpha-ketoacid dehydrogenase kinase, N-terminal domain
View Download 0.813 a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.809 a.47.2 t-snare proteins
View Download 0.724 a.25.1 Ferritin-like
View Download 0.723 a.7.1 Spectrin repeat
View Download 0.715 f.18.1 F1F0 ATP synthase subunit A
View Download 0.691 a.24.3 Cytochromes
View Download 0.641 a.24.9 alpha-catenin/vinculin
View Download 0.639 a.7.1 Spectrin repeat
View Download 0.620 i.11.1 Computational models partly based on NMR data
View Download 0.591 a.25.1 Ferritin-like
View Download 0.586 d.67.3 Ribosome recycling factor, RRF
View Download 0.585 a.24.1 Apolipoprotein
View Download 0.582 a.25.1 Ferritin-like
View Download 0.580 a.24.14 FAT domain of focal adhesion kinase
View Download 0.573 a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.556 a.25.1 Ferritin-like
View Download 0.543 a.47.2 t-snare proteins
View Download 0.537 a.7.5 Tubulin chaperone cofactor A
View Download 0.530 a.24.3 Cytochromes
View Download 0.521 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.516 f.1.3 delta-Endotoxin (insectocide), N-terminal domain
View Download 0.515 a.24.3 Cytochromes
View Download 0.511 a.24.9 alpha-catenin/vinculin
View Download 0.506 a.46.1 Methionine synthase domain
View Download 0.493 a.78.1 Fatty acid responsive transcription factor FadR, C-terminal domain
View Download 0.483 f.25.1 Cytochrome c oxidase subunit III-like
View Download 0.483 a.63.1 Apolipophorin-III
View Download 0.476 a.25.1 Ferritin-like
View Download 0.457 a.25.1 Ferritin-like
View Download 0.445 f.13.1 Family A G protein-coupled receptor-like
View Download 0.444 f.21.2 Fumarate reductase respiratory complex transmembrane subunits
View Download 0.438 a.24.3 Cytochromes
View Download 0.421 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.402 a.4.12 TrpR-like
View Download 0.389 a.37.1 A DNA-binding domain in eukaryotic transcription factors
View Download 0.388 a.133.1 Phospholipase A2, PLA2
View Download 0.386 a.62.1 Hepatitis B viral capsid (hbcag)
View Download 0.378 a.24.9 alpha-catenin/vinculin
View Download 0.372 d.188.1 Prokaryotic ribosomal protein L17
View Download 0.372 d.198.1 Type III secretory system chaperone
View Download 0.368 d.87.2 CO dehydrogenase flavoprotein C-terminal domain-like
View Download 0.367 a.29.2 Bromodomain
View Download 0.360 a.4.5 "Winged helix" DNA-binding domain
View Download 0.345 d.13.1 HIT-like
View Download 0.338 a.118.10 Phosphoinositide-binding clathrin adaptor, N-terminal domain
View Download 0.338 c.110.1 D-Tyr tRNAtyr deacylase, DTD
View Download 0.333 a.118.9 ENTH/VHS domain
View Download 0.332 a.60.10 Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain
View Download 0.327 a.118.7 14-3-3 protein
View Download 0.327 a.24.4 Hemerythrin
View Download 0.324 a.4.1 Homeodomain-like
View Download 0.318 a.48.2 Transferrin receptor ectodomain, C-terminal domain
View Download 0.313 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.304 a.29.4 RecG, N-terminal domain
View Download 0.301 d.198.1 Type III secretory system chaperone
View Download 0.295 f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.295 a.22.1 Histone-fold
View Download 0.294 a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.293 d.110.4 SNARE-like
View Download 0.289 a.63.1 Apolipophorin-III
View Download 0.289 a.118.8 TPR-like
View Download 0.283 a.19.1 Fertilization protein
View Download 0.282 d.13.1 HIT-like
View Download 0.278 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.277 a.40.1 Calponin-homology domain, CH-domain
View Download 0.276 a.29.2 Bromodomain
View Download 0.274 d.74.3 RBP11-like subunits of RNA polymerase
View Download 0.272 a.30.2 Homodimeric domain of signal transducing histidine kinase
View Download 0.264 a.2.7 tRNA-binding arm
View Download 0.264 a.2.11 Fe,Mn superoxide dismutase (SOD), N-terminal domain
View Download 0.262 a.24.2 Aspartate receptor, ligand-binding domain
View Download 0.262 a.118.9 ENTH/VHS domain
View Download 0.260 d.54.1 Enolase N-terminal domain-like
View Download 0.254 a.25.2 Thermoplasma ferritin-like 4-helical bundle
View Download 0.254 d.58.27 Translational regulator protein regA
View Download 0.254 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.252 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.251 d.56.1 GroEL-intermediate domain like
View Download 0.245 f.21.2 Fumarate reductase respiratory complex transmembrane subunits
View Download 0.244 a.26.1 4-helical cytokines
View Download 0.243 a.4.5 "Winged helix" DNA-binding domain
View Download 0.241 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.241 d.16.1 FAD-linked reductases, C-terminal domain
View Download 0.238 d.14.1 Ribosomal protein S5 domain 2-like
View Download 0.237 a.26.1 4-helical cytokines
View Download 0.234 a.7.3 Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
View Download 0.232 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.226 a.156.1 S13-like H2TH domain
View Download 0.225 a.48.1 N-terminal domain of cbl (N-cbl)
View Download 0.224 a.177.1 Sigma2 domain of RNA polymerase sigma factors
View Download 0.220 d.74.5 Hypothetical protein Yml108w
View Download 0.218 a.4.5 "Winged helix" DNA-binding domain
View Download 0.216 d.228.1 Replication modulator SeqA, C-terminal DNA-binding domain
View Download 0.210 a.128.1 Terpenoid synthases
View Download 0.209 a.1.1 Globin-like
View Download 0.208 a.1.1 Globin-like
View Download 0.207 f.1.3 delta-Endotoxin (insectocide), N-terminal domain
View Download 0.207 a.73.1 Retrovirus capsid protein, N-terminal core domain
View Download 0.204 a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.203 a.24.17 Group V grass pollen allergen
View Download 0.203 a.71.2 Helical domain of Sec23/24


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle