YRC Public Data Repository - Protein Structure Prediction

Protein:	KGD2
Organism:	Saccharomyces cerevisiae
Length:	463 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for KGD2.

Description	E-value	Query Range	Subject Range
ODO2_YEAST - Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, m... gi\|190404894 - gi\|190404894\|gb\|EDV08161.1\| hypothetical protein SCRG_00372 [Saccharomyces cerevisiae RM11-1a] KGD2 - Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase com...	0.0	[1..463]	[1..463]
gi\|227010100, gi... - gi\|227082212\|ref\|YP_002810763.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succin... gi\|229507825, gi... - gi\|229507825\|ref\|ZP_04397330.1\| dihydrolipoamide succinyltransferase component (E2) of 2-oxoglutarat... gi\|9656634, gi\|1... - gi\|9656634\|gb\|AAF95232.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltrans... gi\|229343763, gi... - gi\|229519074\|ref\|ZP_04408517.1\| dihydrolipoamide succinyltransferase component (E2) of 2-oxoglutarat... gi\|229607370, gi... - gi\|229607370\|ref\|YP_002878018.1\| dihydrolipoamide succinyltransferase component (E2) of 2-oxoglutara... gi\|75829400, gi\|... - gi\|75829400\|ref\|ZP_00758704.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|147675118, gi... - gi\|75827393\|ref\|ZP_00756828.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|121727380, gi... - gi\|75814758\|ref\|ZP_00745311.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|121586902, gi... - gi\|121586902\|ref\|ZP_01676682.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny... gi\|124119054, gi... - gi\|153222194\|ref\|ZP_01952973.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny... gi\|153818382, gi... - gi\|153818382\|ref\|ZP_01971049.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny... gi\|11257428 - pir\|\|A82121 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase VC2086 ... gi\|229351903, gi... - gi\|229511938\|ref\|ZP_04401417.1\| dihydrolipoamide succinyltransferase component (E2) of 2-oxoglutarat...	0.0	[72..462]	[1..402]
gi\|186697571, gi... - gi\|186894545\|ref\|YP_001871657.1\| dihydrolipoamide succinyltransferase [Yersinia pseudotuberculosis P... gi\|169751723, gi... - gi\|170025189\|ref\|YP_001721694.1\| dihydrolipoamide succinyltransferase [Yersinia pseudotuberculosis Y... gi\|165924674, gi... - gi\|165924674\|ref\|ZP_02220506.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny... gi\|21959982, gi\|... - gi\|22126942\|ref\|NP_670365.1\| dihydrolipoamide acetyltransferase [Yersinia pestis KIM], gi\|21959982\|g... gi\|166211260, gi... - gi\|166211260\|ref\|ZP_02237295.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny... gi\|25286448 - pir\|\|AB0137 dihydrolipoamide S-succinyltransferase (EC 2.3.1.61) [imported] - Yersinia pestis (strai... gi\|166011609, gi... - gi\|166011609\|ref\|ZP_02232507.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny... gi\|51595492, gi\|... - gi\|51595492\|ref\|YP_069683.1\| dihydrolipoamide acetyltransferase [Yersinia pseudotuberculosis IP 3295... gi\|166962232, gi... - gi\|167419491\|ref\|ZP_02311244.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny... gi\|45435734, gi\|... - gi\|45440876\|ref\|NP_992415.1\| dihydrolipoamide acetyltransferase [Yersinia pestis biovar Microtus str... gi\|167050555, gi... - gi\|167399847\|ref\|ZP_02305365.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny... gi\|167468939 - gi\|167468939\|ref\|ZP_02333643.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny... gi\|218928282, gi... - gi\|218928282\|ref\|YP_002346157.1\| dihydrolipoamide succinyltransferase [Yersinia pestis CO92], gi\|161... gi\|167057125, gi... - gi\|167424276\|ref\|ZP_02316029.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny... gi\|77636427, gi\|... - gi\|77636427\|ref\|ZP_00798501.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|77632107, gi\|... - gi\|77632107\|ref\|ZP_00794693.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|149291260, gi... - gi\|149366886\|ref\|ZP_01888920.1\| dihydrolipoamide succinyltransferase component of 2-oxoglutarate deh... gi\|145599848, gi... - gi\|145599848\|ref\|YP_001163924.1\| dihydrolipoamide acetyltransferase [Yersinia pestis Pestoides F], g... Q66DA1\|Q66DA1_YERPS - Dihydrolipoamide succinyltransferase component of 2-oxoglutar... - Yersinia pseudotuberculosis gi\|89105201, gi\|... - gi\|89105201\|ref\|ZP_01177725.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|108806589, gi... - gi\|108806589\|ref\|YP_650505.1\| dihydrolipoamide acetyltransferase [Yersinia pestis Antiqua], gi\|10877... gi\|229697416, gi... - gi\|229841050\|ref\|ZP_04461209.1\| dihydrolipoyltranssuccinase [Yersinia pestis biovar Orientalis str. ... gi\|229843154, gi... - gi\|229843154\|ref\|ZP_04463300.1\| dihydrolipoyltranssuccinase [Yersinia pestis biovar Orientalis str. ... gi\|229703876, gi... - gi\|229893991\|ref\|ZP_04509177.1\| dihydrolipoyltranssuccinase [Yersinia pestis Pestoides A], gi\|229703... gi\|229903485, gi... - gi\|229903485\|ref\|ZP_04518598.1\| dihydrolipoyltranssuccinase [Yersinia pestis Nepal516], gi\|229679255...	0.0	[71..462]	[1..405]
gi\|15602143, gi\|... - gi\|15602143\|ref\|NP_245215.1\| hypothetical protein PM0278 [Pasteurella multocida subsp. multocida str...	0.0	[71..462]	[1..402]
gi\|73854728, gi\|... - gi\|74311251\|ref\|YP_309670.1\| dihydrolipoamide acetyltransferase [Shigella sonnei Ss046], gi\|73854728... gi\|168777543, gi... - gi\|187767227\|gb\|EDU31071.1\| dihydrolipoyllysine-residue succinyltransferase, E2 component of oxoglut... gi\|194421839, gi... - gi\|83585342\|ref\|ZP_00923989.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|189002966, gi... - gi\|189002966\|gb\|EDU71952.1\| dihydrolipoyllysine-residue succinyltransferase, E2 component of oxoglut... gi\|189372983, gi... - gi\|189372983\|gb\|EDU91399.1\| dihydrolipoyllysine-residue succinyltransferase, E2 component of oxoglut... gi\|189376474, gi... - gi\|189376474\|gb\|EDU94890.1\| dihydrolipoyllysine-residue succinyltransferase, E2 component of oxoglut... gi\|193070661, gi... - gi\|75234495\|ref\|ZP_00718842.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|170020929, gi... - gi\|170020929\|ref\|YP_001725883.1\| dihydrolipoamide succinyltransferase [Escherichia coli ATCC 8739], ... gi\|75511614, gi\|... - gi\|75511614\|ref\|ZP_00734265.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|170080393, gi... - gi\|170080393\|ref\|YP_001729713.1\| dihydrolipoyltranssuccinase [Escherichia coli str. K-12 substr. DH1... gi\|75189748, gi\|... - gi\|75189748\|ref\|ZP_00703015.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|170518735, gi... - gi\|170681017\|ref\|YP_001742827.1\| dihydrolipoyllysine-residue succinyltransferase, E2 component of ox... gi\|75229641, gi\|... - gi\|75229641\|ref\|ZP_00716178.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|194417748, gi... - gi\|194433983\|ref\|ZP_03066254.1\| dihydrolipoyllysine-residue succinyltransferase, E2 component of oxo... gi\|13360210, gi\|... - gi\|15830006\|ref\|NP_308779.1\| dihydrolipoamide succinyltransferase [Escherichia coli O157:H7 str. Sak... gi\|188015221, gi... - gi\|188015221\|gb\|EDU53343.1\| dihydrolipoyllysine-residue succinyltransferase, E2 component of oxoglut... gi\|168757180, gi... - gi\|189355777\|gb\|EDU74196.1\| dihydrolipoyllysine-residue succinyltransferase, E2 component of oxoglut... gi\|189365937, gi... - gi\|189365937\|gb\|EDU84353.1\| dihydrolipoyllysine-residue succinyltransferase, E2 component of oxoglut... gi\|1651322, gi\|8... - gi\|89107584\|ref\|AP_001364.1\| dihydrolipoyltranssuccinase [Escherichia coli str. K-12 substr. W3110],... gi\|189363360, gi... - gi\|189363360\|gb\|EDU81779.1\| dihydrolipoyllysine-residue succinyltransferase, E2 component of oxoglut... gi\|218360021, gi... - gi\|218553253\|ref\|YP_002386166.1\| dihydrolipoamide succinyltransferase [Escherichia coli IAI1], gi\|21... gi\|218369067, gi... - gi\|218699081\|ref\|YP_002406710.1\| dihydrolipoamide succinyltransferase [Escherichia coli IAI39], gi\|2... gi\|254791873, gi... - gi\|254791873\|ref\|YP_003076710.1\| dihydrolipoyltranssuccinase [Escherichia coli O157:H7 str. TW14359]... gi\|253972697, gi... - gi\|254160796\|ref\|YP_003043904.1\| dihydrolipoamide acetyltransferase [Escherichia coli B str. REL606]... gi\|195939068 - gi\|195939068\|ref\|ZP_03084450.1\| dihydrolipoamide acetyltransferase [Escherichia coli O157:H7 str. EC... gi\|253325347, gi... - gi\|254287584\|ref\|YP_003053332.1\| dihydrolipoamide acetyltransferase [Escherichia coli BL21(DE3)], gi... ODO2_ECOLI - Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (E... gi\|208725695, gi... - gi\|208805894\|ref\|ZP_03248231.1\| dihydrolipoyllysine-residue succinyltransferase, E2 component of oxo... gi\|251784215, gi... - gi\|251784215\|ref\|YP_002998519.1\| hypothetical protein B21_00675 [Escherichia coli BL21], gi\|24237648... ODO2_ECO57 - Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex OS... gi\|208815793, gi... - gi\|208815793\|ref\|ZP_03256972.1\| dihydrolipoyllysine-residue succinyltransferase, E2 component of oxo... gi\|238899991, gi... - gi\|238899991\|ref\|YP_002925787.1\| dihydrolipoyltranssuccinase [Escherichia coli BW2952], gi\|238860764... EG10980 - dihydrolipoyltranssuccinase / 2-oxoglutarate dehydrogenase, E2 component; dihydrolipoamide succinylt... gi\|208822873, gi... - gi\|208822873\|ref\|ZP_03263191.1\| dihydrolipoyllysine-residue succinyltransferase, E2 component of oxo... gi\|12513642, gi\|... - gi\|15800431\|ref\|NP_286443.1\| dihydrolipoamide acetyltransferase [Escherichia coli O157:H7 EDL933], g... gi\|209397255, gi... - gi\|209397255\|ref\|YP_002269350.1\| dihydrolipoyllysine-residue succinyltransferase, E2 component of ox... gi\|209917977, gi... - gi\|209917977\|ref\|YP_002292061.1\| dihydrolipoamide succinyltransferase [Escherichia coli SE11], gi\|20... gi\|215263817, gi... - gi\|215485745\|ref\|YP_002328176.1\| dihydrolipoamide succinyltransferase [Escherichia coli O127:H6 str.... gi\|217322317, gi... - gi\|217326096\|ref\|ZP_03442180.1\| dihydrolipoyllysine-residue succinyltransferase, E2 component of oxo... gi\|124526818, gi... - gi\|124526818\|ref\|ZP_01698700.1\| 2-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinylt... EG10980 - dihydrolipoyltranssuccinase / 2-oxoglutarate dehydrogenase, E2 component; dihydrolipoamide succinylt...	0.0	[71..462]	[1..403]
DBT - dihydrolipoamide branched chain transacylase E2 HGNC:2698\|MIM:24... - branched chain transacylase E2 gi\|61359897, gi\|... - gi\|61359903\|gb\|AAX41784.1\| dihydrolipoamide branched chain transacylase [synthetic construct], gi\|61...	0.0	[9..462]	[3..479]
ODO2_RICPR - Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex OS... ODO2_RICPR - Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex OS...	0.0	[72..462]	[1..399]
gi\|15614768, gi\|... - gi\|15614768\|ref\|NP_243071.1\| dihydrolipoamide acetyltransferase [Bacillus halodurans C-125], gi\|1017... gi\|25286430 - pir\|\|E83925 dihydrolipoamide succinyltransferase BH2205 [imported] - Bacillus halodurans (strain C-1...	0.0	[74..462]	[2..409]

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Predicted Domain #1

Region A:
Residues: [1-70]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSRATRTAA AKSLVKSKVA RNVMAASFVK RHASTSLFKQ ANKVESLGSI YLSGKKISVA  60
   61 ANPFSITSNR

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.519	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.546	a.64.1	Saposin
View	Download	0.503	d.74.2	C-terminal domain of arginine repressor
View	Download	0.514	a.64.1	Saposin
View	Download	0.459	a.101.1	Uteroglobin-like
View	Download	0.454	a.52.1	Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View	Download	0.442	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.439	a.24.13	Domain of the SRP/SRP receptor G-proteins
View	Download	0.435	a.159.2	FF domain
View	Download	0.387	g.3.7	Scorpion toxin-like
View	Download	0.380	a.57.1	Protein HNS-dependent expression A; HdeA
View	Download	0.374	a.101.1	Uteroglobin-like
View	Download	0.370	d.95.2	Homing endonucleases
View	Download	0.365	a.101.1	Uteroglobin-like
View	Download	0.357	a.2.8	Eukaryotic DNA topoisomerase I, dispensable insert domain
View	Download	0.340	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.333	d.95.1	Glucose permease domain IIB
View	Download	0.331	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.311	a.77.1	DEATH domain
View	Download	0.308	a.2.7	tRNA-binding arm
View	Download	0.305	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.301	d.26.3	Chitinase insertion domain
View	Download	0.281	d.58.35	Pseudouridine synthase
View	Download	0.279	a.35.1	lambda repressor-like DNA-binding domains
View	Download	0.276	a.4.1	Homeodomain-like
View	Download	0.262	a.39.1	EF-hand
View	Download	0.262	a.24.13	Domain of the SRP/SRP receptor G-proteins
View	Download	0.262	b.85.1	Type III antifreeze protein, AFP III
View	Download	0.261	b.85.1	Type III antifreeze protein, AFP III
View	Download	0.258	a.4.6	C-terminal effector domain of the bipartite response regulators
View	Download	0.255	g.10.1	Hairpin loop containing domain-like
View	Download	0.250	d.39.1	Dynein light chain 8 (DLC8)
View	Download	0.248	f.15.1	Small-conductance potassium channel
View	Download	0.246	d.95.1	Glucose permease domain IIB
View	Download	0.240	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.239	d.95.1	Glucose permease domain IIB
View	Download	0.236	a.77.1	DEATH domain
View	Download	0.232	a.4.1	Homeodomain-like
View	Download	0.228	a.77.1	DEATH domain
View	Download	0.221	a.49.1	C-terminal domain of B transposition protein
View	Download	0.218	a.70.1	N-terminal domain of the delta subunit of the F1F0-ATP synthase
View	Download	0.215	d.68.3	SirA-like
View	Download	0.214	a.4.1	Homeodomain-like

Predicted Domain #2

Region A:
Residues: [71-182]

      1          11         21         31         41         51         
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    1 FKSTSIEVPP MAESLTEGSL KEYTKNVGDF IKEDELLATI ETDKIDIEVN SPVSGTVTKL  60
   61 NFKPEDTVTV GEELAQVEPG EAPAEGSGES KPEPTEQAEP SQGVAARENS SE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	67.9897
Match:	1lab__
Description:	Ipoyl domain of dihydrolipoamide acetyltransferase
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [183-231]

      1          11         21         31         41         51         
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    1 ETASKKEAAP KKEAAPKKEV TEPKKADQPK KTVSKAQEPP VASNSFTPF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	4.09691
Match:	2pdd__
Description:	E3/E1 binding domain of dihydrolipoyl acetyltransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
S-succinyltransferase activity	10.0778678835755	bayes_pls_golite062009
dihydrolipoyllysine-residue succinyltransferase activity	10.0778678835755	bayes_pls_golite062009
S-acyltransferase activity	9.57991961071442	bayes_pls_golite062009
succinyltransferase activity	6.58826720904067	bayes_pls_golite062009
acyltransferase activity	6.14362200989279	bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups	6.13552509992797	bayes_pls_golite062009
dihydrolipoamide S-acyltransferase activity	4.1573115612763	bayes_pls_golite062009
dihydrolipoyllysine-residue acetyltransferase activity	3.95619571226032	bayes_pls_golite062009
transferase activity, transferring acyl groups	3.91600160749755	bayes_pls_golite062009
S-acetyltransferase activity	3.80731268500197	bayes_pls_golite062009
carnitine O-acyltransferase activity	1.95284873022177	bayes_pls_golite062009
catalytic activity	1.51562638409295	bayes_pls_golite062009
pyruvate dehydrogenase activity	1.47989209806246	bayes_pls_golite062009
O-acyltransferase activity	1.33852311685118	bayes_pls_golite062009
acetyltransferase activity	1.12787027896966	bayes_pls_golite062009
transferase activity	1.08341671157927	bayes_pls_golite062009
binding	0.801074244553007	bayes_pls_golite062009
O-palmitoyltransferase activity	0.36133273832704	bayes_pls_golite062009
carnitine O-palmitoyltransferase activity	0.36133273832704	bayes_pls_golite062009
carnitine O-acetyltransferase activity	0.154650266774881	bayes_pls_golite062009
O-acetyltransferase activity	0.1424856707148	bayes_pls_golite062009
protein binding	0.00454070917775817	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [232-463]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PRTETRVKMN RMRLRIAERL KESQNTAASL TTFNEVDMSA LMEMRKLYKD EIIKKTGTKF  60
   61 GFMGLFSKAC TLAAKDIPAV NGAIEGDQIV YRDYTDISVA VATPKGLVTP VVRNAESLSV 120
  121 LDIENEIVRL SHKARDGKLT LEDMTGGTFT ISNGGVFGSL YGTPIINSPQ TAVLGLHGVK 180
  181 ERPVTVNGQI VSRPMMYLAL TYDHRLLDGR EAVTFLKTVK ELIEDPRKML LW

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	870.0
Match:	1c4tA_
Description:	Dihydrolipoamide succinyltransferase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: