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View Structure Prediction Details

Protein: VPS41
Organism: Saccharomyces cerevisiae
Length: 992 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for VPS41.

Description E-value Query
Range		 Subject
Range
VPS41 - Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sort...
VPS41_YEAST - Vacuolar protein sorting-associated protein 41 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S28...
 0.0 [1..992] [1..992]
VPS41_SOLLC - Vacuolar protein sorting-associated protein 41 homolog OS=Solanum lycopersicum GN=VPS41 PE=2 SV=1
 0.0 [74..985] [11..837]
VPS41_ARATH, VP4... - (P93043) Vacuolar assembly protein VPS41 homolog, (P93043) Vacuolar assembly protein VPS41 homolog
 0.0 [74..989] [17..853]
VPS41 - vacuolar protein sorting 41 homolog (S. cerevisiae)
 0.0 [82..983] [11..791]
VPS41_SCHPO - Vacuolar protein sorting-associated protein 41 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843...
vps41 - vacuolar protein sorting-associated protein Vps41
 0.0 [77..977] [2..791]
vps-41 - status:Partially_confirmed UniProt:Q19954 protein_id:AAA81388.3
 0.0 [181..980] [62..759]
gi|57977132, gi|... - gi|74221407|dbj|BAE42179.1| unnamed protein product [Mus musculus], gi|57977132|dbj|BAD88411.1| mVAM...
 0.0 [212..983] [28..841]

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Predicted Domain #1
Region A:
Residues: [1-375] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTDNHQNDS VLDQQSGERT IDESNSISDE NNVDNKREDV NVTSPTKSVS CISQAENGVA  60
   61 SRTDESTITG SATDAETGDD DDDDDDDDDE DEDDEDEPPL LKYTRISQLP KNFFQRDSIS 120
  121 SCLFGDTFFA FGTHSGILHL TTCAFEPIKT IKCHRSSILC INTDGKYFAT GSIDGTVIIG 180
  181 SMDDPQNITQ YDFKRPINSV ALHSNFQASR MFVSGGMAGD VVLSQRNWLG NRIDIVLNKK 240
  241 KKKKTRKDDL SSDMKGPIMG IYTMGDLILW MDDDGITFCD VPTRSQLLNI PFPSRIFNVQ 300
  301 DVRPDLFRPH VHFLESDRVV IGWGSNIWLF KVSFTKDSNS IKSGDSNSQS NNMSHFNPTT 360
  361 NIGSLLSSAA SSFRG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 57.0
Match: 1erjA_
Description: Tup1, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cytoskeletal protein binding 2.20122168933317 bayes_pls_golite062009
binding 1.99637157021613 bayes_pls_golite062009
actin binding 1.40054662654509 bayes_pls_golite062009
protein binding 1.21879977456466 bayes_pls_golite062009
transporter activity 1.21549336905926 bayes_pls_golite062009
tubulin binding 1.10875870970504 bayes_pls_golite062009
microtubule binding 1.03769395387791 bayes_pls_golite062009
substrate-specific transporter activity 0.734793983890004 bayes_pls_golite062009
nucleic acid binding 0.624115832843391 bayes_pls_golite062009
hydrolase activity 0.36638536879917 bayes_pls_golite062009
transcription repressor activity 0.328276176504109 bayes_pls_golite062009
transcription regulator activity 0.282387003961579 bayes_pls_golite062009
dynein binding 0.180120691665679 bayes_pls_golite062009
structural molecule activity 0.0588151480189092 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.00585398682921312 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [376-478] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TPDKKVELEC HFTVSMLITG LASFKDDQLL CLGFDIDIEE EATIDEDMKE GKNFSKRPEN  60
   61 LLAKGNAPEL KIVDLFNGDE IYNDEVIMKN YEKLSINDYH LGK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 68.30103
Match: 1gg2B_
Description: beta1-subunit of the signal-transducing G protein heterotrimer
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cytoskeletal protein binding 2.20122168933317 bayes_pls_golite062009
binding 1.99637157021613 bayes_pls_golite062009
actin binding 1.40054662654509 bayes_pls_golite062009
protein binding 1.21879977456466 bayes_pls_golite062009
transporter activity 1.21549336905926 bayes_pls_golite062009
tubulin binding 1.10875870970504 bayes_pls_golite062009
microtubule binding 1.03769395387791 bayes_pls_golite062009
substrate-specific transporter activity 0.734793983890004 bayes_pls_golite062009
nucleic acid binding 0.624115832843391 bayes_pls_golite062009
hydrolase activity 0.36638536879917 bayes_pls_golite062009
transcription repressor activity 0.328276176504109 bayes_pls_golite062009
transcription regulator activity 0.282387003961579 bayes_pls_golite062009
dynein binding 0.180120691665679 bayes_pls_golite062009
structural molecule activity 0.0588151480189092 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.00585398682921312 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [479-992] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HIDKTTPEYY LISSNDAIRV QELSLKDHFD WFMERKQYYK AWKIGKYVIG SEERFSIGLK  60
   61 FLNSLVTKKD WGTLVDHLNI IFEETLNSLD SNSYDVTQNV LKEWADIIEI LITSGNIVEI 120
  121 APLIPKKPAL RKSVYDDVLH YFLANDMINK FHEYITKWDL KLFSVEDFEE ELETRIEAAS 180
  181 EPTASSKEEG SNITYRTELV HLYLKENKYT KAIPHLLKAK DLRALTIIKI QNLLPQYLDQ 240
  241 IVDIILLPYK GEISHISKLS IFEIQTIFNK PIDLLFENRH TISVARIYEI FEHDCPKSFK 300
  301 KILFCYLIKF LDTDDSFMIS PYENQLIELY SEYDRQSLLP FLQKHNNYNV ESAIEVCSSK 360
  361 LGLYNELIYL WGKIGETKKA LSLIIDELKN PQLAIDFVKN WGDSELWEFM INYSLDKPNF 420
  421 TKAILTCSDE TSEIYLKVIR GMSDDLQIDN LQDIIKHIVQ ENSLSLEVRD NILVIINDET 480
  481 KKFANEFLKI RSQGKLFQVD ESDIEINDDL NGVL

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 12.83
Match: 1b89A
Description: Clathrin heavy chain proximal leg segment
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein transporter activity 2.99345877012947 bayes_pls_golite062009
binding 2.53151481871847 bayes_pls_golite062009
transporter activity 2.3766833486706 bayes_pls_golite062009
substrate-specific transporter activity 2.12926593993985 bayes_pls_golite062009
cytoskeletal protein binding 1.67265990792668 bayes_pls_golite062009
protein binding 1.61131270705552 bayes_pls_golite062009
transmembrane transporter activity 1.2724388835449 bayes_pls_golite062009
protein transmembrane transporter activity 1.12112006227201 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.04982314606251 bayes_pls_golite062009
nucleic acid binding 1.0110931222658 bayes_pls_golite062009
actin binding 0.864076688656138 bayes_pls_golite062009
hydrolase activity 0.648465506487331 bayes_pls_golite062009
signal sequence binding 0.279693431859311 bayes_pls_golite062009
active transmembrane transporter activity 0.260663498540354 bayes_pls_golite062009
ion transmembrane transporter activity 0.256036243669218 bayes_pls_golite062009
structural molecule activity 0.244712400498315 bayes_pls_golite062009
nuclear localization sequence binding 0.241630311762028 bayes_pls_golite062009
RNA binding 0.235569865745441 bayes_pls_golite062009
primary active transmembrane transporter activity 0.234271600707329 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 0.225395946682209 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0.186601655036333 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 0.183072614802483 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 0.182751938544977 bayes_pls_golite062009
transcription regulator activity 0.111971004877048 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.109435859778099 bayes_pls_golite062009
clathrin binding 0.0923079381755934 bayes_pls_golite062009
pyrophosphatase activity 0.0728493557966827 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.0641324729536009 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.0615190129942244 bayes_pls_golite062009
cation transmembrane transporter activity 0.0475280280823402 bayes_pls_golite062009
signal transducer activity 0.0143632526449453 bayes_pls_golite062009
molecular transducer activity 0.0143632526449453 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle