YRC Public Data Repository - Protein Structure Prediction

Protein:	GLT1
Organism:	Saccharomyces cerevisiae
Length:	2145 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GLT1.

Description	E-value	Query Range	Subject Range
GLS2_ARATH, GLTB... - Ferredoxin-dependent glutamate synthase 2, chloroplastic OS=Arabidopsis thaliana GN=GLU2 PE=1 SV=1, ...	0.0	[31..1567]	[85..1611]
GLTB_PORPU - Ferredoxin-dependent glutamate synthase OS=Porphyra purpurea GN=gltB PE=3 SV=1	0.0	[23..1550]	[3..1520]
gi\|16974913, gi\|... - gi\|16974913\|pdb\|1EA0\|B Chain B, Alpha Subunit Of A. Brasilense Glutamate Synthase, gi\|16974912\|pdb\|1...	0.0	[54..1549]	[1..1461]
CE02372 - WBGene00012326 glutamate synthase status:Partially_confirmed TR:Q22275 protein_id:CAA90032.1	0.0	[43..2141]	[48..2207]
GLTB_MAIZE - Ferredoxin-dependent glutamate synthase, chloroplastic OS=Zea mays GN=GLSF PE=1 SV=1	0.0	[40..1565]	[84..1616]
gi\|4521156 - gi\|4521156\|dbj\|BAA75929.1\| glutamine 2-oxoglutarate aminotransferase large subunit [Corynebacterium ...	0.0	[40..1578]	[2..1510]
CG9674-PC, CG9674-PB - This gene is referred to in FlyBase by the symbol Dmel\CG9674 (CG9674, FBgn0036663). It is a protein...	0.0	[1183..2132]	[1..913]
GLTS_SYNY3 - Ferredoxin-dependent glutamate synthase 2 OS=Synechocystis sp. (strain ATCC 27184 / PCC 6803 / N-1) ... gi\|7431780 - pir\|\|S76781 glutamate synthase (ferredoxin) (EC 1.4.7.1) precursor - Synechocystis sp. (strain PCC 6... GLTS_SYNY3 - Ferredoxin-dependent glutamate synthase 2 OS=Synechocystis sp. (strain PCC 6803 / Kazusa) GN=gltS PE...	0.0	[50..1551]	[33..1536]
gi\|25284756 - pir\|\|F86785 glutamate synthase (NADPH) (EC 1.4.1.13) large chain [imported] - Lactococcus lactis sub... gi\|15673268, gi\|... - gi\|15673268\|ref\|NP_267442.1\| glutamate synthase large subunit [Lactococcus lactis subsp. lactis Il14...	0.0	[41..1582]	[10..1485]
gi\|115349180, gi... - gi\|16123701\|ref\|NP_407014.1\| glutamate synthase [NADPH] large chain precursor [Yersinia pestis CO92]... gi\|166961520, gi... - gi\|167420714\|ref\|ZP_02312467.1\| glutamate synthase, large subunit [Yersinia pestis biovar Orientalis... gi\|25284762 - pir\|\|AF0432 glutamate synthase (NADPH) (EC 1.4.1.13) large chain precursor [imported] - Yersinia pes... gi\|165914521, gi... - gi\|165937416\|ref\|ZP_02225979.1\| glutamate synthase, large subunit [Yersinia pestis biovar Orientalis... gi\|153997332, gi... - gi\|153997332\|ref\|ZP_02022432.1\| glutamate synthase [NADPH] large chain precursor [Yersinia pestis CA... gi\|165919889, gi... - gi\|165928115\|ref\|ZP_02223947.1\| glutamate synthase, large subunit [Yersinia pestis biovar Orientalis...	0.0	[26..1568]	[29..1537]

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Predicted Domain #1

Region A:
Residues: [1-499]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPVLKSDNFD PLEEAYEGGT IQNYNDEHHL HKSWANVIPD KRGLYDPDYE HDACGVGFVA  60
   61 NKHGEQSHKI VTDARYLLVN MTHRGAVSSD GNGDGAGILL GIPHEFMKRE FKLDLDLDIP 120
  121 EMGKYAVGNV FFKKNEKNNK KNLIKCQKIF EDLAASFNLS VLGWRNVPVD STILGDVALS 180
  181 REPTILQPLL VPLYDEKQPE FNETKFRTQL YLLRKEASLQ IGLENWFYVC SLNNTTIVYK 240
  241 GQLTPAQVYN YYPDLTNAHF KSHMALVHSR FSTNTFPSWD RAQPLRWLAH NGEINTLRGN 300
  301 KNWMRSREGV MNSATFKDEL DKLYPIIEEG GSDSAALDNV LELLTINGTL SLPEAVMMMV 360
  361 PEAYHKDMDS DLKAWYDWAA CLMEPWDGPA LLTFTDGRYC GAILDRNGLR PCRYYITSDD 420
  421 RVICASEVGV IPIENSLVVQ KGKLKPGDLF LVDTQLGEMV DTKKLKSQIS KRQDFKSWLS 480
  481 KVIKLDDLLS KTANLVPKE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	11000.0
Match:	1llwA_
Description:	Alpha subunit of glutamate synthase, C-terminal domain; Alpha subunit of glutamate synthase, central and FMN domains; Alpha subunit of glutamate synthase, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
glutamate synthase activity	10.2123323896554	bayes_pls_golite062009
glutamate synthase activity, NADH or NADPH as acceptor	9.64220719720108	bayes_pls_golite062009
glutamate synthase (NADPH) activity	7.71666213946687	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	3.97793872368585	bayes_pls_golite062009
oxidoreductase activity	3.55520438339582	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors	1.75223963289059	bayes_pls_golite062009
catalytic activity	1.19663085909195	bayes_pls_golite062009
nucleic acid binding	1.07596988808091	bayes_pls_golite062009
endopeptidase activity	1.05931638234802	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	0.821264875808897	bayes_pls_golite062009
peptidase activity	0.755649562279406	bayes_pls_golite062009
binding	0.752066499785082	bayes_pls_golite062009
glutamate synthase (NADH) activity	0.589012306271491	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors	0.391558094818592	bayes_pls_golite062009
transferase activity, transferring acyl groups	0.181206025480438	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [500-856]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FISQDSLSLK VQSDPRLLAN GYTFEQVTFL LTPMALTGKE ALGSMGNDAP LACLNENPVL  60
   61 LYDYFRQLFA QVTNPPIDPI REANVMSLEC YVGPQGNLLE MHSSQCDRLL LKSPILHWNE 120
  121 FQALKNIEAA YPSWSVAEID ITFDKSEGLL GYTDTIDKIT KLASEAIDDG KKILIITDRK 180
  181 MGANRVSISS LIAISCIHHH LIRNKQRSQV ALILETGEAR EIHHFCVLLG YGCDGVYPYL 240
  241 AMETLVRMNR EGLLRNVNND NDTLEEGQIL ENYKHAIDAG ILKVMSKMGI STLASYKGAQ 300
  301 IFEALGLDNS IVDLCFTGTS SRIRGVTFEY LAQDAFSLHE RGYPSRQTIS KSVNLPE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	11000.0
Match:	1llwA_
Description:	Alpha subunit of glutamate synthase, C-terminal domain; Alpha subunit of glutamate synthase, central and FMN domains; Alpha subunit of glutamate synthase, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
glutamate synthase activity	8.25305391467034	bayes_pls_golite062009
glutamate synthase activity, NADH or NADPH as acceptor	8.23578981764913	bayes_pls_golite062009
glutamate synthase (NADPH) activity	6.79992270958953	bayes_pls_golite062009
oxidoreductase activity	3.19495080984613	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	2.59457345868059	bayes_pls_golite062009
succinate dehydrogenase activity	1.80846474206463	bayes_pls_golite062009
catalytic activity	1.56773888754354	bayes_pls_golite062009
binding	0.993436593091194	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	0.704326257168965	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor	0.242456601435627	bayes_pls_golite062009
succinate dehydrogenase (ubiquinone) activity	0.228954938673819	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor	0.228954938673819	bayes_pls_golite062009
protein binding	0.116927178396589	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [857-1292]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGEYHFRDGG YKHVNEPTAI ASLQDTVRNK NDVSWQLYVK KEMEAIRDCT LRGLLELDFE  60
   61 NSVSIPLEQV EPWTEIARRF ASGAMSYGSI SMEAHSTLAI AMNRLGAKSN CGEGGEDAER 120
  121 SAVQENGDTM RSAIKQVASA RFGVTSYYLS DADEIQIKIA QGAKPGEGGE LPAHKVSKDI 180
  181 AKTRHSTPNV GLISPPPHHD IYSIEDLKQL IYDLKCANPR AGISVKLVSE VGVGIVASGV 240
  241 AKAKADHILV SGHDGGTGAA RWTSVKYAGL PWELGLAETH QTLVLNDLRR NVVVQTDGQL 300
  301 RTGFDIAVAV LLGAESFTLA TVPLIAMGCV MLRRCHLNSC AVGIATQDPY LRSKFKGQPE 360
  361 HVINFFYYLI QDLRQIMAKL GFRTIDEMVG HSEKLKKRDD VNAKAINIDL SPILTPAHVI 420
  421 RPGVPTKFTK KQDHKL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	11000.0
Match:	1llwA_
Description:	Alpha subunit of glutamate synthase, C-terminal domain; Alpha subunit of glutamate synthase, central and FMN domains; Alpha subunit of glutamate synthase, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [1293-1608]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HTRLDNKLID EAEVTLDRGL PVNIDASIIN TDRALGSTLS YRVSKKFGED GLPKDTVVVN  60
   61 IEGSAGQSFG AFLASGITFI LNGDANDYVG KGLSGGIIVI KPPKDSKFKS DENVIVGNTC 120
  121 FYGATSGTAF ISGSAGERFG VRNSGATIVV ERIKGNNAFE YMTGGRAIVL SQMESLNAFS 180
  181 GATGGIAYCL TSDYDDFVGK INKDTVELES LCDPVEIAFV KNLIQEHWNY TQSDLAARIL 240
  241 GNFNHYLKDF VKVIPTDYKK VLLKEKAEAA KAKAKATSEY LKKFRSNQEV DDEVNTLLIA 300
  301 NQKAKEQEKK KSITIS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	11000.0
Match:	1llwA_
Description:	Alpha subunit of glutamate synthase, C-terminal domain; Alpha subunit of glutamate synthase, central and FMN domains; Alpha subunit of glutamate synthase, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [1609-2145]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKATLKEPKV VDLEDAVPDS KQLEKNSERI EKTRGFMIHK RRHETHRDPR TRVNDWKEFT  60
   61 NPITKKDAKY QTARCMDCGT PFCLSDTGCP LSNIIPKFNE LLFKNQWKLA LDKLLETNNF 120
  121 PEFTGRVCPA PCEGACTLGI IEDPVGIKSV ERIIIDNAFK EGWIKPCPPS TRTGFTVGVI 180
  181 GSGPAGLACA DMLNRAGHTV TVYERSDRCG GLLMYGIPNM KLDKAIVQRR IDLLSAEGID 240
  241 FVTNTEIGKT ISMDELKNKH NAVVYAIGST IPRDLPIKGR ELKNIDFAMQ LLESNTKALL 300
  301 NKDLEIIREK IQGKKVIVVG GGDTGNDCLG TSVRHGAASV LNFELLPEPP VERAKDNPWP 360
  361 QWPRVMRVDY GHAEVKEHYG RDPREYCILS KEFIGNDEGE VTAIRTVRVE WKKSQSGVWQ 420
  421 MVEIPNSEEI FEADIILLSM GFVGPELING NDNEVKKTRR GTIATLDDSS YSIDGGKTFA 480
  481 CGDCRRGQSL IVWAIQEGRK CAASVDKFLM DGTTYLPSNG GIVQRDYKLL KELASQV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	259.9897
Match:	1gt8A_
Description:	Dihydropyrimidine dehydrogenase, N-terminal domain; Dihydropyrimidine dehydrogenase, domain 4; Dihydropyrimidine dehydrogenase, domain 3; Dihydropyrimidine dehydrogenase, domain 2; Dihydropyrimidine dehydrogenase, C-terminal domain
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: