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View Structure Prediction Details

Protein: COP1
Organism: Saccharomyces cerevisiae
Length: 1201 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for COP1.

Description E-value Query
Range		 Subject
Range
COPA2_ORYSJ - Coatomer subunit alpha-2 OS=Oryza sativa subsp. japonica GN=Os03g0711500 PE=2 SV=1
gi|125545472 - gi|125545472|gb|EAY91611.1| hypothetical protein OsI_13245 [Oryza sativa Indica Group]
 0.0 [3..1197] [1..1210]
gi|3676167 - gi|3676167|emb|CAA09492.1| coatomer alpha subunit [Drosophila melanogaster]
 0.0 [3..1199] [1..1228]
gi|663088, gi|633648 - gi|663088|emb|CAA86588.1| Ret1p = alpha-COP = alpha subunit of the coatomer complex (COPI) [Saccharo...
 0.0 [1..1201] [1..1201]
COPA1_ARATH - Coatomer subunit alpha-1 OS=Arabidopsis thaliana GN=At1g62020 PE=2 SV=2
 0.0 [3..1197] [1..1208]
CE29136 - coatomer, alpha chain status:Confirmed UniProt:Q9N4H7 protein_id:AAF36010.2
 0.0 [1..1199] [1..1227]
gi|13445656 - gi|13445656|gb|AAK26326.1|AF339501_1 alpha-COP-like protein [Pichia angusta]
 0.0 [1..1199] [1..1204]
gi|3170523 - gi|3170523|gb|AAC18088.1| coatomer alpha subunit [Emericella nidulans]
 0.0 [3..1201] [1..1201]
gi|1237029 - gi|1237029|emb|CAA65543.1| alpha-cop protein [Bos primigenius]
COPA_BOVIN - Coatomer subunit alpha OS=Bos taurus GN=COPA PE=1 SV=1
 0.0 [3..1199] [1..1218]

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Predicted Domain #1
Region A:
Residues: [1-324] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKMLTKFESK STRAKGIAFH PSRPWVLVAL FSSTIQLWDY RMGTLLHRFE DHEGPVRGLD  60
   61 FHPTQPIFVS AGDDYTIKVW SLDTNKCLYT LTGHLDYVRT VFFHRELPWI ISASDDQTIR 120
  121 IWNWQNRKEI ACLTGHNHFV MCAQFHPTDD LIVSASLDET IRIWDISGLR KRHSAPGTSS 180
  181 FEEQMSAQQN LLDGSLGDCV VKFILEGHTR GVNWASFHPT LPLIVSGSDD RQVKLWRMSA 240
  241 TKAWEVDTCR GHTNNVDSVI FHPHQNLIIS VGEDKTLRVW DLDKRTPVKQ FKRENDRFWL 300
  301 IAAHPHINLF GAAHDSGIMV FKLD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 217.211549
Match: 1erjA_
Description: Tup1, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
structural molecule activity 5.05435272846365 bayes_pls_golite062009
histone methyltransferase activity (H3-K4 specific) 4.71992275913384 bayes_pls_golite062009
4.71945350582521 bayes_pls_golite062009
myosin heavy chain kinase activity 4.33124151198369 bayes_pls_golite062009
actin binding 3.86142918698875 bayes_pls_golite062009
acetyltransferase activity 3.85374902981345 bayes_pls_golite062009
RNA binding 3.77273677738815 bayes_pls_golite062009
myosin II binding 3.56132510021228 bayes_pls_golite062009
acyltransferase activity 3.35098520158193 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 3.31760161664239 bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups 3.31615347567536 bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity 3.25521258308263 bayes_pls_golite062009
transferase activity, transferring acyl groups 3.14917998298348 bayes_pls_golite062009
cytoskeletal protein binding 3.1056443224755 bayes_pls_golite062009
tubulin binding 2.76945430061825 bayes_pls_golite062009
microtubule binding 2.72684103222924 bayes_pls_golite062009
dynein binding 2.54821997913979 bayes_pls_golite062009
binding 2.42570478946173 bayes_pls_golite062009
snoRNA binding 2.27164613239345 bayes_pls_golite062009
protein binding 2.26925404328312 bayes_pls_golite062009
transcription regulator activity 2.10348788067437 bayes_pls_golite062009
actin filament binding 2.0735069176589 bayes_pls_golite062009
transcription repressor activity 2.03485691549401 bayes_pls_golite062009
nucleic acid binding 2.00420268007946 bayes_pls_golite062009
histone methyltransferase activity 1.85632145559025 bayes_pls_golite062009
dynactin binding 1.85146647785657 bayes_pls_golite062009
DNA binding 1.53482914288832 bayes_pls_golite062009
protein methyltransferase activity 1.35170368882651 bayes_pls_golite062009
transporter activity 1.21549336905926 bayes_pls_golite062009
transcription corepressor activity 1.2107661925348 bayes_pls_golite062009
histone-lysine N-methyltransferase activity 1.15313682561559 bayes_pls_golite062009
lysine N-methyltransferase activity 1.15313682561559 bayes_pls_golite062009
protein-lysine N-methyltransferase activity 1.15313682561559 bayes_pls_golite062009
receptor binding 1.10903984294711 bayes_pls_golite062009
mRNA binding 1.05053985350578 bayes_pls_golite062009
microtubule plus-end binding 1.01166033978052 bayes_pls_golite062009
myosin binding 0.989691178611801 bayes_pls_golite062009
receptor activity 0.973153886219821 bayes_pls_golite062009
protein transporter activity 0.964340340346761 bayes_pls_golite062009
transcription factor activity 0.897833210520351 bayes_pls_golite062009
kinase activity 0.807669232329985 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.805273887494167 bayes_pls_golite062009
molecular transducer activity 0.762533049716683 bayes_pls_golite062009
signal transducer activity 0.762533049716683 bayes_pls_golite062009
substrate-specific transporter activity 0.734793983890004 bayes_pls_golite062009
transcription activator activity 0.724420384084538 bayes_pls_golite062009
G-protein-coupled receptor binding 0.710786225826124 bayes_pls_golite062009
histone binding 0.685319917508843 bayes_pls_golite062009
transcription initiation factor activity 0.656824577987243 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.634547834947756 bayes_pls_golite062009
glycosaminoglycan binding 0.561837715670207 bayes_pls_golite062009
protein kinase activity 0.544118712921054 bayes_pls_golite062009
transcription factor binding 0.469377587704245 bayes_pls_golite062009
dynein intermediate chain binding 0.443846546939402 bayes_pls_golite062009
nucleotidyltransferase activity 0.28606552120995 bayes_pls_golite062009
transcription cofactor activity 0.245000508226811 bayes_pls_golite062009
structural constituent of cytoskeleton 0.118975415284669 bayes_pls_golite062009
protein serine/threonine kinase activity 0.0803897416817422 bayes_pls_golite062009
heparin binding 0.0276138170689455 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.00585398682921312 bayes_pls_golite062009
N-methyltransferase activity 0.00335766408304172 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [325-443] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RERPCSFIHQ NQLFFVNAEK QIQSFNFQKR VASLPYASLK GIGQPWDAFR SISYNPSQHS  60
   61 VLVNEANGKF ALVILPKQPV GAVEPTSVTQ DTGNFATFVG RNRFVVYNKN TESVEVRSL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 31.69897
Match: 1gxrA_
Description: Groucho/tle1, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.90408871052739 bayes_pls_golite062009
protein binding 1.47118967208188 bayes_pls_golite062009
catalytic activity 0.233388920718075 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [444-646] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ENKVTRNIKV EETVRTIVAA GPGSVLVIHP REVILYDVQQ GKKVSQLAVK NVKYVSWSLD  60
   61 GQYVALMSKH TITLATKKLE LINSMHETIR IKSAAWDETG VLIYSTLNHI RYSLLNGDRG 120
  121 IIKTLEKTLY ITKVQGKLVY CLNREGEIEI LTIDPTEYRF KKALVNKNFP EVLRLIKDSN 180
  181 LVGQNIISYL QKSGYPEIAL QFV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [647-792] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QDPHIRFDLA LEYGNLDVAL DEAKKLNDSS TWERLIQEAL AQGNASLAEM IYQTQHSFDK  60
   61 LSFLYLVTGD VNKLSKMQNI AQTREDFGSM LLNTFYNNST KERSSIFAEG GSLPLAYAVA 120
  121 KANGDEAAAS AFLEQAEVDE QDVTLP

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 9.91
Match: 1b89A
Description: Clathrin heavy chain proximal leg segment
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [793-980] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DQMDASNFVQ RPVISKPLEK WPLKEAELSY FEKAVLGQID DLTIDDETPA VNTTQEQEEP  60
   61 LGEENFNDED IGEDEGAWDL GDEDLDVGEE LPEEVEQGEI TSPAQEVETA IWIKNSKLPA 120
  121 VLVAAGAFDA AVQALSKQVG VVKLEPLKKY FTNIYEGCRT YIPSTPCELP AQLGYVRAYD 180
  181 DTVSEDQI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [981-1088] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPYVPGLDVV NEKMNEGYKN FKLNKPDIAI ECFREAIYRI TLLMVDDAED EKLAHKILET  60
   61 AREYILGLSI ELERRSLKEG NTVRMLELAA YFTKAKLSPI HRTNALQV

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.21
Match: 1elrA
Description: Hop
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [1089-1140] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AMSQHFKHKN FLQASYFAGE FLKIISSGPR AEQARKIKNK ADSMASDAIP ID

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.21
Match: 1elrA
Description: Hop
Matching Structure (courtesy of the PDB):

Predicted Domain #8
Region A:
Residues: [1141-1201] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FDPYAKFDIC AATYKPIYED TPSVSDPLTG SKYVITEKDK IDRIAMISKI GAPASGLRIR  60
   61 V

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle