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View Structure Prediction Details

Protein: SHP1
Organism: Saccharomyces cerevisiae
Length: 423 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SHP1.

Description E-value Query
Range		 Subject
Range
SHP1 - UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and...
gi|151946338 - gi|151946338|gb|EDN64560.1| suppressor of high-copy pp1 [Saccharomyces cerevisiae YJM789]
UBX1_YEAST - UBX domain-containing protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SHP1 PE=...
 0.0 [1..423] [1..423]
NSF1C_MOUSE - NSFL1 cofactor p47 OS=Mus musculus GN=Nsfl1c PE=1 SV=1
 2.0E-90 [1..421] [1..368]
NSF1C_RAT - NSFL1 cofactor p47 OS=Rattus norvegicus GN=Nsfl1c PE=1 SV=1
 3.0E-90 [1..421] [1..368]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 5.0E-82 [3..413] [4..412]
gi|56203342, gi|... - gi|7022811|dbj|BAA91731.1| unnamed protein product [Homo sapiens], gi|56203342|emb|CAI22731.1| NSFL1...
gi|114680501 - gi|114680501|ref|XP_001153830.1| PREDICTED: p47 protein isoform 2 [Pan troglodytes]
 3.0E-79 [1..421] [1..337]
PUX5_ARATH - Plant UBX domain-containing protein 5 OS=Arabidopsis thaliana GN=PUX5 PE=1 SV=1
 7.0E-78 [3..422] [4..421]
gi|13123659 - gi|13123659|gb|AAK12936.1|AF323104_1 phosphatase-like protein Psc923 [Pisum sativum]
 3.0E-77 [2..421] [8..399]
gi|13123657 - gi|13123657|gb|AAK12935.1|AF323103_1 phosphatase-like protein Mtc923 [Medicago truncatula]
 6.0E-76 [8..421] [16..404]
UBX3_SCHPO - UBX domain-containing protein 3 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ubx3 PE=1 ...
ubx3 - UBX domain protein Ubx3
 2.0E-64 [5..421] [3..408]

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Predicted Domain #1
Region A:
Residues: [1-121] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEIPDETIQ QFMALTNVSH NIAVQYLSEF GDLNEALNSY YASQTDDQKD RREEAHWNRQ  60
   61 QEKALKQEAF STNSSNKAIN TEHVGGLCPK PGSSQGSNEY LKRKGSTSPE PTKGSSRSGS 120
  121 G

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score		 SCOP
Match		 SCOP Description
View Download 0.205 f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.205 f.1.4 Bcl-2 inhibitors of programmed cell death

Predicted Domain #2
Region A:
Residues: [122-340] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NNSRFMSFSD MVRGQADDDD EDQPRNTFAG GETSGLEVTD PSDPNSLLKD LLEKARRGGQ  60
   61 MGAENGFRDD EDHEMGANRF TGRGFRLGST IDAADEVVED NTSQSQRRPE KVTREITFWK 120
  121 EGFQVADGPL YRYDDPANSF YLSELNQGRA PLKLLDVQFG QEVEVNVYKK LDESYKAPTR 180
  181 KLGGFSGQGQ RLGSPIPGES SPAEVPKNET PAAQEQPMP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term Confidence Notes
ubiquitin binding 3.08647023955532 bayes_pls_golite062009
small conjugating protein binding 2.81420954636829 bayes_pls_golite062009
binding 2.2560795328149 bayes_pls_golite062009
protein binding 1.0980671422772 bayes_pls_golite062009
nucleic acid binding 0.603841502857006 bayes_pls_golite062009
hydrolase activity 0.356947688028291 bayes_pls_golite062009
catalytic activity 0.25774924710417 bayes_pls_golite062009
DNA binding 0.227398235412559 bayes_pls_golite062009
transcription regulator activity 0.194425568150525 bayes_pls_golite062009
peptidase activity 0.0141774634963068 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [341-423] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DNEPKQGDTS IQIRYANGKR EVLHCNSTDT VKFLYEHVTS NANTDPSRNF TLNYAFPIKP  60
   61 ISNDETTLKD ADLLNSVVVQ RWA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 77.071898
Match: 1jruA_
Description: p47
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [313-423] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LGSPIPGESS PAEVPKNETP AAQEQPMPDN EPKQGDTSIQ IRYANGKREV LHCNSTDTVK  60
   61 FLYEHVTSNA NTDPSRNFTL NYAFPIKPIS NDETTLKDAD LLNSVVVQRW A

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 34.221849
Match: 1s3sG
Description: Crystal structure of AAA ATPase p97/VCP ND1 in complex with p47 C
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.63877637096497 bayes_pls_golite062009
protein binding 1.89134588490127 bayes_pls_golite062009
small conjugating protein ligase activity 1.83465130904364 bayes_pls_golite062009
ubiquitin-protein ligase activity 1.16468510691469 bayes_pls_golite062009
acid-amino acid ligase activity 0.919595189902044 bayes_pls_golite062009
nucleic acid binding 0.383121378043805 bayes_pls_golite062009
hydrolase activity 0.247201449341942 bayes_pls_golite062009
DNA binding 0.0840213088061073 bayes_pls_golite062009
transcription regulator activity 0.0485636215870291 bayes_pls_golite062009
cytoskeletal protein binding 0.00343080662821671 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle