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View Structure Prediction Details

Protein: PEP1
Organism: Saccharomyces cerevisiae
Length: 1579 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PEP1.

Description E-value Query
Range
Subject
Range
VTH2 - Putative membrane glycoprotein with strong similarity to Vth1p and Pep1p/Vps10p, may be involved in ...
VTH2_YEAST - VPS10 homolog 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=VTH2 PE=1 SV=1
0.0 [1..1579] [1..1549]
VPS10_SCHPO - Vacuolar protein sorting/targeting protein 10 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843)...
pep1 - sorting receptor for CPY
0.0 [7..1441] [14..1406]
gi|18032275 - gi|18032275|gb|AAL56667.1|AF284756_1 VPS10 domain receptor SorCS [Homo sapiens]
0.0 [723..1381] [182..795]
SORC1_MOUSE - VPS10 domain-containing receptor SorCS1 OS=Mus musculus GN=Sorcs1 PE=1 SV=1
0.0 [723..1381] [182..794]

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Predicted Domain #1
Region A:
Residues: [1-217]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MILLHFVYSL WALLLIPLTN AEEFTPKVTK TIAQDSFDIL SFDDSNTLIR KQDTSVTISF  60
   61 DDGETWEKVE GIEGEITWIY IDPFNRHDRA VATAMNGSYL YITNDQGKSW ERITLPDSGE 120
  121 SISPRECYIE THPLNKNYFL AKCNYCEKTE VNNDNEENSG DEEGQFEIFN ITRCTDKVFA 180
  181 SNDGGKSFSE IKSSLERNEN SPISISDCGF AKTSKDS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [218-291]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLESSDTSII CLFQNMQLIM DEFSSPYTES KLVLTTDWGK SLKEFDQFKD KVVNGYRILK  60
   61 SHMVVLTQGD RYND

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
binding 1.66964148100475 bayes_pls_golite062009
protein binding 0.931624635835922 bayes_pls_golite062009
transporter activity 0.711149297585691 bayes_pls_golite062009
transmembrane transporter activity 0.517650155593165 bayes_pls_golite062009
substrate-specific transporter activity 0.276105437109391 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.113736784801445 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [292-594]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSMDVWVSN DLSNFKMAYM PTQLRHSMQG EIYEDAMGRI ILPMSRERSD QEEDKGIVSE  60
   61 ILISDSQGLK FSPIPWTANE VFGYINFYQP TYLKGTMIAS LYPLSRRRNR KGKAKGVKSK 120
  121 GVTKISVDNG LTWTMLKVVD PDNADSFDCD ITDFENCSLQ NMFYTREGST PTAGILMTTG 180
  181 IVGDGSVFDW GDQRTFISRD GGLTWKLAFD FPCLYAVGDY GNVIVAIPYN ADEDDDPQSE 240
  241 FYYSLDQGKT WTEYQLETTI YPNEVMNTTP DGSGAKFILN GFTLAHMDGT TNFIYAIDFS 300
  301 TAF

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [595-685]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDKTCEENDF EDWNLAEGKC VNGVKYKIRR RKQDAQCLVK KVFEDLQLFE TACDKCTEAD  60
   61 YECAFEFVRD ATGKCVPDYN LIVLSDVCDK T

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [686-1421]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKKTVPVKPL QLVKGDKCKK PMTVKSVDIS CEGVPKKGTN DKEIVVTENK FDFKIQFYQY  60
   61 FDTVTDESLL MINSRGEAYI SHDGGQTIKR FDSNGETIIE VVFNPYYNSS AYLFGSKGSI 120
  121 FSTHDRGYSF MTAKLPEARQ LGMPLDFNAK AQDTFIYYGG KNCESILSPE CHAVAYLTND 180
  181 GGETFTEMLD NAIHCEFAGS LFKYPSNEDM VMCQVKEKSS QTRSLVSSTD FFQDDKNTVF 240
  241 ENIIGYLSTG GYIIVAVPHE NNELRAYVTI DGTEFAEAKF PYDEDVGKQE AFTILESEKG 300
  301 SIFLHLATNL VPGRDFGNLL KSNSNGTSFV TLEHAVNRNT FGYVDFEKIQ GLEGIILTNI 360
  361 VSNSDKVAEN KEDKQLKTKI TFNEGSDWNF LKPPKRDSEG KKFSCSSKSL DECSLHLHGY 420
  421 TERKDIRDTY SSGSALGMMF GVGNVGPNLL PYKECSTFFT TDGGETWAEV KKTPHQWEYG 480
  481 DHGGILVLVP ENSETDSISY STDFGKTWKD YKFCADKVLV KDITTVPRDS ALRFLLFGEA 540
  541 ADIGGSSFRT YTIDFRNIFE RQCDFDITGK ESADYKYSPL GSKSNCLFGH QTEFLRKTDE 600
  601 NCFIGNIPLS EFSRNIKNCS CTRQDFECDY NFYKANDGTC KLVKGLSPAN AADVCKKEPD 660
  661 LIEYFESSGY RKIPLSTCEG GLKLDAPSSP HACPGKEKEF KEKYSVSAGP FAFIFISILL 720
  721 IIFFAAWFVY DRGIRR

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [1422-1579]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NGGFARFGEI RLGDDGLIEN NNTDRVVNNI VKSGFYVFSN IGSLLQHTKT NIAHAISKIR  60
   61 GRFGNRTGPS YSSLIHDQFL DEADDLLAGH DEDANDLSSF MDQGSNFEIE EDDVPTLEEE 120
  121 HTSYTDQPTT TDVPDTLPEG NEENIDRPDS TAPSNENQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle