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View Structure Prediction Details

Protein: CDC15
Organism: Saccharomyces cerevisiae
Length: 974 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CDC15.

Description E-value Query
Range
Subject
Range
gi|298025, gi|39... - gi|399197|sp|P27636.2|CDC15_YEAST RecName: Full=Cell division control protein 15, gi|298030|emb|CAA3...
0.0 [1..974] [1..974]
CIPKC_ARATH - CBL-interacting serine/threonine-protein kinase 12 OS=Arabidopsis thaliana GN=CIPK12 PE=1 SV=1
0.0 [4..376] [1..395]
MARK2_RAT - Serine/threonine-protein kinase MARK2 OS=Rattus norvegicus GN=Mark2 PE=1 SV=1
0.0 [2..410] [29..442]
gi|125524847 - gi|125524847|gb|EAY72961.1| hypothetical protein OsI_00833 [Oryza sativa Indica Group]
CIPK5_ORYSJ - CBL-interacting protein kinase 5 OS=Oryza sativa subsp. japonica GN=CIPK5 PE=2 SV=1
0.0 [24..418] [11..406]
gi|119594583, gi... - gi|86990439|ref|NP_004945.3| MAP/microtubule affinity-regulating kinase 2 isoform b [Homo sapiens], ...
0.0 [11..406] [6..405]
gi|213625117, gi... - gi|213625117|gb|AAI69869.1| SNF1-like protein AMPK [Xenopus laevis], gi|18478805|gb|AAL73336.1| SNF1...
0.0 [17..455] [19..463]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [11..406] [6..405]

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Predicted Domain #1
Region A:
Residues: [1-101]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSMADTDRV NLTPIQRASE KSVQYHLKQV IGRGSYGVVY KAINKHTDQV VAIKEVVYEN  60
   61 DEELNDIMAE ISLLKNLNHN NIVKYHGFIR KSYELYILLE Y

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 447.218487
Match: 1f3mC_
Description: pak1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphotransferase activity, alcohol group as acceptor 5.49988294224815 bayes_pls_golite062009
protein kinase activity 5.4586557943719 bayes_pls_golite062009
kinase activity 5.3287080791198 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.96052051118534 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
calmodulin-dependent protein kinase activity 4.31938467136214 bayes_pls_golite062009
transferase activity 3.97138602499442 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
protein binding 2.276111749106 bayes_pls_golite062009
tubulin binding 2.18641675163967 bayes_pls_golite062009
cytoskeletal protein binding 2.12615078788254 bayes_pls_golite062009
fibroblast growth factor receptor activity 2.07350687583102 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
microtubule binding 1.88110801192607 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
fibroblast growth factor binding 1.46046123990071 bayes_pls_golite062009
JUN kinase kinase kinase activity 1.41172362253967 bayes_pls_golite062009
protein tyrosine kinase activity 1.3898059094397 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.38496328649031 bayes_pls_golite062009
actin binding 1.33479685165255 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.32254739984688 bayes_pls_golite062009
gamma-tubulin binding 1.28511591054866 bayes_pls_golite062009
receptor signaling protein activity 1.27291233344322 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
fibroblast growth factor 1 binding 1.0383359654359 bayes_pls_golite062009
cyclin-dependent protein kinase activity 0.959360414036299 bayes_pls_golite062009
MAP kinase activity 0.81943579965027 bayes_pls_golite062009
structural constituent of cytoskeleton 0.612883428421652 bayes_pls_golite062009
transporter activity 0.595111702412257 bayes_pls_golite062009
insulin receptor substrate binding 0.57867852584301 bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity 0.48345772948903 bayes_pls_golite062009
enzyme binding 0.46284745266176 bayes_pls_golite062009
transmembrane transporter activity 0.41384976209545 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
MAP kinase kinase kinase activity 0.37115026509016 bayes_pls_golite062009
MAP kinase kinase activity 0.35402045013148 bayes_pls_golite062009
protein complex binding 0.343240719858581 bayes_pls_golite062009
structure-specific DNA binding 0.318153468064373 bayes_pls_golite062009
signal transducer activity 0.270054246024761 bayes_pls_golite062009
molecular transducer activity 0.270054246024761 bayes_pls_golite062009
actin filament binding 0.2403700250846 bayes_pls_golite062009
ubiquitin-protein ligase activity 0.114318824149111 bayes_pls_golite062009
substrate-specific transporter activity 0.0922946791401962 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.0556163711947139 bayes_pls_golite062009
transmembrane receptor activity 0.00652065412910241 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0040394359628233 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [102-347]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CANGSLRRLI SRSSTGLSEN ESKTYVTQTL LGLKYLHGEG VIHRDIKAAN ILLSADNTVK  60
   61 LADFGVSTIV NSSALTLAGT LNWMAPEILG NRGASTLSDI WSLGATVVEM LTKNPPYHNL 120
  121 TDANIYYAVE NDTYYPPSSF SEPLKDFLSK CFVKNMYKRP TADQLLKHVW INSTENVKVD 180
  181 KLNKFKEDFT DADYHWDADF QEEKLNISPS KFSLRAAPAP WAENNQELDL MPPTESQLLS 240
  241 QLKSSS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 447.218487
Match: 1f3mC_
Description: pak1
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [348-864]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPLTDLHVLF SVCSLENIAD TIIECLSRTT VDKRLITAFG SIFVYDTQHN HSRLRLKFIA  60
   61 MGGIPLIIKF EHLAKEFVID YPQTLIECGI MYPPNFASLK TPKYILELVY RFYDLTSTAF 120
  121 WCRWCFKHLD ISLLLNNIHE RRAQSILLKL SSYAPWSFEK ILPSLIDSKL KKKILISPQI 180
  181 TYVVFKSINY MITTNDDKIH KSAIPSSSSL PLSSSPTRNS PVNSVQSPSR SPVHSLMATR 240
  241 PSSPMRHKSI SNFPHLTISS KSRLLIELPE GFFTWLTSFF VDMAQIKDLS VLKYFTKLCY 300
  301 LTVHINSTFL NDLLDNDAFF AFIRNIDTII PFIDDAKTAA FIWKQITAIC VEMSLDMDQM 360
  361 SASLFSTAMN FIRKKNNTSI SGLEIILNCL HFTLRNVNDD VAPTVGSSES HSVFLIKVNN 420
  421 DAAIELPIDQ LVDLFYALND DDVNLSKLIS IFTKICSLPG FENLTINIIF HPNFYEKIVS 480
  481 FFDTYFNSLL IQIDLLKFIK LIFSKSLLKL YDYTGQP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [865-974]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DPIKQTEPNR RNKATVFKLR AILVQITEFL NNNWNNGCPK RNSNQVGGDS VLICQLCEDI  60
   61 RSLSKKGSLQ KVSSVTAAIG SSPTKDERSN LRSSKDKSDG FSVPITTFQT 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [758-871]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HSVFLIKVNN DAAIELPIDQ LVDLFYALND DDVNLSKLIS IFTKICSLPG FENLTINIIF  60
   61 HPNFYEKIVS FFDTYFNSLL IQIDLLKFIK LIFSKSLLKL YDYTGQPDPI KQTE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [872-974]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PNRRNKATVF KLRAILVQIT EFLNNNWNNG CPKRNSNQVG GDSVLICQLC EDIRSLSKKG  60
   61 SLQKVSSVTA AIGSSPTKDE RSNLRSSKDK SDGFSVPITT FQT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle