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View Structure Prediction Details

Protein: KIN3
Organism: Saccharomyces cerevisiae
Length: 435 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for KIN3.

Description E-value Query
Range
Subject
Range
KIN3 - Nonessential protein kinase with unknown cellular role
gi|190406646 - gi|190406646|gb|EDV09913.1| serine/threonine-protein kinase KIN3 [Saccharomyces cerevisiae RM11-1a]
gi|151941398 - gi|151941398|gb|EDN59769.1| serine/threonine protein kinase [Saccharomyces cerevisiae YJM789]
KIN3_YEAST - Serine/threonine-protein kinase KIN3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=KIN...
0.0 [1..435] [1..435]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [7..419] [22..405]
gi|7339534 - gi|7339534|emb|CAB82852.1| protein kinase MK6 [Mesembryanthemum crystallinum]
0.0 [7..419] [107..490]
gi|17381026, gi|... - gi|22331282|ref|NP_188973.2| protein kinase, putative [Arabidopsis thaliana], gi|20465361|gb|AAM2008...
0.0 [3..417] [98..486]
gi|125532353 - gi|125532353|gb|EAY78918.1| hypothetical protein OsI_34019 [Oryza sativa Indica Group]
gi|13129502, gi|... - gi|37535354|ref|NP_921979.1| putative protein kinase [Oryza sativa (japonica cultivar-group)], gi|31...
0.0 [1..420] [89..482]

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Predicted Domain #1
Region A:
Residues: [1-14]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHRRQFFQEY RSPQ

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [68-88]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QLIAECSILS QLKHENIVEF Y

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [105-369]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YCSRGDLSQM IKHYKQEHKY IPEKIVWGIL AQLLTALYKC HYGVELPTLT TIYDRMKPPV  60
   61 KGKNIVIHRD LKPGNIFLSY DDSDYNINEQ VDGHEEVNSN YYRDHRVNSG KRGSPMDYSQ 120
  121 VVVKLGDFGL AKSLETSIQF ATTYVGTPYY MSPEVLMDQP YSPLSDIWSL GCVIFEMCSL 180
  181 HPPFQAKNYL ELQTKIKNGK CDTVPEYYSR GLNAIIHSMI DVNLRTRPST FELLQDIQIR 240
  241 TARKSLQLER FERKLLDYEN ELTNI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 230.54902
Match: 1ctpE_
Description: cAMP-dependent PK, catalytic subunit
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphotransferase activity, alcohol group as acceptor 5.49988294224815 bayes_pls_golite062009
protein kinase activity 5.4586557943719 bayes_pls_golite062009
kinase activity 5.3287080791198 bayes_pls_golite062009
cyclic nucleotide-dependent protein kinase activity 4.97855712164511 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.96052051118534 bayes_pls_golite062009
cAMP-dependent protein kinase activity 4.66277812893755 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
transferase activity 3.97138602499442 bayes_pls_golite062009
protein tyrosine kinase activity 2.8153155526437 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
transmembrane receptor activity 2.59526003830791 bayes_pls_golite062009
transmembrane receptor protein kinase activity 2.54265774272269 bayes_pls_golite062009
molecular transducer activity 2.40586892801446 bayes_pls_golite062009
signal transducer activity 2.40586892801446 bayes_pls_golite062009
receptor activity 2.39311927684508 bayes_pls_golite062009
protein binding 2.276111749106 bayes_pls_golite062009
tubulin binding 2.18641675163967 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 2.16831387024372 bayes_pls_golite062009
cytoskeletal protein binding 2.12615078788254 bayes_pls_golite062009
receptor signaling protein activity 2.10379226653669 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
microtubule binding 1.88110801192607 bayes_pls_golite062009
acetylcholine receptor activator activity 1.83545227594542 bayes_pls_golite062009
phosphoinositide 3-kinase binding 1.82515074380651 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.81249386965144 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
insulin receptor substrate binding 1.62657794525303 bayes_pls_golite062009
transcription regulator activity 1.56748951434625 bayes_pls_golite062009
DNA binding 1.35333135345112 bayes_pls_golite062009
actin binding 1.33479685165255 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
nucleic acid binding 1.16049201286103 bayes_pls_golite062009
transporter activity 1.11833481501707 bayes_pls_golite062009
transcription factor activity 1.10928254946881 bayes_pls_golite062009
structural molecule activity 1.10436308210353 bayes_pls_golite062009
transmembrane transporter activity 0.97575992765505 bayes_pls_golite062009
cyclin-dependent protein kinase activity 0.959360414036299 bayes_pls_golite062009
growth factor binding 0.86076618871384 bayes_pls_golite062009
MAP kinase activity 0.81943579965027 bayes_pls_golite062009
structural constituent of cytoskeleton 0.612883428421652 bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity 0.48345772948903 bayes_pls_golite062009
enzyme binding 0.46284745266176 bayes_pls_golite062009
substrate-specific transporter activity 0.451090007290896 bayes_pls_golite062009
protein kinase C activity 0.41587987561486 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
MAP kinase kinase kinase activity 0.37115026509016 bayes_pls_golite062009
MAP kinase kinase activity 0.35402045013148 bayes_pls_golite062009
kinase binding 0.26752427107238 bayes_pls_golite062009
insulin receptor binding 0.266450215230107 bayes_pls_golite062009
actin filament binding 0.2403700250846 bayes_pls_golite062009
protein complex binding 0.239339759110451 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity 0.20643152368029 bayes_pls_golite062009
transforming growth factor beta receptor activity 0.20643152368029 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.205652638854091 bayes_pls_golite062009
ErbB-2 class receptor binding 0.182469382556979 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.0405961152540697 bayes_pls_golite062009
protein kinase binding 0.00674998152095019 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0040394359628233 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [15-67]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QQQGHPPRSE YQVLEEIGRG SFGSVRKVIH IPTKKLLVRK DIKYGHMNSK ERQ

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [89-104]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NWDFDEQKEV LYLYME

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [370-435]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKILEKQAIE YERELSQLKE QFTQAVEERA REVISGKKVG KVPESINGYY GKKFAKPAYH  60
   61 WQTRYR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 230.54902
Match: 1ctpE_
Description: cAMP-dependent PK, catalytic subunit
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle