YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|61362363, gi\|...
Organism:	synthetic construct
Length:	797 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|61362363, gi|....

Description	E-value	Query Range	Subject Range
gi\|30584215, gi\|... - gi\|60653943\|gb\|AAX29664.1\| tubulin beta 4 [synthetic construct], gi\|30584215\|gb\|AAP36356.1\| Homo sap...	0.0	[1..797]	[1..797]
TBB3_BOVIN - Tubulin beta-3 chain OS=Bos taurus GN=TUBB3 PE=1 SV=1 ENSMMUT000000391... - null, null TUBB4, TUBB3 - tubulin, beta 4, tubulin, beta 3 TBB3_MACFA - Tubulin beta-3 chain OS=Macaca fascicularis GN=TUBB3 PE=2 SV=1 gi\|57086939 - gi\|57086939\|ref\|XP_536745.1\| PREDICTED: similar to tubulin, beta 3 isoform 1 [Canis familiaris]	0.0	[348..797]	[1..450]
TBB3_RAT - Tubulin beta-3 chain OS=Rattus norvegicus GN=Tubb3 PE=1 SV=1 TBB3_MOUSE - Tubulin beta-3 chain OS=Mus musculus GN=Tubb3 PE=1 SV=1	0.0	[348..797]	[1..450]
gi\|73956775 - gi\|73956775\|ref\|XP_859971.1\| PREDICTED: similar to tubulin, beta 3 isoform 2 [Canis familiaris]	0.0	[348..797]	[1..453]
gi\|157132376, gi... - gi\|157132376\|ref\|XP_001656025.1\| tubulin beta chain [Aedes aegypti], gi\|108881720\|gb\|EAT45945.1\| tub...	0.0	[348..793]	[1..446]
gi\|91086093 - gi\|91086093\|ref\|XP_967267.1\| PREDICTED: similar to beta1-tubulin [Tribolium castaneum]	0.0	[348..793]	[1..446]
gi\|48095525 - gi\|48095525\|ref\|XP_392313.1\| PREDICTED: similar to -Tubulin at 56D CG9277-PB, isoform B [Apis mellif...	0.0	[348..793]	[1..446]

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Predicted Domain #1

Region A:
Residues: [1-339]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVQGSQRRL LGSLNSTPTA IPQLGLAANQ TGARCLEVSI SDGLFLSLGL VSLVENALVV  60
   61 ATIAKNRNLH SPMYCFICCL ALSDLLVSGS NVLETAVILL LEAGALVARA AVLQQLDNVI 120
  121 DVITCSSMLS SLCFLGAIAV DRYISIFYAL RYHSIVTLPR ARRAVAAIWV ASVVFSTLFI 180
  181 AYYDHVAVLL CLVVFFLAML VLMAVLYVHM LARACQHAQG IARLHKRQRP VHQGFGLKGA 240
  241 VTLTILLGIF FLCWGPFFLH LTLIVLCPEH PTCGCIFKNF NLFLALIICN AIIDPLIYAF 300
  301 HSQELRRTLK EVLTCSCSQD RALVSWDVKS LGGSVCQEL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	52.522879
Match:	1f88A
Description:	Rhodopsin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
G-protein coupled receptor activity	8.71814901383196	bayes_pls_golite062009
receptor activity	7.06055966221158	bayes_pls_golite062009
transmembrane receptor activity	7.01539599282724	bayes_pls_golite062009
peptide receptor activity, G-protein coupled	6.12541205240173	bayes_pls_golite062009
molecular transducer activity	6.05267963238754	bayes_pls_golite062009
signal transducer activity	6.05267963238754	bayes_pls_golite062009
peptide receptor activity	6.04856799440486	bayes_pls_golite062009
neuropeptide binding	5.46057090687513	bayes_pls_golite062009
neuropeptide receptor activity	5.46057090687513	bayes_pls_golite062009
neurotransmitter receptor activity	5.35616101960681	bayes_pls_golite062009
neurotransmitter binding	5.22191968259492	bayes_pls_golite062009
photoreceptor activity	4.93686830751267	bayes_pls_golite062009
peptide binding	4.8780653006611	bayes_pls_golite062009
G-protein coupled photoreceptor activity	4.79156570848004	bayes_pls_golite062009
G-protein coupled amine receptor activity	3.93706716877289	bayes_pls_golite062009
olfactory receptor activity	3.47550162115408	bayes_pls_golite062009
opioid receptor activity	3.22729840146067	bayes_pls_golite062009
binding	2.79468187106818	bayes_pls_golite062009
tachykinin receptor activity	2.4986802041908	bayes_pls_golite062009
cytoskeletal protein binding	2.17253122279743	bayes_pls_golite062009
growth hormone secretagogue receptor activity	2.12517933332362	bayes_pls_golite062009
transcription regulator activity	1.9083697316027	bayes_pls_golite062009
11-cis retinal binding	1.87079306077199	bayes_pls_golite062009
mu-opioid receptor activity	1.85643264850844	bayes_pls_golite062009
somatostatin receptor activity	1.6896410144458	bayes_pls_golite062009
protein-hormone receptor activity	1.64635966454507	bayes_pls_golite062009
protein binding	1.56689457520546	bayes_pls_golite062009
actin binding	1.53432028087227	bayes_pls_golite062009
adrenoceptor activity	1.41816467611311	bayes_pls_golite062009
transporter activity	1.29312621296064	bayes_pls_golite062009
amine binding	1.15102749202013	bayes_pls_golite062009
melatonin receptor activity	1.075988883638	bayes_pls_golite062009
transmembrane transporter activity	1.07260547988411	bayes_pls_golite062009
norepinephrine binding	0.91306142065396	bayes_pls_golite062009
beta2-adrenergic receptor activity	0.91306142065396	bayes_pls_golite062009
beta-adrenergic receptor activity	0.91306142065396	bayes_pls_golite062009
galanin receptor activity	0.89794875509843	bayes_pls_golite062009
substrate-specific transporter activity	0.803790338332977	bayes_pls_golite062009
neuropeptide Y receptor activity	0.787828595997633	bayes_pls_golite062009
melanin-concentrating hormone receptor activity	0.68517896633151	bayes_pls_golite062009
allatostatin receptor activity	0.57306858576999	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.54988113115303	bayes_pls_golite062009
growth hormone-releasing hormone receptor activity	0.54640132962575	bayes_pls_golite062009
serotonin receptor activity	0.50108422883067	bayes_pls_golite062009
epinephrine binding	0.461468741834171	bayes_pls_golite062009
vitamin binding	0.4299798536797	bayes_pls_golite062009
pancreatic polypeptide receptor activity	0.344419397658879	bayes_pls_golite062009
peptide YY receptor activity	0.341945374420772	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.320380030702672	bayes_pls_golite062009
transferase activity	0.317278477863072	bayes_pls_golite062009
kinase activity	0.295597002136203	bayes_pls_golite062009
ion transmembrane transporter activity	0.249956975851186	bayes_pls_golite062009
retinal binding	0.23973229872245	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.221400419532118	bayes_pls_golite062009
gated channel activity	0.121740107050698	bayes_pls_golite062009
protein kinase activity	0.093744276691932	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [340-797]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPQQPQEKGL CDQKASSTAL QRLLQKEFWE VISDEHGIDP SGNYVGDSDL QLERISVYYN  60
   61 EASSHKYVPR AILVDLEPGT MDSVRSGAFG HLFRPDNFIF GQSGAGNNWA KGHYTEGAEL 120
  121 VDSVLDVVRK ECENCDCLQG FQLTHSLGGG TGSGMGTLLI SKVREEYPDR IMNTFSVVPS 180
  181 PKVSDTVVEP YNATLSIHQL VENTDETYCI DNEALYDICF RTLKLATPTY GDLNHLVSAT 240
  241 MSGVTTSLRF PGQLNADLRK LAVNMVPFPR LHFFMPGFAP LTARGSQQYR ALTVPELTQQ 300
  301 MFDAKNMMAA CDPRHGRYLT VATVFRGRMS MKEVDEQMLA IQSKNSSYFV EWIPNNVKVA 360
  361 VCDIPPRGLK MSSTFIGNST AIQELFKRIS EQFTAMFRRK AFLHWYTGEG MDEMEFTEAE 420
  421 SNMNDLVSEY QQYQDATAEE EGEMYEDDEE ESEAQGPK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	170.0
Match:	1ffxB
Description:	Tubulin:stathmin-like domain complex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
structural constituent of cytoskeleton	4.04224160177678	bayes_pls_golite062009
structural molecule activity	3.32779015200848	bayes_pls_golite062009
tubulin binding	2.4432045213385	bayes_pls_golite062009
cytoskeletal protein binding	2.24606230377981	bayes_pls_golite062009
binding	2.00508289492248	bayes_pls_golite062009
GTPase activity	1.87512665946067	bayes_pls_golite062009
nucleoside-triphosphatase activity	1.77500173070686	bayes_pls_golite062009
pyrophosphatase activity	1.7017047947554	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	1.68267378160702	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	1.68038087466376	bayes_pls_golite062009
protein binding	1.60795853516357	bayes_pls_golite062009
MHC class I protein binding	1.46574865275013	bayes_pls_golite062009
gamma-tubulin binding	1.02742779831447	bayes_pls_golite062009
hydrolase activity	0.502038132260603	bayes_pls_golite062009
receptor binding	0.00945891657658993	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: