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View Structure Prediction Details

Protein: gi|71911696, gi|...
Organism: Drosophila melanogaster
Length: 1196 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|71911696, gi|....

Description E-value Query
Range
Subject
Range
gi|114676418 - gi|114676418|ref|XP_524454.2| PREDICTED: zinc finger protein 91 [Pan troglodytes]
737.0 [0..204] [1190..324]

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Predicted Domain #1
Region A:
Residues: [1-183]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAQPQLLQIK LSRFDAQPWG FRLQGGTDFA QPLLVQKVNA GSLSEQAGLQ PGDAVVKIND  60
   61 VDVFNLRHKD AQDIVVRSGN NFVITVQRGG STWRPHVTPT GNVPQPNSPY LQTVTKTSLA 120
  121 HKQQDSQHIG CGYNNAARPF SNGGDGGVKS IVNKQYNTPV GIYSDESIAE TLSAQAEVLA 180
  181 GGV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 24.522879
Match: 1v5lA
Description: Solution structure of PDZ domain of mouse Alpha-actinin-2 associated LIM protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
structural constituent of muscle 3.94885944537237 bayes_pls_golite062009
actin binding 3.71885072001885 bayes_pls_golite062009
actinin binding 3.61513078757793 bayes_pls_golite062009
cytoskeletal protein binding 3.60106431937699 bayes_pls_golite062009
binding 3.2595117613307 bayes_pls_golite062009
protein binding 2.35875654816667 bayes_pls_golite062009
transcription regulator activity 2.16834620509051 bayes_pls_golite062009
actin filament binding 1.91421788587359 bayes_pls_golite062009
myosin binding 1.34447751574529 bayes_pls_golite062009
alpha-actinin binding 0.81785989473612 bayes_pls_golite062009
transporter activity 0.782216866213126 bayes_pls_golite062009
structural molecule activity 0.745651480925433 bayes_pls_golite062009
transmembrane transporter activity 0.699604120098573 bayes_pls_golite062009
PDZ domain binding 0.53069705861477 bayes_pls_golite062009
substrate-specific transporter activity 0.434921764966531 bayes_pls_golite062009
protein domain specific binding 0.30840185305841 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.250590541549843 bayes_pls_golite062009
molecular transducer activity 0.211809989510755 bayes_pls_golite062009
signal transducer activity 0.211809989510755 bayes_pls_golite062009
structural constituent of cytoskeleton 0.182094987832726 bayes_pls_golite062009
transcription coactivator activity 0.171693460058476 bayes_pls_golite062009
transcription activator activity 0.0433431329070377 bayes_pls_golite062009
transcription factor binding 0.0283953080227368 bayes_pls_golite062009
receptor binding 0.00333430733556384 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [184-267]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LGVNFKKNEK EYQGDRSEVL KFLREEETGQ STPAFGNSHY EHDAPQQLQQ PQQQYNQHQQ  60
   61 HYHQQQQQQQ SSTTRHVSAP VNSP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [268-355]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPPSTGGLPT GQNICTECER LITGVFVRIK DKNLHVECFK CATCGTSLKN QGYYNFNNKL  60
   61 YCDIHAKQAA INNPPTGTEG YVPVPIKP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.0
Match: 1x64A
Description: Solution structure of the LIM domain of alpha-actinin-2 associated LIM protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.00967542385368 bayes_pls_golite062009
DNA binding 3.60745514727532 bayes_pls_golite062009
actin binding 3.16886380675327 bayes_pls_golite062009
nucleic acid binding 3.16757861573985 bayes_pls_golite062009
binding 2.96409924710655 bayes_pls_golite062009
transcription factor activity 2.90769972671972 bayes_pls_golite062009
cytoskeletal protein binding 2.31497455728997 bayes_pls_golite062009
actin filament binding 1.88919389919607 bayes_pls_golite062009
sequence-specific DNA binding 1.62841402245495 bayes_pls_golite062009
transcription activator activity 1.62405765585032 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.59407701118798 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.50210964370113 bayes_pls_golite062009
ligand-dependent nuclear receptor activity 1.49515149729803 bayes_pls_golite062009
protein binding 1.39455913713025 bayes_pls_golite062009
transcription factor binding 1.38523780690867 bayes_pls_golite062009
receptor activity 1.2947757480478 bayes_pls_golite062009
structural constituent of ribosome 1.14370842685155 bayes_pls_golite062009
structural molecule activity 1.03433454627943 bayes_pls_golite062009
molecular transducer activity 1.02134399426658 bayes_pls_golite062009
signal transducer activity 1.02134399426658 bayes_pls_golite062009
transporter activity 0.883869495141753 bayes_pls_golite062009
transmembrane transporter activity 0.69816175939074 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.68270103300828 bayes_pls_golite062009
transcription coactivator activity 0.61572149323953 bayes_pls_golite062009
transcription cofactor activity 0.58115018700114 bayes_pls_golite062009
substrate-specific transporter activity 0.480921069521595 bayes_pls_golite062009
transcription repressor activity 0.256420113528322 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.248246733554633 bayes_pls_golite062009
myosin binding 0.208886721497353 bayes_pls_golite062009
catalytic activity 0.101795606736461 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [356-541]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NTKLSASTIS SALNSHGYGG HSNGYSNGNS TPAPAPPESE SSQELPLPPP PSPTQLLQYE  60
   61 AEQQVLPEPH MSTIQQPQQQ QKLEHTRTHS SLSSISSGSS SSGAQSVTNY RLQAAQNEND 120
  121 MNTQNKSPNA YNQLLKEYSN KLQQQHHHNT TQHTTATTAP SLKHNNTAKP FAVAATSTPQ 180
  181 QHLPHQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [542-729]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QHQQQPLVAA LTATLANQLK FNPHQVASSQ ATATVATVAP SAATAATAAA TPQAATATDS  60
   61 PAATASSSDN MSAYVADEPS SIYGQISAES VALAPPPPQP PTAGGGDQPF EYVTLTGNVI 120
  121 RSVQAPGKGA CPSYKVNQGY ARPFGAAAPK SPVSYPPQQQ QQSPRPAPGG QNPYATLPRS 180
  181 NVGQQVPT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [730-847]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GAQSAAKSTN LHASPQTFAT LPRPHPQATD IPAQELQKDN QLESDATSML AESVGKINMG  60
   61 DKTQAFMQEA GKIITNMLEA RLANNGGQNG PLSHAGSSLS LRSNSSSNLS KSPMIVRK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [848-1040]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RLDLDDFKNL DPTQPVALQP VIAVHSQKDL PTEVGNQKAQ PQAPRLEQTL QMELAAQHPM  60
   61 GKILDLCDGG KAIDTPEPVA FRNNLKRTGA THAADRRSYI EPKQGAINAT SVATQNGNQN 120
  121 GGQAGNQNAT QGSAPTYSVS VKALGPHSED QTTMSEENER AVSQLLKEGK RPVCCQCNKE 180
  181 ITSGPFITAL GRI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.045757
Match: 2i13A
Description: No description for 2i13A was found.

Predicted Domain #8
Region A:
Residues: [1041-1100]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WCPDHFICVN GNCRRPLQDI GFVEEKGDLY CEYCFEKYLA PTCSKCAGKI KGDCLNAIGK  60
   61 

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.74
Match: 1cxxA
Description: Cysteine-rich (intestinal) protein, CRP, CRIP
Matching Structure (courtesy of the PDB):

Predicted Domain #9
Region A:
Residues: [1101-1196]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HFHPECFTCG QCGKIFGNRP FFLEDGNAYC EADWNELFTT KCFACGFPVE AGDRWVEALN  60
   61 HNYHSQCFNC TFCKQNLEGQ SFYNKGGRPF CKNHAR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.39794
Match: 1ubdC
Description: Ying-yang 1 (yy1, zinc finger domain)
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle