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View Structure Prediction Details

Protein: Zasp52-PC
Organism: Drosophila melanogaster
Length: 1082 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Zasp52-PC.

Description E-value Query
Range
Subject
Range
gi|73984448 - gi|73984448|ref|XP_856350.1| PREDICTED: similar to Zinc finger protein 197 (ZnF20) isoform 19 [Canis...
597.0 [0..99] [1079..328]

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Predicted Domain #1
Region A:
Residues: [1-93]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAQPQLLQIK LSRFDAQPWG FRLQGGTDFA QPLLVQKVNA GSLSEQAGLQ PGDAVVKIND  60
   61 VDVFNLRHKD AQDIVVRSGN NFVITVQRGG STW

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 20.522879
Match: 1v5lA
Description: Solution structure of PDZ domain of mouse Alpha-actinin-2 associated LIM protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
structural constituent of muscle 3.94885944537237 bayes_pls_golite062009
actin binding 3.71885072001885 bayes_pls_golite062009
actinin binding 3.61513078757793 bayes_pls_golite062009
cytoskeletal protein binding 3.60106431937699 bayes_pls_golite062009
binding 3.2595117613307 bayes_pls_golite062009
protein binding 2.35875654816667 bayes_pls_golite062009
transcription regulator activity 2.16834620509051 bayes_pls_golite062009
actin filament binding 1.91421788587359 bayes_pls_golite062009
myosin binding 1.34447751574529 bayes_pls_golite062009
alpha-actinin binding 0.81785989473612 bayes_pls_golite062009
transporter activity 0.782216866213126 bayes_pls_golite062009
structural molecule activity 0.745651480925433 bayes_pls_golite062009
transmembrane transporter activity 0.699604120098573 bayes_pls_golite062009
PDZ domain binding 0.53069705861477 bayes_pls_golite062009
substrate-specific transporter activity 0.434921764966531 bayes_pls_golite062009
protein domain specific binding 0.30840185305841 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.250590541549843 bayes_pls_golite062009
molecular transducer activity 0.211809989510755 bayes_pls_golite062009
signal transducer activity 0.211809989510755 bayes_pls_golite062009
structural constituent of cytoskeleton 0.182094987832726 bayes_pls_golite062009
transcription coactivator activity 0.171693460058476 bayes_pls_golite062009
transcription activator activity 0.0433431329070377 bayes_pls_golite062009
transcription factor binding 0.0283953080227368 bayes_pls_golite062009
receptor binding 0.00333430733556384 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [94-216]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RPHVTPTGNV PQPNSPYLQT VTKTSLAHKQ QDSQHIGCGY NNAARPFSNG GDGGVKSIVN  60
   61 KQYNTPVGIY SDESIAETLS AQAEVLAGGV LGVNFKKNEK EYQGDRSEVL KFLREEETGQ 120
  121 STP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [217-520]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AFGNSHYEHD APQQLQQPQQ QYNQHQQHYH QQQQQQQSST TRHVSAPVNS PKPPSTGGLP  60
   61 TGQNICTECE RLITGVFVRI KDKNLHVECF KCATCGTSLK NQGYYNFNNK LYCDIHAKQA 120
  121 AINNPPTGTE GYVPVPIKPN TKLSASTISS ALNSHGYGGH SNGYSNGNST PAPAPPESES 180
  181 SQELPLPPPP SPTQLLQYEA EQQVLPEPHM STIQQPQQQQ KLEHTRTHSS LSSISSGSSS 240
  241 SGVGGSGSGS GSGSGVGQSQ QSYSSTLSLD RFGSPLHSRQ TSGSSTSLEV ALAAPGAGQG 300
  301 DNYT

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.76
Match: 2dfyX
Description: No description for 2dfyX was found.

Predicted Domain #4
Region A:
Residues: [521-664]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTPPSPPPPP PPQAQSVTNY RLQAAQNEND MNTQNKSPNA YNQLLKEYSN KLQQQHHHNT  60
   61 TQHTTATTAP SLKHNNTAKP FAVAATSTPQ QHLPHQQHQQ QPLVAALTAT LANQLKFNPH 120
  121 QVASSQATAT VATVAPSAAT AATA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [665-808]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AATPQAATAT DSPAATASSS DNMSAYVADE PSSIYGQISA ESVALAPPPP QPPTAGGGDQ  60
   61 PFEYVTLTGN VIRSVQAPGK GACPSYKVNQ GYARPFGAAA PKSPVSYPPQ QQQQSPRPAP 120
  121 GGQNPYATLP RSNVGQQGRN VRYQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [809-900]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QQQQQQQQYN NQQKQQYRNS YPMGSNYSTP SQSPYITSNT NNYSSSNSYN NNNYSNYNNN  60
   61 NVYRGAGGKS AGAFGATSAP KRGRGILNKA AG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.0
Match: 1tf6A
Description: Transcription factor IIIA, TFIIIA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.70988788192472 bayes_pls_golite062009
DNA binding 4.56219307357342 bayes_pls_golite062009
nucleic acid binding 4.28215395396923 bayes_pls_golite062009
transcription factor activity 3.50954949535763 bayes_pls_golite062009
binding 3.10743787485868 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.31369346002275 bayes_pls_golite062009
cytoskeletal protein binding 2.22104591928521 bayes_pls_golite062009
transcription activator activity 2.19952417915035 bayes_pls_golite062009
transcription repressor activity 1.64349785387632 bayes_pls_golite062009
sequence-specific DNA binding 1.42975942698743 bayes_pls_golite062009
transcription factor binding 1.39608963544799 bayes_pls_golite062009
chromatin binding 1.37132088004982 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.0497955246512 bayes_pls_golite062009
protein binding 1.00484935878505 bayes_pls_golite062009
transcription coactivator activity 0.912796194488319 bayes_pls_golite062009
transcription cofactor activity 0.77874411480713 bayes_pls_golite062009
tubulin binding 0.744315484113484 bayes_pls_golite062009
microtubule binding 0.576452165256057 bayes_pls_golite062009
signal transducer activity 0.274401804698955 bayes_pls_golite062009
molecular transducer activity 0.274401804698955 bayes_pls_golite062009
catalytic activity 0.245893663605433 bayes_pls_golite062009
structure-specific DNA binding 0.240825841910931 bayes_pls_golite062009
transcription corepressor activity 0.10558148421807 bayes_pls_golite062009
double-stranded DNA binding 0.0129353639725593 bayes_pls_golite062009

Predicted Domain #7
Region A:
Residues: [901-1082]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PGVRIPLCNS CNVQIRGPFI TALGRIWCPD HFICVNGNCR RPLQDIGFVE EKGDLYCEYC  60
   61 FEKYLAPTCS KCAGKIKGDC LNAIGKHFHP ECFTCGQCGK IFGNRPFFLE DGNAYCEADW 120
  121 NELFTTKCFA CGFPVEAGDR WVEALNHNYH SQCFNCTFCK QNLEGQSFYN KGGRPFCKNH 180
  181 AR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 34.221849
Match: 2i13A
Description: No description for 2i13A was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle