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View Structure Prediction Details

Protein: ent-3
Organism: Caenorhabditis elegans
Length: 729 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ent-3.

Description E-value Query
Range
Subject
Range
gi|91187847, gi|... - gi|91228615|ref|ZP_01262533.1| ATP-dependent protease LA [Vibrio alginolyticus 12G01], gi|91187847|g...
281.0 [0..17] [267..539]

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Predicted Domain #1
Region A:
Residues: [1-93]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPSTKDRQAL CKKCKKGIAT KSSRASKRLR SSKSTRSRKS VKPSKSNKKA ENEKKRQVLR  60
   61 NWITRKRREF NNEDSSSQTT SKIPKRAILF CVM

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [94-271]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TDTVKEKSAL CAIIATKRKR TKKNNKPIQI IAELRMSTKF HFKRVFEIVE KMCREQGIDD  60
   61 IDDHSYLLEV KSVNAFEGNS FSLAAGIALY AVCSGTTVKN ETIVIGKLDK TGNIEWDEYA 120
  121 EEEVKHAIKH NFQQVLMPFT NLPHVSEEHK QAIDCNGIRT FKDALELMVV HPSSMQRH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 58.39794
Match: 1rr9A
Description: Catalytic domain of E.coli Lon protease
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.06355800505512 bayes_pls_golite062009
catalytic activity 0.878454819018611 bayes_pls_golite062009
structural constituent of ribosome 0.804251312253629 bayes_pls_golite062009
ribonuclease activity 0.75307991342421 bayes_pls_golite062009
nucleic acid binding 0.728838449772752 bayes_pls_golite062009
nuclease activity 0.69721312877891 bayes_pls_golite062009
structural molecule activity 0.653141443225757 bayes_pls_golite062009
ATPase activity 0.652243617710716 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.608970207047375 bayes_pls_golite062009
pyrophosphatase activity 0.540936026536059 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.523648791725881 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.520758768874988 bayes_pls_golite062009
transcription regulator activity 0.506031376391446 bayes_pls_golite062009
3'-5'-exoribonuclease activity 0.48105441429954 bayes_pls_golite062009
3'-5' exonuclease activity 0.477960254167 bayes_pls_golite062009
DNA binding 0.413758080397896 bayes_pls_golite062009
hydrolase activity 0.405362480272149 bayes_pls_golite062009
ATPase activity, coupled 0.392367832041496 bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters 0.36703663415044 bayes_pls_golite062009
exoribonuclease activity 0.350394896843651 bayes_pls_golite062009
protein binding 0.214066724623027 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [272-729]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NAGADDVSTN DYDTFVEKSV KHTKSPESIE SGSITDQNIT DTDEVKDLGN YVFFIFMMFG  60
   61 FGALLPWNMF LNISFDYYTM FKLRSADGNA TWYSSNFQNS MTISAQIPSL VFSVINIFIA 120
  121 VKGDLTRGMK ICLIVVQLMV IVTVVFIYID TSTWIATFSM LTLGTIVVLN AANGLFQNSM 180
  181 FGLASPFPFK YTNAVIIGQN FCGTAVTVLS MLTKAASDDV QMRASLFFGL SSVAVVVCFI 240
  241 LLNFLKRLAF YKKFGILRTS SQSDEEGISS WESVKLAFEK SKMQFANIFV LFFVTLALFP 300
  301 NVCMYVKDAK KGELHSFVVP EKYFMDVVTF LNFNLFAFLG SLMANWIRFP GPNTVWICVA 360
  361 ARFWFMFYFP AANYHPMDFP RAYPVLFEST WLFAFNICIF ALTSGYLSSL IMMYAPRSHE 420
  421 DPKIQRMAGM IASFFLIFGI VAGLVFSWQI RLFMTGYA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 39.0
Match: 1pw4A
Description: Crystal Structure of the Glycerol-3-Phosphate Transporter from E.Coli
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transporter activity 4.09176719149278 bayes_pls_golite062009
substrate-specific transporter activity 3.59744164024479 bayes_pls_golite062009
transmembrane transporter activity 3.5865018981083 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 3.54194478414824 bayes_pls_golite062009
ion transmembrane transporter activity 2.21266150105753 bayes_pls_golite062009
cation transmembrane transporter activity 1.79369588808394 bayes_pls_golite062009
active transmembrane transporter activity 1.59419818573076 bayes_pls_golite062009
binding 1.45862166005114 bayes_pls_golite062009
secondary active transmembrane transporter activity 1.22264637452409 bayes_pls_golite062009
polyol transmembrane transporter activity 0.924836669821548 bayes_pls_golite062009
alcohol transmembrane transporter activity 0.924836669821548 bayes_pls_golite062009
glycerol transmembrane transporter activity 0.812001619402678 bayes_pls_golite062009
symporter activity 0.74591237387473 bayes_pls_golite062009
solute:cation symporter activity 0.74591237387473 bayes_pls_golite062009
sugar:hydrogen symporter activity 0.143419068761182 bayes_pls_golite062009
cation:sugar symporter activity 0.143419068761182 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle