YRC Public Data Repository - Protein Structure Prediction

Protein:	SUCD_ECOLI
Organism:	Escherichia coli
Length:	289 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SUCD_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|87119163, gi\|... - gi\|87119163\|ref\|ZP_01075061.1\| succinyl-CoA synthetase alpha subunit [Marinomonas sp. MED121], gi\|86...	344.0	[0..1]	[288..1]
gi\|88798686, gi\|... - gi\|88798686\|ref\|ZP_01114269.1\| succinyl-CoA synthetase alpha subunit [Reinekea sp. MED297], gi\|88778...	343.0	[0..1]	[288..1]
gi\|77956739 - gi\|77956739\|ref\|ZP_00820820.1\| COG0074: Succinyl-CoA synthetase, alpha subunit [Yersinia bercovieri ...	341.0	[0..1]	[288..1]
gi\|94498998, gi\|... - gi\|94498998\|ref\|ZP_01305536.1\| Succinyl-CoA synthetase, alpha subunit [Oceanobacter sp. RED65], gi\|9...	340.0	[0..1]	[286..1]
gi\|84779377, gi\|... - gi\|85058857\|ref\|YP_454559.1\| succinyl-CoA synthetase subunit alpha [Sodalis glossinidius str. 'morsi...	339.0	[0..1]	[288..1]
gi\|89095245, gi\|... - gi\|89095245\|ref\|ZP_01168167.1\| succinyl-CoA synthetase alpha chain [Oceanospirillum sp. MED92], gi\|8...	339.0	[0..1]	[288..1]
gi\|77866298, gi\|... - gi\|77954816\|ref\|ZP_00819202.1\| Succinyl-CoA ligase, alpha subunit [Marinobacter aquaeolei VT8], gi\|7...	339.0	[0..1]	[288..1]
gi\|89951347, gi\|... - gi\|90021747\|ref\|YP_527574.1\| succinyl-CoA synthetase (ADP-forming) alpha subunit [Saccharophagus deg...	339.0	[0..1]	[288..1]
gi\|77972479 - gi\|77972479\|ref\|ZP_00828044.1\| COG0074: Succinyl-CoA synthetase, alpha subunit [Yersinia frederiksen...	339.0	[0..1]	[289..1]
gi\|91796437, gi\|... - gi\|92113347\|ref\|YP_573275.1\| succinyl-CoA synthetase (ADP-forming) alpha subunit [Chromohalobacter s...	339.0	[0..1]	[288..1]

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Predicted Domain #1

Region A:
Residues: [1-289]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSILIDKNTK VICQGFTGSQ GTFHSEQAIA YGTKMVGGVT PGKGGTTHLG LPVFNTVREA  60
   61 VAATGATASV IYVPAPFCKD SILEAIDAGI KLIITITEGI PTLDMLTVKV KLDEAGVRMI 120
  121 GPNCPGVITP GECKIGIQPG HIHKPGKVGI VSRSGTLTYE AVKQTTDYGF GQSTCVGIGG 180
  181 DPIPGSNFID ILEMFEKDPQ TEAIVMIGEI GGSAEEEAAA YIKEHVTKPV VGYIAGVTAP 240
  241 KGKRMGHAGA IIAGGKGTAD EKFAALEAAG VKTVRSLADI GEALKTVLK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	92.39794
Match:	1jkjA
Description:	Succinyl-CoA synthetase, alpha-chain, N-terminal (CoA-binding) domain; Succinyl-CoA synthetase, alpha-chain, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
succinate-CoA ligase activity	11.5979130191209	bayes_pls_golite062009
succinate-CoA ligase (GDP-forming) activity	10.9659410855563	bayes_pls_golite062009
CoA-ligase activity	10.4192804448897	bayes_pls_golite062009
acid-thiol ligase activity	10.243481928473	bayes_pls_golite062009
ligase activity, forming carbon-sulfur bonds	9.48706872092269	bayes_pls_golite062009
succinate-CoA ligase (ADP-forming) activity	9.35325976720833	bayes_pls_golite062009
malate dehydrogenase activity	4.38786524125089	bayes_pls_golite062009
oxidoreductase activity	3.09625241707629	bayes_pls_golite062009
transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer	3.07329302783164	bayes_pls_golite062009
ligase activity	2.30626698552338	bayes_pls_golite062009
catalytic activity	1.90735517755117	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	1.65338499044318	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.47309297191111	bayes_pls_golite062009
malic enzyme activity	1.2147813077436	bayes_pls_golite062009
transferase activity, transferring acyl groups	1.15639517822408	bayes_pls_golite062009
L-malate dehydrogenase activity	1.02646414923682	bayes_pls_golite062009
ATP citrate synthase activity	0.917482134347073	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor	0.91702493082811	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	0.576163737662951	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	0.19685680097448	bayes_pls_golite062009
malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity	0.120195861875768	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	0.0913823272876781	bayes_pls_golite062009
alcohol dehydrogenase (NAD) activity	0.00644214957417527	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: