YRC Public Data Repository - Protein Structure Prediction

Protein:	ODP2_ECOLI
Organism:	Escherichia coli
Length:	630 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ODP2_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|68546239, gi\|... - gi\|68546239\|ref\|ZP_00585787.1\| Dihydrolipoamide acetyltransferase [Shewanella amazonensis SB2B], gi\|...	491.0	[0..1]	[630..1]
gi\|74310733, gi\|... - gi\|74310733\|ref\|YP_309152.1\| dihydrolipoamide acetyltransferase [Shigella sonnei Ss046], gi\|73854210...	488.0	[0..1]	[630..1]
gi\|229507527, gi... - gi\|229507527\|ref\|ZP_04397032.1\| dihydrolipoamide acetyltransferase component of pyruvate dehydrogena... gi\|75827678 - gi\|75827678\|ref\|ZP_00757113.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|75816040 - gi\|75816040\|ref\|ZP_00746523.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam...	488.0	[0..1]	[630..1]
gi\|254590650, gi... - gi\|254791250\|ref\|YP_003076087.1\| pyruvate dehydrogenase, dihydrolipoyltransacetylase component E2 [E... gi\|13359575, gi\|... - gi\|15829373\|ref\|NP_308146.1\| dihydrolipoamide acetyltransferase [Escherichia coli O157:H7], gi\|13359... gi\|209746308, gi... - pir\|\|G90643 hypothetical protein ECs0119 [imported] - Escherichia coli (strain O157:H7, substrain R... gi\|12512824, gi\|... - gi\|15799799\|ref\|NP_285811.1\| dihydrolipoamide acetyltransferase [Escherichia coli O157:H7 EDL933], g... gi\|13359575, gi\|... - gi\|15829373\|ref\|NP_308146.1\| dihydrolipoamide acetyltransferase [Escherichia coli O157:H7 str. Sakai... gi\|208741938, gi... - gi\|208821815\|ref\|ZP_03262135.1\| dihydrolipoyllysine-residue acetyltransferase [Escherichia coli O157... gi\|208735236, gi... - gi\|208813959\|ref\|ZP_03255288.1\| dihydrolipoyllysine-residue acetyltransferase [Escherichia coli O157... gi\|208805745, gi... - gi\|208805745\|ref\|ZP_03248082.1\| dihydrolipoyllysine-residue acetyltransferase [Escherichia coli O157... gi\|195938202 - gi\|195938202\|ref\|ZP_03083584.1\| dihydrolipoamide acetyltransferase [Escherichia coli O157:H7 str. EC... gi\|217320396, gi... - gi\|217324175\|ref\|ZP_03440259.1\| dihydrolipoyllysine-residue acetyltransferase [Escherichia coli O157... gi\|209160653, gi... - gi\|209399253\|ref\|YP_002268722.1\| dihydrolipoyllysine-residue acetyltransferase [Escherichia coli O15... gi\|189365209, gi... - gi\|189365209\|gb\|EDU83625.1\| dihydrolipoyllysine-residue acetyltransferase [Escherichia coli O157:H7 ... gi\|168801450, gi... - gi\|189376391\|gb\|EDU94807.1\| dihydrolipoyllysine-residue acetyltransferase [Escherichia coli O157:H7 ... gi\|168782003, gi... - gi\|189000492\|gb\|EDU69478.1\| dihydrolipoyllysine-residue acetyltransferase [Escherichia coli O157:H7 ... gi\|168776824, gi... - gi\|187767840\|gb\|EDU31684.1\| dihydrolipoyllysine-residue acetyltransferase [Escherichia coli O157:H7 ... gi\|168770416, gi... - gi\|189360706\|gb\|EDU79125.1\| dihydrolipoyllysine-residue acetyltransferase [Escherichia coli O157:H7 ...	488.0	[0..1]	[630..1]
gi\|75233842, gi\|... - gi\|75233842\|ref\|ZP_00718312.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|157076846, gi... - gi\|75189214\|ref\|ZP_00702481.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|218350313, gi... - gi\|218693581\|ref\|YP_002401248.1\| dihydrolipoamide acetyltransferase [Escherichia coli 55989], gi\|218...	488.0	[0..1]	[630..1]
gi\|46914724, gi\|... - gi\|54310283\|ref\|YP_131303.1\| dihydrolipoamide acetyltransferase [Photobacterium profundum SS9], gi\|4...	488.0	[0..1]	[630..33]
gi\|190905487, gi... - gi\|75236918\|ref\|ZP_00720980.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|218425557, gi... - gi\|218687993\|ref\|YP_002396205.1\| dihydrolipoamide acetyltransferase [Escherichia coli ED1a], gi\|2184... gi\|110341925, gi... - gi\|110640333\|ref\|YP_668061.1\| dihydrolipoamide acetyltransferase [Escherichia coli 536], gi\|11034192...	488.0	[0..1]	[630..1]
gi\|16763543, gi\|... - gi\|16763543\|ref\|NP_459158.1\| dihydrolipoamide acetyltransferase [Salmonella typhimurium LT2], gi\|164...	487.0	[0..1]	[630..1]
gi\|193063238, gi... - gi\|75258892\|ref\|ZP_00730282.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|75210442, gi\|... - gi\|75210442\|ref\|ZP_00710593.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam...	487.0	[0..1]	[630..1]
gi\|116216868, gi... - gi\|75823699\|ref\|ZP_00753184.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam...	487.0	[0..1]	[630..1]

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Predicted Domain #1

Region A:
Residues: [1-90]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAIEIKVPDI GADEVEITEI LVKVGDKVEA EQSLITVEGD KASMEVPSPQ AGIVKEIKVS  60
   61 VGDKTQTGAL IMIFDSADGA ADAAPAQAEE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	14.0
Match:	1qjoA
Description:	Ipoyl domain of dihydrolipoamide acetyltransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
dihydrolipoyllysine-residue acetyltransferase activity	7.74877411346968	bayes_pls_golite062009
S-acetyltransferase activity	7.59642806209362	bayes_pls_golite062009
dihydrolipoamide S-acyltransferase activity	7.45508609960612	bayes_pls_golite062009
pyruvate dehydrogenase activity	7.05950875585975	bayes_pls_golite062009
S-acyltransferase activity	5.24395351180663	bayes_pls_golite062009
acetyltransferase activity	3.55333192628786	bayes_pls_golite062009
acetyl-CoA carboxylase activity	3.31123635155865	bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups	2.83081843426182	bayes_pls_golite062009
CoA carboxylase activity	2.82233689048595	bayes_pls_golite062009
acyltransferase activity	2.79754636323803	bayes_pls_golite062009
ligase activity, forming carbon-carbon bonds	2.53708026587542	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	2.22092493760605	bayes_pls_golite062009
catalytic activity	1.39099902011318	bayes_pls_golite062009
binding	1.03938296760147	bayes_pls_golite062009
transferase activity, transferring acyl groups	0.629490807878017	bayes_pls_golite062009
ligase activity	0.56894584941056	bayes_pls_golite062009
protein binding	0.396415237274882	bayes_pls_golite062009
aminomethyltransferase activity	0.377624262164477	bayes_pls_golite062009
glycine dehydrogenase (decarboxylating) activity	0.0222922933292004	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor	0.0222922933292004	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [91-315]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKEAAPAAAP AAAAAKDVNV PDIGSDEVEV TEILVKVGDK VEAEQSLITV EGDKASMEVP  60
   61 APFAGTVKEI KVNVGDKVST GSLIMVFEVA GEAGAAAPAA KQEAAPAAAP APAAGVKEVN 120
  121 VPDIGGDEVE VTEVMVKVGD KVAAEQSLIT VEGDKASMEV PAPFAGVVKE LKVNVGDKVK 180
  181 TGSLIMIFEV EGAAPAAAPA KQEAAAPAPA AKAEAPAAAP AAKAE

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	5.4
Match:	1zy8K
Description:	The crystal structure of dihydrolipoamide dehydrogenase and dihydrolipoamide dehydrogenase-binding protein (didomain) subcomplex of human pyruvate dehydrogenase complex.
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [316-386]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GKSEFAENDA YVHATPLIRR LAREFGVNLA KVKGTGRKGR ILREDVQAYV KEAIKRAEAA  60
   61 PAATGGGIPG M

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	24.69897
Match:	1zy8K
Description:	The crystal structure of dihydrolipoamide dehydrogenase and dihydrolipoamide dehydrogenase-binding protein (didomain) subcomplex of human pyruvate dehydrogenase complex.
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [387-630]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPWPKVDFSK FGEIEEVELG RIQKISGANL SRNWVMIPHV THFDKTDITE LEAFRKQQNE  60
   61 EAAKRKLDVK ITPVVFIMKA VAAALEQMPR FNSSLSEDGQ RLTLKKYINI GVAVDTPNGL 120
  121 VVPVFKDVNK KGIIELSREL MTISKKARDG KLTAGEMQGG CFTISSIGGL GTTHFAPIVN 180
  181 APEVAILGVS KSAMEPVWNG KEFVPRLMLP ISLSFDHRVI DGADGARFIT IINNTLSDIR 240
  241 RLVM

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	74.69897
Match:	1dpcA
Description:	CRYSTALLOGRAPHIC AND ENZYMATIC INVESTIGATIONS ON THE ROLE OF SER558, HIS610 AND ASN614 IN THE CATALYTIC MECHANISM OF AZOTOBACTER VINELANDII DIHYDROLIPOAMIDE ACETYLTRANSFERASE (E2P)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
S-succinyltransferase activity	10.0778678835755	bayes_pls_golite062009
dihydrolipoyllysine-residue succinyltransferase activity	10.0778678835755	bayes_pls_golite062009
dihydrolipoyllysine-residue acetyltransferase activity	9.65061123545754	bayes_pls_golite062009
dihydrolipoamide S-acyltransferase activity	9.64995677986911	bayes_pls_golite062009
S-acetyltransferase activity	9.49696044977584	bayes_pls_golite062009
S-acyltransferase activity	8.45313874919036	bayes_pls_golite062009
pyruvate dehydrogenase activity	8.17557182322815	bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups	6.86215901871647	bayes_pls_golite062009
acyltransferase activity	6.83977352892719	bayes_pls_golite062009
succinyltransferase activity	6.58826720904067	bayes_pls_golite062009
pyruvate dehydrogenase (acetyl-transferring) activity	6.40483178382327	bayes_pls_golite062009
acetyltransferase activity	6.08159176722072	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	5.93985773477717	bayes_pls_golite062009
transferase activity, transferring acyl groups	4.60481199262496	bayes_pls_golite062009
alpha-ketoacid dehydrogenase activity	4.42757758312016	bayes_pls_golite062009
carnitine O-acyltransferase activity	2.87366177129153	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	2.54513901872655	bayes_pls_golite062009
catalytic activity	1.51562638409295	bayes_pls_golite062009
O-acyltransferase activity	1.33852311685118	bayes_pls_golite062009
O-palmitoyltransferase activity	1.22729402619659	bayes_pls_golite062009
carnitine O-palmitoyltransferase activity	1.22729402619659	bayes_pls_golite062009
transferase activity	1.08341671157927	bayes_pls_golite062009
carnitine O-acetyltransferase activity	1.00868366840715	bayes_pls_golite062009
binding	0.851676268990577	bayes_pls_golite062009
O-acetyltransferase activity	0.54660034926676	bayes_pls_golite062009
protein binding	0.127298422545208	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: