YRC Public Data Repository - Protein Structure Prediction

Protein:	CARB_ECOLI
Organism:	Escherichia coli
Length:	1073 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CARB_ECOLI.

Description	E-value	Query Range	Subject Range
CARB_PSESM - Carbamoyl-phosphate synthase large chain OS=Pseudomonas syringae pv. tomato GN=carB PE=3 SV=1 CARB_PSESM - Carbamoyl-phosphate synthase large chain OS=Pseudomonas syringae pv. tomato (strain DC3000) GN=carB ... gi\|213928508, gi... - gi\|213966658\|ref\|ZP_03394809.1\| carbamoyl-phosphate synthase, large subunit [Pseudomonas syringae pv...	1073.0	[0..1]	[1073..1]
gi\|104780016, gi... - gi\|95109003\|emb\|CAK13699.1\| carbamoyl-phosphate synthase, large subunit [Pseudomonas entomophila L48... gi\|95109003 - gi\|95109003\|emb\|CAK13699.1\| carbamoyl-phosphate synthase, large subunit [Pseudomonas entomophila L48...	1070.0	[0..1]	[1073..1]
gi\|71554480, gi\|... - gi\|71733927\|ref\|YP_276322.1\| carbamoyl phosphate synthase large subunit [Pseudomonas syringae pv. ph...	1070.0	[0..1]	[1073..1]
gi\|70734326, gi\|... - gi\|70734326\|ref\|YP_257966.1\| carbamoyl phosphate synthase large subunit [Pseudomonas fluorescens Pf-...	1070.0	[0..1]	[1073..1]
tr\|E4R632\|E4R632... - Carbamoyl-phosphate synthase large chain OS=Pseudomonas putida (strain BIRD-1) GN=carB PE=3 SV=1 gi\|24986476, gi\|... - gi\|26991406\|ref\|NP_746831.1\| carbamoyl-phosphate synthase large subunit [Pseudomonas putida KT2440],...	1070.0	[0..1]	[1073..4]
gi\|82737627, gi\|... - gi\|82737627\|ref\|ZP_00900474.1\| Carbamoyl-phosphate synthase, large subunit, glutamine-dependent [Pse...	1070.0	[0..1]	[1073..1]
gi\|23470946, gi\|... - gi\|66047418\|ref\|YP_237259.1\| carbamoyl phosphate synthase large subunit [Pseudomonas syringae pv. sy... tr\|F3G3S2\|F3G3S2... - Carbamoyl-phosphate synthase large chain OS=Pseudomonas syringae pv. pisi str. 1704B GN=carB PE=3 SV...	1069.0	[0..1]	[1073..1]
gi\|77380997, gi\|... - gi\|77456994\|ref\|YP_346499.1\| carbamoyl phosphate synthase large subunit [Pseudomonas fluorescens Pf0...	1067.0	[0..1]	[1073..1]
gi\|6552726 - gi\|6552726\|gb\|AAF16526.1\|AF191301_2 ADP-forming, carbamate-phosphorylating [Medicago sativa]	1065.0	[0..1]	[1073..1]

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Predicted Domain #1

Region A:
Residues: [1-1073]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPKRTDIKSI LILGAGPIVI GQACEFDYSG AQACKALREE GYRVILVNSN PATIMTDPEM  60
   61 ADATYIEPIH WEVVRKIIEK ERPDAVLPTM GGQTALNCAL ELERQGVLEE FGVTMIGATA 120
  121 DAIDKAEDRR RFDVAMKKIG LETARSGIAH TMEEALAVAA DVGFPCIIRP SFTMGGSGGG 180
  181 IAYNREEFEE ICARGLDLSP TKELLIDESL IGWKEYEMEV VRDKNDNCII VCSIENFDAM 240
  241 GIHTGDSITV APAQTLTDKE YQIMRNASMA VLREIGVETG GSNVQFAVNP KNGRLIVIEM 300
  301 NPRVSRSSAL ASKATGFPIA KVAAKLAVGY TLDELMNDIT GGRTPASFEP SIDYVVTKIP 360
  361 RFNFEKFAGA NDRLTTQMKS VGEVMAIGRT QQESLQKALR GLEVGATGFD PKVSLDDPEA 420
  421 LTKIRRELKD AGADRIWYIA DAFRAGLSVD GVFNLTNIDR WFLVQIEELV RLEEKVAEVG 480
  481 ITGLNADFLR QLKRKGFADA RLAKLAGVRE AEIRKLRDQY DLHPVYKRVD TCAAEFATDT 540
  541 AYMYSTYEEE CEANPSTDRE KIMVLGGGPN RIGQGIEFDY CCVHASLALR EDGYETIMVN 600
  601 CNPETVSTDY DTSDRLYFEP VTLEDVLEIV RIEKPKGVIV QYGGQTPLKL ARALEAAGVP 660
  661 VIGTSPDAID RAEDRERFQH AVERLKLKQP ANATVTAIEM AVEKAKEIGY PLVVRPSYVL 720
  721 GGRAMEIVYD EADLRRYFQT AVSVSNDAPV LLDHFLDDAV EVDVDAICDG EMVLIGGIME 780
  781 HIEQAGVHSG DSACSLPAYT LSQEIQDVMR QQVQKLAFEL QVRGLMNVQF AVKNNEVYLI 840
  841 EVNPRAARTV PFVSKATGVP LAKVAARVMA GKSLAEQGVT KEVIPPYYSV KEVVLPFNKF 900
  901 PGVDPLLGPE MRSTGEVMGV GRTFAEAFAK AQLGSNSTMK KHGRALLSVR EGDKERVVDL 960
  961 AAKLLKQGFE LDATHGTAIV LGEAGINPRL VNKVHEGRPH IQDRIKNGEY TYIINTTSGR1020
 1021 RAIEDSRVIR RSALQYKVHY DTTLNGGFAT AMALNADATE KVISVQEMHA QIK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1bxrA
Description:	Carbamoyl phosphate synthetase, large subunit connection domain; Carbamoyl phosphate synthetase, large subunit allosteric, C-terminal domain; Carbamoyl phosphate synthetase (CPS), large subunit PreATP-grasp domains; Carbamoyl phosphate synthetase (CPS), large subunit ATP-binding domains
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
carbamoyl-phosphate synthase activity	10.3961907577933	bayes_pls_golite062009
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	10.3817460390594	bayes_pls_golite062009
carbon-nitrogen ligase activity, with glutamine as amido-N-donor	7.55690629692775	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	6.95559501787172	bayes_pls_golite062009
ligase activity	1.91091941710895	bayes_pls_golite062009
phosphoribosylaminoimidazole carboxylase activity	1.57708889650281	bayes_pls_golite062009
catalytic activity	1.08688404807699	bayes_pls_golite062009
phosphoribosylamine-glycine ligase activity	1.04915286326924	bayes_pls_golite062009
carbon-oxygen lyase activity, acting on phosphates	0.964679554894316	bayes_pls_golite062009
phosphoribosylaminoimidazolecarboxamide formyltransferase activity	0.898425265043358	bayes_pls_golite062009
acid-amino acid ligase activity	0.730894973410499	bayes_pls_golite062009
carbon-oxygen lyase activity	0.482425669839603	bayes_pls_golite062009
ligase activity, forming carbon-sulfur bonds	0.37779550230552	bayes_pls_golite062009
methylglyoxal synthase activity	0.352197422887157	bayes_pls_golite062009
glutathione synthase activity	0.0685848191991462	bayes_pls_golite062009
biotin carboxylase activity	0.0172732430077291	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: