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View Structure Prediction Details

Protein: GCL_ECOLI
Organism: Escherichia coli
Length: 593 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GCL_ECOLI.

Description E-value Query
Range
Subject
Range
gi|77977565 - gi|77977565|ref|ZP_00833010.1| COG0028: Thiamine pyrophosphate-requiring enzymes [acetolactate synth...
610.0 [0..1] [577..11]
gi|106884385, gi... - gi|119947033|ref|YP_944713.1| acetolactate synthase, large subunit, biosynthetic type [Psychromonas ...
609.0 [0..1] [580..1]
gi|77958248 - gi|77958248|ref|ZP_00822285.1| COG0028: Thiamine pyrophosphate-requiring enzymes [acetolactate synth...
609.0 [0..1] [577..17]
gi|77962085 - gi|77962085|ref|ZP_00825910.1| COG0028: Thiamine pyrophosphate-requiring enzymes [acetolactate synth...
609.0 [0..1] [577..11]
gi|222054607, gi... - gi|222054607|ref|YP_002536969.1| acetolactate synthase, large subunit, biosynthetic type [Geobacter ...
609.0 [0..2] [573..1]
gi|7436698 - pir||C70341 acetolactate synthase (EC 4.1.3.18) large chain - Aquifex aeolicus
gi|15605942, gi|... - gi|2983101|gb|AAC06706.1| acetolactate synthase large subunit [Aquifex aeolicus VF5], gi|15605942|re...
608.0 [0..1] [574..1]
gi|146399240, gi... - gi|88936939|ref|ZP_01142531.1| Acetolactate synthase, large subunit, biosynthetic type [Geobacter ur...
607.0 [0..2] [573..1]
gi|77976113 - gi|77976113|ref|ZP_00831646.1| COG0028: Thiamine pyrophosphate-requiring enzymes [acetolactate synth...
606.0 [0..1] [577..26]
gi|89048720, gi|... - gi|89075580|ref|ZP_01161985.1| acetolactate synthase III large subunit [Photobacterium sp. SKA34], g...
604.0 [0..1] [577..1]
gi|37527530, gi|... - gi|37527530|ref|NP_930874.1| acetolactate synthase 3 catalytic subunit [Photorhabdus luminescens sub...
603.0 [0..1] [577..1]

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Predicted Domain #1
Region A:
Residues: [1-593]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKMRAVDAA MYVLEKEGIT TAFGVPGAAI NPFYSAMRKH GGIRHILARH VEGASHMAEG  60
   61 YTRATAGNIG VCLGTSGPAG TDMITALYSA SADSIPILCI TGQAPRARLH KEDFQAVDIE 120
  121 AIAKPVSKMA VTVREAALVP RVLQQAFHLM RSGRPGPVLV DLPFDVQVAE IEFDPDMYEP 180
  181 LPVYKPAASR MQIEKAVEML IQAERPVIVA GGGVINADAA ALLQQFAELT SVPVIPTLMG 240
  241 WGCIPDDHEL MAGMVGLQTA HRYGNATLLA SDMVFGIGNR FANRHTGSVE KYTEGRKIVH 300
  301 IDIEPTQIGR VLCPDLGIVS DAKAALTLLV EVAQEMQKAG RLPCRKEWVA DCQQRKRTLL 360
  361 RKTHFDNVPV KPQRVYEEMN KAFGRDVCYV TTIGLSQIAA AQMLHVFKDR HWINCGQAGP 420
  421 LGWTIPAALG VCAADPKRNV VAISGDFDFQ FLIEELAVGA QFNIPYIHVL VNNAYLGLIR 480
  481 QSQRAFDMDY CVQLAFENIN SSEVNGYGVD HVKVAEGLGC KAIRVFKPED IAPAFEQAKA 540
  541 LMAQYRVPVV VEVILERVTN ISMGSELDNV MEFEDIADNA ADAPTETCFM HYE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 156.0
Match: 1ybhA
Description: Crystal structure of Arabidopsis thaliana Acetohydroxyacid synthase In Complex With A Sulfonylurea Herbicide Chlorimuron Ethyl
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
acetolactate synthase activity 12.903449876837 bayes_pls_golite062009
transferase activity, transferring aldehyde or ketonic groups 12.3239025230705 bayes_pls_golite062009
pyruvate dehydrogenase activity 5.28857071459273 bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor 5.21233670052586 bayes_pls_golite062009
pyruvate dehydrogenase (acetyl-transferring) activity 5.08663245333808 bayes_pls_golite062009
transcription regulator activity 2.51117258094456 bayes_pls_golite062009
transketolase activity 2.50501741089295 bayes_pls_golite062009
catalytic activity 2.25537597692103 bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors 2.15444163802756 bayes_pls_golite062009
DNA binding 2.09930834951157 bayes_pls_golite062009
deoxyhypusine synthase activity 2.04735838056767 bayes_pls_golite062009
nucleic acid binding 2.00972611627502 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 1.98546381612935 bayes_pls_golite062009
NAD-dependent protein deacetylase activity 1.93141177609772 bayes_pls_golite062009
NAD-dependent histone deacetylase activity 1.93141177609772 bayes_pls_golite062009
histone deacetylase activity 1.91254869751164 bayes_pls_golite062009
protein deacetylase activity 1.90521776801103 bayes_pls_golite062009
oxidoreductase activity 1.85833680148029 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 1.82969293063325 bayes_pls_golite062009
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity 1.65348126142808 bayes_pls_golite062009
alpha-ketoacid dehydrogenase activity 1.20517690263403 bayes_pls_golite062009
binding 1.17940168894417 bayes_pls_golite062009
transcription factor binding 1.07103864164531 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 1.0611726850452 bayes_pls_golite062009
transcription factor activity 1.0180828203704 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH 0.982646671777 bayes_pls_golite062009
deacetylase activity 0.977680867213479 bayes_pls_golite062009
cation transmembrane transporter activity 0.78591260444574 bayes_pls_golite062009
tartronate-semialdehyde synthase activity 0.591485766507531 bayes_pls_golite062009
hydrolase activity 0.536729211484905 bayes_pls_golite062009
transcription repressor activity 0.516307124442946 bayes_pls_golite062009
ion transmembrane transporter activity 0.51426028502998 bayes_pls_golite062009
transcription cofactor activity 0.42635585193838 bayes_pls_golite062009
transferase activity 0.413024577830522 bayes_pls_golite062009
transcription corepressor activity 0.23414654967509 bayes_pls_golite062009
pyruvate decarboxylase activity 0.198062360371269 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.114062221123972 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle