YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|44970588
Organism:	Plasmodium falciparum
Length:	608 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|44970588.

Description	E-value	Query Range	Subject Range
gi\|84361587 - gi\|84361587\|ref\|ZP_00986249.1\| COG0567: 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) com...	360.0	[0..23]	[602..1]
gi\|91686951, gi\|... - gi\|91782997\|ref\|YP_558203.1\| alpha-ketoglutarate decarboxylase [Burkholderia xenovorans LB400], gi\|9...	360.0	[0..22]	[601..1]
gi\|124384081, gi... - gi\|124384081\|ref\|YP_001026171.1\| 2-oxoglutarate dehydrogenase E1 component [Burkholderia mallei NCTC... gi\|194575270, gi... - gi\|254358395\|ref\|ZP_04974668.1\| 2-oxoglutarate dehydrogenase, E1 component [Burkholderia mallei 2002... gi\|121598805, gi... - gi\|121598805\|ref\|YP_992828.1\| 2-oxoglutarate dehydrogenase E1 component [Burkholderia mallei SAVP1],... gi\|254206023, gi... - gi\|254206023\|ref\|ZP_04912375.1\| 2-oxoglutarate dehydrogenase, E1 component [Burkholderia mallei JHU]... gi\|147749296, gi... - gi\|254199700\|ref\|ZP_04906066.1\| 2-oxoglutarate dehydrogenase, E1 component [Burkholderia mallei FMH]... gi\|126450583, gi... - gi\|126450583\|ref\|YP_001080559.1\| alpha-ketoglutarate decarboxylase [Burkholderia mallei NCTC 10247],... gi\|160698776, gi... - gi\|254177737\|ref\|ZP_04884392.1\| 2-oxoglutarate dehydrogenase, E1 component [Burkholderia mallei ATCC... gi\|243063185, gi... - gi\|243063185\|gb\|EES45371.1\| 2-oxoglutarate dehydrogenase, E1 component [Burkholderia mallei PRL-20],... gi\|53724834, gi\|... - gi\|53724834\|ref\|YP_102751.1\| alpha-ketoglutarate decarboxylase [Burkholderia mallei ATCC 23344], gi\|... gi\|238519813, gi... - gi\|238563860\|ref\|ZP_00438154.2\| oxoglutarate dehydrogenase (succinyl-transferring), E1 component [Bu...	358.0	[0..22]	[602..4]
gi\|167582078 - gi\|167582078\|ref\|ZP_02374952.1\| alpha-ketoglutarate decarboxylase [Burkholderia thailandensis TXDOH] gi\|83719912, gi\|... - gi\|83719912\|ref\|YP_443073.1\| alpha-ketoglutarate decarboxylase [Burkholderia thailandensis E264], gi... gi\|167620239 - gi\|167620239\|ref\|ZP_02388870.1\| alpha-ketoglutarate decarboxylase [Burkholderia thailandensis Bt4]	358.0	[0..22]	[602..4]
gi\|126220338, gi... - gi\|126440845\|ref\|YP_001058789.1\| alpha-ketoglutarate decarboxylase [Burkholderia pseudomallei 668], ... gi\|254197805, gi... - gi\|254197805\|ref\|ZP_04904227.1\| 2-oxoglutarate dehydrogenase, E1 component [Burkholderia pseudomalle... gi\|167919179 - gi\|167919179\|ref\|ZP_02506270.1\| alpha-ketoglutarate decarboxylase [Burkholderia pseudomallei BCC215] gi\|126453274, gi... - gi\|126453274\|ref\|YP_001066041.1\| alpha-ketoglutarate decarboxylase [Burkholderia pseudomallei 1106a]... gi\|217393228, gi... - gi\|217423370\|ref\|ZP_03454871.1\| 2-oxoglutarate dehydrogenase, E1 component [Burkholderia pseudomalle... gi\|167894515 - gi\|167894515\|ref\|ZP_02481917.1\| alpha-ketoglutarate decarboxylase [Burkholderia pseudomallei 7894] gi\|167845938 - gi\|167845938\|ref\|ZP_02471446.1\| alpha-ketoglutarate decarboxylase [Burkholderia pseudomallei B7210] gi\|167911156 - gi\|167911156\|ref\|ZP_02498247.1\| alpha-ketoglutarate decarboxylase [Burkholderia pseudomallei 112] gi\|167902917 - gi\|167902917\|ref\|ZP_02490122.1\| alpha-ketoglutarate decarboxylase [Burkholderia pseudomallei NCTC 13... gi\|167738808 - gi\|167738808\|ref\|ZP_02411582.1\| alpha-ketoglutarate decarboxylase [Burkholderia pseudomallei 14] gi\|167719807 - gi\|167719807\|ref\|ZP_02403043.1\| alpha-ketoglutarate decarboxylase [Burkholderia pseudomallei DM98] gi\|167824406 - gi\|167824406\|ref\|ZP_02455877.1\| alpha-ketoglutarate decarboxylase [Burkholderia pseudomallei 9] gi\|167816031 - gi\|167816031\|ref\|ZP_02447711.1\| alpha-ketoglutarate decarboxylase [Burkholderia pseudomallei 91] gi\|134246378, gi... - gi\|134282340\|ref\|ZP_01769045.1\| 2-oxoglutarate dehydrogenase, E1 component [Burkholderia pseudomalle... gi\|161369476, gi... - gi\|254260360\|ref\|ZP_04951414.1\| oxoglutarate dehydrogenase (succinyl-transferring), E1 component [Bu... gi\|242138724, gi... - gi\|242315485\|ref\|ZP_04814501.1\| oxoglutarate dehydrogenase (succinyl-transferring), E1 component [Bu... gi\|76809454, gi\|... - gi\|76809454\|ref\|YP_333323.1\| alpha-ketoglutarate decarboxylase [Burkholderia pseudomallei 1710b], gi... gi\|237503906, gi... - gi\|237812051\|ref\|YP_002896502.1\| oxoglutarate dehydrogenase (succinyl-transferring), E1 component [B... gi\|53719523, gi\|... - gi\|53719523\|ref\|YP_108509.1\| alpha-ketoglutarate decarboxylase [Burkholderia pseudomallei K96243], g...	358.0	[0..22]	[602..4]
gi\|67639279 - gi\|67639279\|ref\|ZP_00438154.1\| COG0567: 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) com... gi\|67647642 - gi\|67647642\|ref\|ZP_00445882.1\| COG0567: 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) com... gi\|84522882 - gi\|84522882\|ref\|ZP_01010018.1\| COG0567: 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) com... gi\|85064703 - gi\|85064703\|ref\|ZP_01025556.1\| COG0567: 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) com... gi\|87315445, gi\|... - gi\|87315445\|ref\|ZP_01096473.1\| COG0567: 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) com... gi\|83619454 - gi\|83619454\|ref\|ZP_00929889.1\| COG0567: 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) com... gi\|83624429 - gi\|83624429\|ref\|ZP_00934677.1\| COG0567: 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) com... gi\|100918360, gi... - gi\|67638744\|ref\|ZP_00437679.1\| COG0567: 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) com...	357.0	[0..23]	[602..1]
gi\|194571325, gi... - gi\|83676653\|ref\|ZP_00938428.1\| COG0567: 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) com... gi\|99907898, gi\|... - gi\|99907898\|ref\|ZP_01315709.1\| hypothetical protein Bpse1_03004958 [Burkholderia pseudomallei 1655],... gi\|82528339 - gi\|82528339\|ref\|ZP_00887618.1\| COG0567: 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) com... gi\|82534552 - gi\|82534552\|ref\|ZP_00893584.1\| hypothetical protein Bpse110_02004160 [Burkholderia pseudomallei 1106... gi\|100059156, gi... - gi\|67753174\|ref\|ZP_00492119.1\| COG0567: 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) com... gi\|67758457, gi\|... - gi\|67758457\|ref\|ZP_00497222.1\| COG0567: 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) com... gi\|67681199, gi\|... - gi\|90290796\|ref\|ZP_01210440.1\| hypothetical protein Bpse17_02004503 [Burkholderia pseudomallei 1710a... gi\|67737779 - gi\|67737779\|ref\|ZP_00488511.1\| COG0567: 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) com... gi\|226199718, gi... - gi\|226199718\|ref\|ZP_03795271.1\| 2-oxoglutarate dehydrogenase, E1 component [Burkholderia pseudomalle...	357.0	[0..23]	[602..1]
gi\|67666907, gi\|... - gi\|67666907\|ref\|ZP_00464144.1\| Dehydrogenase, E1 component [Burkholderia cenocepacia HI2424], gi\|670... gi\|118652105, gi... - gi\|170732834\|ref\|YP_001764781.1\| 2-oxoglutarate dehydrogenase E1 component [Burkholderia cenocepacia... gi\|105892770, gi... - gi\|67656265\|ref\|ZP_00453648.1\| Dehydrogenase, E1 component [Burkholderia cenocepacia AU 1054], gi\|67... gi\|194556563, gi... - gi\|254245578\|ref\|ZP_04938899.1\| Dehydrogenase, E1 component [Burkholderia cenocepacia PC184], gi\|194...	356.0	[0..22]	[602..4]
gi\|77966864, gi\|... - gi\|78066119\|ref\|YP_368888.1\| alpha-ketoglutarate decarboxylase [Burkholderia sp. 383], gi\|77966864\|g...	355.0	[0..22]	[602..4]
gi\|115351443, gi... - gi\|74016024\|ref\|ZP_00686651.1\| Dehydrogenase, E1 component [Burkholderia ambifaria AMMD], gi\|7261145... gi\|170700014, gi... - gi\|170700014\|ref\|ZP_02891039.1\| 2-oxoglutarate dehydrogenase, E1 subunit [Burkholderia ambifaria IOP...	355.0	[0..22]	[602..4]

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Predicted Domain #1

Region A:
Residues: [1-104]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLLVIWLNIF WFIPYYCFNY VLCVGNKNDM LFVKNKNLIY PYNDMNRIRR HKGVELSRKM  60
   61 VAENIQMRNM KSNNNSNNVH ENNNIDHSNN YNNNLYLSCS NKKK

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [105-608]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GKDVQSLCAI KHGNVLIKNI NEEEKEKGIK KNDTDKLESK NDNEHKNEEN NFVFSYDKKL  60
   61 NNYSEFNIYM ENNNIEEYIS DVNISREEIC TLYEDMYLGR LFENLVAKLY YNKRVNGFVH 120
  121 LYNGQEAVST GIIKNLKNSD FVTSTYRDHV HALSKGVPAH KILNELYGNY YGSTNKGKGG 180
  181 SMHIYSKENN FIGGFGFIGE QIPIAVGLAY SILYKNEFHY NPKNTSFTST KNKNNYIQEN 240
  241 ENMIHMNNSQ NVDVVVCFLG DGTTNIGQFF ESLNLASSYN LPIIFVIENN NWAIGMESSR 300
  301 SSSDDLMNNY SKGKAFNIDT FKVDGNDVLT IYKLAKKKIQ QIRNRTSGPI IIEAITYRAK 360
  361 GHSLADPDEL RIKEEKTSWK KRDPILFLSS YMKKYNLVQE SYFEQVKKNT QTLLQQAELD 420
  421 AEQNTKKGEH IDICNVIQQN IFAPSKSTPY QSEYENYKQF DDISNDELKE YYQEVLKEIQ 480
  481 RKKEKKKLDP NDKFDQKKLP LIID

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	64.30103
Match:	1ni4A
Description:	E1-beta subunit of pyruvate dehydrogenase (PP module)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
pyruvate dehydrogenase activity	11.3856674722026	bayes_pls_golite062009
pyruvate dehydrogenase (acetyl-transferring) activity	11.0549577473177	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	10.8180381281695	bayes_pls_golite062009
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity	7.00951713446616	bayes_pls_golite062009
alpha-ketoacid dehydrogenase activity	6.25236550086321	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	4.89064211833637	bayes_pls_golite062009
acetolactate synthase activity	4.51986503762195	bayes_pls_golite062009
transferase activity, transferring aldehyde or ketonic groups	3.8269109174531	bayes_pls_golite062009
2-oxoisovalerate dehydrogenase (acylating) activity	3.00128844859152	bayes_pls_golite062009
cyclin-dependent protein kinase 5 activator regulator activity	3.00128844859152	bayes_pls_golite062009
catalytic activity	2.25537597692103	bayes_pls_golite062009
oxidoreductase activity	1.85833680148029	bayes_pls_golite062009
transketolase activity	1.53492491341322	bayes_pls_golite062009
protein binding	0.992849906276347	bayes_pls_golite062009
binding	0.750068469698571	bayes_pls_golite062009
transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer	0.667418924427388	bayes_pls_golite062009
pyruvate decarboxylase activity	0.198062360371269	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: