YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|30264663, gi\|...
Organism:	Bacillus anthracis str. Ames
Length:	312 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|30264663, gi|....

Description	E-value	Query Range	Subject Range
gi\|89100383, gi\|... - gi\|89100383\|ref\|ZP_01173247.1\| malate dehydrogenase [Bacillus sp. NRRL B-14911], gi\|89084902\|gb\|EAR6...	2.0E-81	[1..311]	[1..311]
MDH_GEOKA - Malate dehydrogenase OS=Geobacillus kaustophilus GN=mdh PE=3 SV=1 MDH_GEOKA - Malate dehydrogenase OS=Geobacillus kaustophilus (strain HTA426) GN=mdh PE=3 SV=1	2.0E-81	[1..311]	[1..311]
gi\|73988677 - gi\|73988677\|ref\|XP_534084.2\| PREDICTED: similar to L-lactate dehydrogenase A chain (LDH-A) (LDH musc...	1.0E-80	[4..311]	[48..359]
MDH_BACCZ - Malate dehydrogenase OS=Bacillus cereus (strain ZK / E33L) GN=mdh PE=3 SV=1	1.0E-80	[1..312]	[1..312]
gi\|228647988, gi... - gi\|229135427\|ref\|ZP_04264214.1\| Malate dehydrogenase [Bacillus cereus BDRD-ST196], gi\|228647988\|gb\|E... MDH_BACWK - Malate dehydrogenase OS=Bacillus weihenstephanensis (strain KBAB4) GN=mdh PE=3 SV=1	1.0E-80	[1..312]	[1..312]
gi\|221315179 - gi\|221315179\|ref\|ZP_03596984.1\| malate dehydrogenase [Bacillus subtilis subsp. subtilis str. NCIB 36... MDH_BACSU - Malate dehydrogenase OS=Bacillus subtilis GN=mdh PE=1 SV=3 MDH_BACSU - Malate dehydrogenase OS=Bacillus subtilis (strain 168) GN=mdh PE=1 SV=3 gi\|221324378 - gi\|221324378\|ref\|ZP_03605672.1\| malate dehydrogenase [Bacillus subtilis subsp. subtilis str. SMY] gi\|221320096 - gi\|221320096\|ref\|ZP_03601390.1\| malate dehydrogenase [Bacillus subtilis subsp. subtilis str. JH642]	1.0E-80	[1..311]	[1..311]
gi\|82395824 - gi\|82395824\|gb\|ABB72476.1\| malate dehydrogenase [Geobacillus thermodenitrificans] MDH_GEOTN - Malate dehydrogenase OS=Geobacillus thermodenitrificans (strain NG80-2) GN=mdh PE=3 SV=1 gi\|196210431, gi... - gi\|196249917\|ref\|ZP_03148612.1\| malate dehydrogenase, NAD-dependent [Geobacillus sp. G11MC16], gi\|19...	1.0E-80	[1..311]	[1..311]
MDH_BACIS - Malate dehydrogenase OS=Bacillus israeli GN=mdh PE=3 SV=1	3.0E-80	[1..312]	[1..312]
MDH_BACCR - Malate dehydrogenase OS=Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / NCIMB ... gi\|229129876, gi... - gi\|229129876\|ref\|ZP_04258842.1\| Malate dehydrogenase [Bacillus cereus BDRD-Cer4], gi\|228653567\|gb\|EE... gi\|229147152, gi... - gi\|229147152\|ref\|ZP_04275510.1\| Malate dehydrogenase [Bacillus cereus BDRD-ST24], gi\|228636262\|gb\|EE... gi\|229048299, gi... - gi\|229048299\|ref\|ZP_04193867.1\| Malate dehydrogenase [Bacillus cereus AH676], gi\|228723024\|gb\|EEL744... gi\|228671381, gi... - gi\|229112058\|ref\|ZP_04241601.1\| Malate dehydrogenase [Bacillus cereus Rock1-15], gi\|228671381\|gb\|EEL...	3.0E-80	[1..312]	[1..312]

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Predicted Domain #1

Region A:
Residues: [1-312]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTIKRKKVSV IGAGFTGATT AFLLAQKELA DVVLVDIPQL ENPTKGKALD MLEASPVQGF  60
   61 DANIIGTSDY ADTADSDVVV ITAGIARKPG MSRDDLVATN SKIMKSITRD IAKHSPNAII 120
  121 VVLTNPVDAM TYSVFKEAGF PKERVIGQSG VLDTARFRTF IAQELNLSVK DITGFVLGGH 180
  181 GDDMVPLVRY SYAGGIPLET LIPKERLEAI VERTRKGGGE IVGLLGNGSA YYAPAASLVE 240
  241 MTEAILKDQR RVLPAIAYLE GEYGYSDLYL GVPVILGGNG IEKIIELELL ADEKEALDRS 300
  301 VESVRNVMKV LV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	69.39794
Match:	1guzA
Description:	Malate dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
malate dehydrogenase activity	3.73899222825747	bayes_pls_golite062009
alcohol dehydrogenase (NAD) activity	2.94416173750168	bayes_pls_golite062009
L-lactate dehydrogenase activity	2.59062377380589	bayes_pls_golite062009
alcohol dehydrogenase activity, zinc-dependent	2.26153457113968	bayes_pls_golite062009
catalytic activity	1.79741889688267	bayes_pls_golite062009
retinol dehydrogenase activity	1.16811519855038	bayes_pls_golite062009
binding	0.982999356179965	bayes_pls_golite062009
oxidoreductase activity	0.9367410227151	bayes_pls_golite062009
NAD or NADH binding	0.74536049628503	bayes_pls_golite062009
fatty acid synthase activity	0.714637370305282	bayes_pls_golite062009
DNA binding	0.525227236870065	bayes_pls_golite062009
protein binding	0.507836099271263	bayes_pls_golite062009
nucleic acid binding	0.459537641913493	bayes_pls_golite062009
malic enzyme activity	0.431922445809582	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	0.418775403210681	bayes_pls_golite062009
coenzyme binding	0.35922330382799	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	0.32207755075663	bayes_pls_golite062009
3-oxoacyl-[acyl-carrier-protein] reductase activity	0.192594057004213	bayes_pls_golite062009
transcription regulator activity	0.177044638410302	bayes_pls_golite062009
malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity	0.120195861875768	bayes_pls_golite062009
molecular transducer activity	0.0433763403499039	bayes_pls_golite062009
signal transducer activity	0.0433763403499039	bayes_pls_golite062009
formate dehydrogenase activity	4.92199819939532E-4	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: