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View Structure Prediction Details

Protein: PIN4_YEAST
Organism: Saccharomyces cerevisiae S288c
Length: 668 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PIN4_YEAST.

Description E-value Query
Range		 Subject
Range
PIN4 - Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contai...
PIN4_YEAST - RNA-binding protein PIN4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PIN4 PE=1 SV=1
 0.0 [1..668] [1..668]
gi|19526272 - gi|19526272|gb|AAL89666.1|AF411956_7 polyA-binding protein [Takifugu rubripes]
 0.0 [1..529] [26..545]
PABP1_BOVIN - Polyadenylate-binding protein 1 OS=Bos taurus GN=PABPC1 PE=2 SV=1
gi|109087089 - gi|109087089|ref|XP_001098239.1| PREDICTED: poly(A) binding protein, cytoplasmic 1 isoform 2 [Macaca...
gi|123993665, gi... - gi|168278070|dbj|BAG11013.1| polyadenylate-binding protein 1 [synthetic construct], gi|123999981|gb|...
gi|194036975 - gi|194036975|ref|XP_001927782.1| PREDICTED: similar to Polyadenylate-binding protein 1 (Poly(A)-bind...
PABPC1 - poly(A) binding protein, cytoplasmic 1
gi|73974130, gi|... - gi|73974178|ref|XP_857695.1| PREDICTED: similar to Polyadenylate-binding protein 1 (Poly(A)-binding ...
 0.0 [1..529] [26..561]
PABP1_MOUSE - Polyadenylate-binding protein 1 OS=Mus musculus GN=Pabpc1 PE=1 SV=2
 0.0 [1..529] [26..561]
PABP1_RAT - Polyadenylate-binding protein 1 OS=Rattus norvegicus GN=Pabpc1 PE=1 SV=1
 0.0 [1..529] [26..561]
gi|64970 - gi|64970|emb|CAA40721.1| polyA binding protein [Xenopus laevis]
 0.0 [1..529] [26..559]

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Predicted Domain #1
Region A:
Residues: [1-74] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 METSSFENAP PAAINDAQDN NINTETNDQE TNQQSIETRD AIDKENGVQT ETGENSAKNA  60
   61 EQNVSSTNLN NAPT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 47.221849
Match: 1cvjA_
Description: Poly(A)-binding protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleic acid binding 3.64594243387558 bayes_pls_golite062009
binding 3.00411894202318 bayes_pls_golite062009
mRNA binding 2.76744192669109 bayes_pls_golite062009
RNA binding 2.41328743949172 bayes_pls_golite062009
protein binding 1.12215421354121 bayes_pls_golite062009
transcription regulator activity 0.737458867828906 bayes_pls_golite062009
DNA binding 0.691258294213766 bayes_pls_golite062009
mRNA 3'-UTR binding 0.599389001184667 bayes_pls_golite062009
translation regulator activity 0.38120065819101 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.128616879457381 bayes_pls_golite062009
structural molecule activity 0.0829058000493267 bayes_pls_golite062009
structure-specific DNA binding 0.0666589824195664 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [75-164] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NGALDDDVIP NAIVIKNIPF AIKKEQLLDI IEEMDLPLPY AFNYHFDNGI FRGLAFANFT  60
   61 TPEETTQVIT SLNGKEISGR KLKVEYKKML

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 57.0
Match: 1up1__
Description: Nuclear ribonucleoprotein A1 (RNP A1, UP1)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleic acid binding 3.64594243387558 bayes_pls_golite062009
binding 3.00411894202318 bayes_pls_golite062009
mRNA binding 2.76744192669109 bayes_pls_golite062009
RNA binding 2.41328743949172 bayes_pls_golite062009
protein binding 1.12215421354121 bayes_pls_golite062009
transcription regulator activity 0.737458867828906 bayes_pls_golite062009
DNA binding 0.691258294213766 bayes_pls_golite062009
mRNA 3'-UTR binding 0.599389001184667 bayes_pls_golite062009
translation regulator activity 0.38120065819101 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.128616879457381 bayes_pls_golite062009
structural molecule activity 0.0829058000493267 bayes_pls_golite062009
structure-specific DNA binding 0.0666589824195664 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [165-300] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PQAERERIER EKREKRGQLE EQHRSSSNLS LDSLSKMSGS GNNNTSNNQL FSTLMNGINA  60
   61 NSMMNSPMNN TINNNSSNNN NSGNIILNQP SLSAQHTSSS LYQTNVNNQA QMSTERFYAP 120
  121 LPSTSTLPLP PQQLDF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 57.0
Match: 1up1__
Description: Nuclear ribonucleoprotein A1 (RNP A1, UP1)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.45278097493666 bayes_pls_golite062009
nucleic acid binding 1.29585787691257 bayes_pls_golite062009
DNA binding 1.21862098093327 bayes_pls_golite062009
transcription regulator activity 1.06027197080527 bayes_pls_golite062009
protein binding 0.741098311996669 bayes_pls_golite062009
catalytic activity 0.307971467423079 bayes_pls_golite062009
structure-specific DNA binding 0.0146459886075777 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [301-443] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDPDTLEIYS QLLLFKDREK YYYELAYPMG ISASHKRIIN VLCSYLGLVE VYDPRFIIIR  60
   61 RKILDHANLQ SHLQQQGQMT SAHPLQPNST GGSMNRSQSY TSLLQAHAAA AANSISNQAV 120
  121 NNSSNSNTIN SNNGNGNNVI INN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [444-530] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSASSTPKIS SQGQFSMQPT LTSPKMNIHH SSQYNSADQP QQPQPQTQQN VQSAAQQQQS  60
   61 FLRQQATLTP SSRIPSGYSA NHYQINS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.522879
Match: 1g9lA_
Description: poly(A) binding protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
mRNA binding 2.78281658065802 bayes_pls_golite062009
nucleic acid binding 2.51377464669599 bayes_pls_golite062009
poly(A) RNA binding 2.40208706397043 bayes_pls_golite062009
poly-purine tract binding 2.34978214792168 bayes_pls_golite062009
binding 2.12178506555766 bayes_pls_golite062009
RNA binding 1.38020034067888 bayes_pls_golite062009
single-stranded RNA binding 1.00503950757483 bayes_pls_golite062009
protein binding 0.856075580719879 bayes_pls_golite062009
ligase activity 0.38737123012383 bayes_pls_golite062009
catalytic activity 0.287695754348243 bayes_pls_golite062009
small conjugating protein ligase activity 0.109419310631115 bayes_pls_golite062009
ubiquitin-protein ligase activity 0.0911314408939872 bayes_pls_golite062009
eukaryotic initiation factor 4G binding 0.054315640496152 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [531-668] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VNPLLRNSQI SPPNSQIPIN SQTLSQAQPP AQSQTQQRVP VAYQNASLSS QQLYNLNGPS  60
   61 SANSQSQLLP QHTNGSVHSN FSYQSYHDES MLSAHNLNSA DLIYKSLSHS GLDDGLEQGL 120
  121 NRSLSGLDLQ NQNKKNLW

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.266 0.050 DNA damage checkpoint a.77.1 DEATH domain

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Created and Maintained by: Michael Riffle