YRC Public Data Repository - Protein Structure Prediction

Protein:	TILS_LISMO
Organism:	Listeria monocytogenes
Length:	648 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TILS_LISMO.

Description	E-value	Query Range	Subject Range
TILS_LISIN - Bifunctional protein TilS/HprT OS=Listeria innocua serovar 6a (strain CLIP 11262) GN=tilS/hprT PE=3 ... TILS_LISIN - Bifunctional protein tilS/hprT OS=Listeria innocua GN=tilS/hprT PE=3 SV=1	467.0	[0..1]	[648..1]
gi\|226222848, gi... - gi\|226222848\|ref\|YP_002756955.1\| hypothetical protein Lm4b_00217 [Listeria monocytogenes Clip81459],... gi\|47018468, gi\|... - gi\|47093161\|ref\|ZP_00230936.1\| conserved hypothetical protein/hypoxanthine phosphoribosyltransferase... gi\|21667249 - gi\|21667249\|gb\|AAM74001.1\|AF467001_2 YacA/HprT-like protein [Listeria monocytogenes] gi\|153200654, gi... - gi\|254933059\|ref\|ZP_05266418.1\| hypothetical protein LmonH_11532 [Listeria monocytogenes HPB2262], g...	466.0	[0..1]	[648..1]
TILS_LISMF - Bifunctional protein TilS/HprT OS=Listeria monocytogenes serotype 4b (strain F2365) GN=tilS/hprT PE=...	465.0	[0..1]	[648..1]
gi\|148566608, gi... - gi\|148654498\|ref\|YP_001274703.1\| hypoxanthine phosphoribosyltransferase [Roseiflexus sp. RS-1], gi\|1...	321.0	[0..1]	[646..1]
TILS_BACCR - tRNA(Ile)-lysidine synthase OS=Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 /...	272.0	[0..2]	[464..3]
gi\|228853800, gi... - gi\|228905860\|ref\|ZP_04069758.1\| tRNA(Ile)-lysidine synthase [Bacillus thuringiensis IBL 200], gi\|228... gi\|74490730, gi\|... - gi\|75761780\|ref\|ZP_00741716.1\| tRNA(Ile)-lysidine synthetase TilS [Bacillus thuringiensis serovar is... gi\|228860842, gi... - gi\|228898817\|ref\|ZP_04063100.1\| tRNA(Ile)-lysidine synthase [Bacillus thuringiensis IBL 4222], gi\|22... gi\|228796549, gi... - gi\|228963164\|ref\|ZP_04124334.1\| tRNA(Ile)-lysidine synthase [Bacillus thuringiensis serovar sotto st...	272.0	[0..2]	[464..7]
TILS_BACCZ - tRNA(Ile)-lysidine synthase OS=Bacillus cereus (strain ZK / E33L) GN=tilS PE=3 SV=1	272.0	[0..2]	[464..3]
TILS_BACC1 - tRNA(Ile)-lysidine synthase OS=Bacillus cereus (strain ATCC 10987 / NRS 248) GN=tilS PE=3 SV=1	271.0	[0..2]	[464..3]
gi\|47570187, gi\|... - gi\|47570187\|ref\|ZP_00240841.1\| cell cycle protein mesJ [Bacillus cereus G9241], gi\|47553131\|gb\|EAL11...	271.0	[0..2]	[464..3]
gi\|195991035, gi... - gi\|196036405\|ref\|ZP_03103802.1\| tRNA(Ile)-lysidine synthetase [Bacillus cereus W], gi\|195991035\|gb\|E... gi\|225862116, gi... - gi\|225862116\|ref\|YP_002747494.1\| tRNA(Ile)-lysidine synthetase [Bacillus cereus 03BB102], gi\|2257909... TILS_BACHK - tRNA(Ile)-lysidine synthase OS=Bacillus thuringiensis subsp. konkukian GN=tilS PE=3 SV=1 gi\|196047393, gi... - gi\|196047393\|ref\|ZP_03114606.1\| tRNA(Ile)-lysidine synthetase [Bacillus cereus 03BB108], gi\|19602179... gi\|196027396, gi... - gi\|196041776\|ref\|ZP_03109066.1\| tRNA(Ile)-lysidine synthetase [Bacillus cereus NVH0597-99], gi\|19602... TILS_BACHK - tRNA(Ile)-lysidine synthase OS=Bacillus thuringiensis subsp. konkukian (strain 97-27) GN=tilS PE=3 S... gi\|218539357, gi... - gi\|218901265\|ref\|YP_002449099.1\| tRNA(Ile)-lysidine synthetase [Bacillus cereus AH820], gi\|218539357...	271.0	[0..2]	[464..3]

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Predicted Domain #1

Region A:
Residues: [1-450]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDDTEKRVHK YIEKHDLIRS DDKLLVAVSG GPDSLALLHF LWNSNLVPKE AISVAHLNHQ  60
   61 LRENAAKEQR VVETFCERQG IPFYIEEVDI KSRAQSLQKG LEETARIVRY DFFEKVMAEK 120
  121 NINKLVLAHH ADDQIETILM RLVRGSASIG WSGIQPKREL KGGQAIRPFL PITKAEIIDY 180
  181 AQKHELAYEI DESNTSQEYT RNRYRAQLLP FLKQENPAVY SHFERFSEET SEDFQFLEAL 240
  241 ASDLLKKNLI KNGKQTTLLL SSFKNEANPL QRRAIHLLLR YLYNEDASFI TVNHIYQIIQ 300
  301 MIQSDNPSSS IDLPNKLIAN RAYDKLHFQF GEREAPSEFY HQLELNDRIE LDNKASIRLK 360
  361 LKSSVVQTNG LNGMLLDAEE ITLPLIVRNR VNGDRMTMKG QAGSKKLKDI FIDAKIPRQE 420
  421 RDKLPVITDY TGKILWVPGV KKSAYDREFS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	59.30103
Match:	1ni5A
Description:	Putative cell cycle protein MesJ, N-terminal domain; Putative cell cycle protein MesJ, middle and C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ligase activity, forming carbon-oxygen bonds	5.31600041149223	bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds	5.31600041149223	bayes_pls_golite062009
aminoacyl-tRNA ligase activity	5.31492510480447	bayes_pls_golite062009
phenylalanine-tRNA ligase activity	4.77782949872067	bayes_pls_golite062009
ligase activity	3.71561290487771	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	1.9422825865652	bayes_pls_golite062009
carbon-nitrogen ligase activity, with glutamine as amido-N-donor	1.77152913449838	bayes_pls_golite062009
GMP synthase (glutamine-hydrolyzing) activity	1.72090211279097	bayes_pls_golite062009
protein binding	1.04733916422551	bayes_pls_golite062009
catalytic activity	0.828867994386867	bayes_pls_golite062009
binding	0.705046204987053	bayes_pls_golite062009
DNA binding	0.413404324688042	bayes_pls_golite062009
nucleic acid binding	0.083007846379087	bayes_pls_golite062009
transferase activity	0.0776944314618701	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [451-648]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RSKKQYIIRY TRNIGGNESM HNDIQKVLIS EDELQEKIRE LGRELTTEYE GRNPLVVGVL  60
   61 KGATPFMTDL LKRVDTYLEM DFMDVSSYGN GTVSSGEVKI IKDLNASVEG RDVLVIEDII 120
  121 DSGRTLSYLV DLIKYRKAKS VKLVTLLDKP AGRNVEIEAD YVGFVVPNEF VVGYGLDYAE 180
  181 RYRNLPYIGI LKPEIYSE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	35.045757
Match:	1r3uA
Description:	Crystal Structure of Hypoxanthine-Guanine Phosphoribosyltransferase from Thermoanaerobacter tengcongensis
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
adenine phosphoribosyltransferase activity	4.07252508868782	bayes_pls_golite062009
transferase activity, transferring glycosyl groups	3.91023158228049	bayes_pls_golite062009
hypoxanthine phosphoribosyltransferase activity	3.89356447922614	bayes_pls_golite062009
transferase activity	3.88709784255536	bayes_pls_golite062009
nucleobase binding	2.70671399975507	bayes_pls_golite062009
purine binding	2.63033967717893	bayes_pls_golite062009
transferase activity, transferring pentosyl groups	2.53679639481311	bayes_pls_golite062009
uracil phosphoribosyltransferase activity	2.36237864658341	bayes_pls_golite062009
catalytic activity	2.30431811394775	bayes_pls_golite062009
amidophosphoribosyltransferase activity	1.6596316647688	bayes_pls_golite062009
ribose phosphate diphosphokinase activity	1.51875493459374	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.18942699821229	bayes_pls_golite062009
protein binding	1.02514711359042	bayes_pls_golite062009
adenine binding	0.817887117933035	bayes_pls_golite062009
diphosphotransferase activity	0.749909396904601	bayes_pls_golite062009
binding	0.644392905117932	bayes_pls_golite062009
transcription regulator activity	0.369893745269311	bayes_pls_golite062009
DNA binding	0.275043319532312	bayes_pls_golite062009
orotate phosphoribosyltransferase activity	0.148898393751978	bayes_pls_golite062009
nucleic acid binding	0.00921141240853085	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: