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View Structure Prediction Details

Protein: gi|190404894
Organism: Saccharomyces cerevisiae RM11-1a
Length: 463 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|190404894.

Description E-value Query
Range
Subject
Range
ODO2_YEAST - Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, m...
gi|190404894 - gi|190404894|gb|EDV08161.1| hypothetical protein SCRG_00372 [Saccharomyces cerevisiae RM11-1a]
KGD2 - Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase com...
0.0 [1..463] [1..463]
gi|227010100, gi... - gi|227082212|ref|YP_002810763.1| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succin...
gi|229507825, gi... - gi|229507825|ref|ZP_04397330.1| dihydrolipoamide succinyltransferase component (E2) of 2-oxoglutarat...
gi|9656634, gi|1... - gi|9656634|gb|AAF95232.1| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltrans...
gi|229343763, gi... - gi|229519074|ref|ZP_04408517.1| dihydrolipoamide succinyltransferase component (E2) of 2-oxoglutarat...
gi|229607370, gi... - gi|229607370|ref|YP_002878018.1| dihydrolipoamide succinyltransferase component (E2) of 2-oxoglutara...
gi|75829400, gi|... - gi|75829400|ref|ZP_00758704.1| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam...
gi|147675118, gi... - gi|75827393|ref|ZP_00756828.1| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam...
gi|121727380, gi... - gi|75814758|ref|ZP_00745311.1| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam...
gi|121586902, gi... - gi|121586902|ref|ZP_01676682.1| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny...
gi|124119054, gi... - gi|153222194|ref|ZP_01952973.1| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny...
gi|153818382, gi... - gi|153818382|ref|ZP_01971049.1| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny...
gi|11257428 - pir||A82121 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase VC2086 ...
gi|229351903, gi... - gi|229511938|ref|ZP_04401417.1| dihydrolipoamide succinyltransferase component (E2) of 2-oxoglutarat...
0.0 [72..462] [1..402]
gi|186697571, gi... - gi|186894545|ref|YP_001871657.1| dihydrolipoamide succinyltransferase [Yersinia pseudotuberculosis P...
gi|169751723, gi... - gi|170025189|ref|YP_001721694.1| dihydrolipoamide succinyltransferase [Yersinia pseudotuberculosis Y...
gi|165924674, gi... - gi|165924674|ref|ZP_02220506.1| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny...
gi|21959982, gi|... - gi|22126942|ref|NP_670365.1| dihydrolipoamide acetyltransferase [Yersinia pestis KIM], gi|21959982|g...
gi|166211260, gi... - gi|166211260|ref|ZP_02237295.1| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny...
gi|25286448 - pir||AB0137 dihydrolipoamide S-succinyltransferase (EC 2.3.1.61) [imported] - Yersinia pestis (strai...
gi|166011609, gi... - gi|166011609|ref|ZP_02232507.1| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny...
gi|51595492, gi|... - gi|51595492|ref|YP_069683.1| dihydrolipoamide acetyltransferase [Yersinia pseudotuberculosis IP 3295...
gi|166962232, gi... - gi|167419491|ref|ZP_02311244.1| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny...
gi|45435734, gi|... - gi|45440876|ref|NP_992415.1| dihydrolipoamide acetyltransferase [Yersinia pestis biovar Microtus str...
gi|167050555, gi... - gi|167399847|ref|ZP_02305365.1| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny...
gi|167468939 - gi|167468939|ref|ZP_02333643.1| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny...
gi|218928282, gi... - gi|218928282|ref|YP_002346157.1| dihydrolipoamide succinyltransferase [Yersinia pestis CO92], gi|161...
gi|167057125, gi... - gi|167424276|ref|ZP_02316029.1| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny...
gi|77636427, gi|... - gi|77636427|ref|ZP_00798501.1| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam...
gi|77632107, gi|... - gi|77632107|ref|ZP_00794693.1| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam...
gi|149291260, gi... - gi|149366886|ref|ZP_01888920.1| dihydrolipoamide succinyltransferase component of 2-oxoglutarate deh...
gi|145599848, gi... - gi|145599848|ref|YP_001163924.1| dihydrolipoamide acetyltransferase [Yersinia pestis Pestoides F], g...
Q66DA1|Q66DA1_YERPS - Dihydrolipoamide succinyltransferase component of 2-oxoglutar... - Yersinia pseudotuberculosis
gi|89105201, gi|... - gi|89105201|ref|ZP_01177725.1| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam...
gi|108806589, gi... - gi|108806589|ref|YP_650505.1| dihydrolipoamide acetyltransferase [Yersinia pestis Antiqua], gi|10877...
gi|229697416, gi... - gi|229841050|ref|ZP_04461209.1| dihydrolipoyltranssuccinase [Yersinia pestis biovar Orientalis str. ...
gi|229843154, gi... - gi|229843154|ref|ZP_04463300.1| dihydrolipoyltranssuccinase [Yersinia pestis biovar Orientalis str. ...
gi|229703876, gi... - gi|229893991|ref|ZP_04509177.1| dihydrolipoyltranssuccinase [Yersinia pestis Pestoides A], gi|229703...
gi|229903485, gi... - gi|229903485|ref|ZP_04518598.1| dihydrolipoyltranssuccinase [Yersinia pestis Nepal516], gi|229679255...
0.0 [71..462] [1..405]
gi|15602143, gi|... - gi|15602143|ref|NP_245215.1| hypothetical protein PM0278 [Pasteurella multocida subsp. multocida str...
0.0 [71..462] [1..402]
gi|73854728, gi|... - gi|74311251|ref|YP_309670.1| dihydrolipoamide acetyltransferase [Shigella sonnei Ss046], gi|73854728...
gi|168777543, gi... - gi|187767227|gb|EDU31071.1| dihydrolipoyllysine-residue succinyltransferase, E2 component of oxoglut...
gi|194421839, gi... - gi|83585342|ref|ZP_00923989.1| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam...
gi|189002966, gi... - gi|189002966|gb|EDU71952.1| dihydrolipoyllysine-residue succinyltransferase, E2 component of oxoglut...
gi|189372983, gi... - gi|189372983|gb|EDU91399.1| dihydrolipoyllysine-residue succinyltransferase, E2 component of oxoglut...
gi|189376474, gi... - gi|189376474|gb|EDU94890.1| dihydrolipoyllysine-residue succinyltransferase, E2 component of oxoglut...
gi|193070661, gi... - gi|75234495|ref|ZP_00718842.1| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam...
gi|170020929, gi... - gi|170020929|ref|YP_001725883.1| dihydrolipoamide succinyltransferase [Escherichia coli ATCC 8739], ...
gi|75511614, gi|... - gi|75511614|ref|ZP_00734265.1| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam...
gi|170080393, gi... - gi|170080393|ref|YP_001729713.1| dihydrolipoyltranssuccinase [Escherichia coli str. K-12 substr. DH1...
gi|75189748, gi|... - gi|75189748|ref|ZP_00703015.1| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam...
gi|170518735, gi... - gi|170681017|ref|YP_001742827.1| dihydrolipoyllysine-residue succinyltransferase, E2 component of ox...
gi|75229641, gi|... - gi|75229641|ref|ZP_00716178.1| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam...
gi|194417748, gi... - gi|194433983|ref|ZP_03066254.1| dihydrolipoyllysine-residue succinyltransferase, E2 component of oxo...
gi|13360210, gi|... - gi|15830006|ref|NP_308779.1| dihydrolipoamide succinyltransferase [Escherichia coli O157:H7 str. Sak...
gi|188015221, gi... - gi|188015221|gb|EDU53343.1| dihydrolipoyllysine-residue succinyltransferase, E2 component of oxoglut...
gi|168757180, gi... - gi|189355777|gb|EDU74196.1| dihydrolipoyllysine-residue succinyltransferase, E2 component of oxoglut...
gi|189365937, gi... - gi|189365937|gb|EDU84353.1| dihydrolipoyllysine-residue succinyltransferase, E2 component of oxoglut...
gi|1651322, gi|8... - gi|89107584|ref|AP_001364.1| dihydrolipoyltranssuccinase [Escherichia coli str. K-12 substr. W3110],...
gi|189363360, gi... - gi|189363360|gb|EDU81779.1| dihydrolipoyllysine-residue succinyltransferase, E2 component of oxoglut...
gi|218360021, gi... - gi|218553253|ref|YP_002386166.1| dihydrolipoamide succinyltransferase [Escherichia coli IAI1], gi|21...
gi|218369067, gi... - gi|218699081|ref|YP_002406710.1| dihydrolipoamide succinyltransferase [Escherichia coli IAI39], gi|2...
gi|254791873, gi... - gi|254791873|ref|YP_003076710.1| dihydrolipoyltranssuccinase [Escherichia coli O157:H7 str. TW14359]...
gi|253972697, gi... - gi|254160796|ref|YP_003043904.1| dihydrolipoamide acetyltransferase [Escherichia coli B str. REL606]...
gi|195939068 - gi|195939068|ref|ZP_03084450.1| dihydrolipoamide acetyltransferase [Escherichia coli O157:H7 str. EC...
gi|253325347, gi... - gi|254287584|ref|YP_003053332.1| dihydrolipoamide acetyltransferase [Escherichia coli BL21(DE3)], gi...
ODO2_ECOLI - Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (E...
gi|208725695, gi... - gi|208805894|ref|ZP_03248231.1| dihydrolipoyllysine-residue succinyltransferase, E2 component of oxo...
gi|251784215, gi... - gi|251784215|ref|YP_002998519.1| hypothetical protein B21_00675 [Escherichia coli BL21], gi|24237648...
ODO2_ECO57 - Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex OS...
gi|208815793, gi... - gi|208815793|ref|ZP_03256972.1| dihydrolipoyllysine-residue succinyltransferase, E2 component of oxo...
gi|238899991, gi... - gi|238899991|ref|YP_002925787.1| dihydrolipoyltranssuccinase [Escherichia coli BW2952], gi|238860764...
EG10980 - dihydrolipoyltranssuccinase / 2-oxoglutarate dehydrogenase, E2 component; dihydrolipoamide succinylt...
gi|208822873, gi... - gi|208822873|ref|ZP_03263191.1| dihydrolipoyllysine-residue succinyltransferase, E2 component of oxo...
gi|12513642, gi|... - gi|15800431|ref|NP_286443.1| dihydrolipoamide acetyltransferase [Escherichia coli O157:H7 EDL933], g...
gi|209397255, gi... - gi|209397255|ref|YP_002269350.1| dihydrolipoyllysine-residue succinyltransferase, E2 component of ox...
gi|209917977, gi... - gi|209917977|ref|YP_002292061.1| dihydrolipoamide succinyltransferase [Escherichia coli SE11], gi|20...
gi|215263817, gi... - gi|215485745|ref|YP_002328176.1| dihydrolipoamide succinyltransferase [Escherichia coli O127:H6 str....
gi|217322317, gi... - gi|217326096|ref|ZP_03442180.1| dihydrolipoyllysine-residue succinyltransferase, E2 component of oxo...
gi|124526818, gi... - gi|124526818|ref|ZP_01698700.1| 2-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinylt...
EG10980 - dihydrolipoyltranssuccinase / 2-oxoglutarate dehydrogenase, E2 component; dihydrolipoamide succinylt...
0.0 [71..462] [1..403]
DBT - dihydrolipoamide branched chain transacylase E2
HGNC:2698|MIM:24... - branched chain transacylase E2
gi|61359897, gi|... - gi|61359903|gb|AAX41784.1| dihydrolipoamide branched chain transacylase [synthetic construct], gi|61...
0.0 [9..462] [3..479]
ODO2_RICPR - Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex OS...
ODO2_RICPR - Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex OS...
0.0 [72..462] [1..399]
gi|15614768, gi|... - gi|15614768|ref|NP_243071.1| dihydrolipoamide acetyltransferase [Bacillus halodurans C-125], gi|1017...
gi|25286430 - pir||E83925 dihydrolipoamide succinyltransferase BH2205 [imported] - Bacillus halodurans (strain C-1...
0.0 [74..462] [2..409]

Back

Predicted Domain #1
Region A:
Residues: [1-70]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSRATRTAA AKSLVKSKVA RNVMAASFVK RHASTSLFKQ ANKVESLGSI YLSGKKISVA  60
   61 ANPFSITSNR 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.519 a.4.5 "Winged helix" DNA-binding domain
View Download 0.546 a.64.1 Saposin
View Download 0.503 d.74.2 C-terminal domain of arginine repressor
View Download 0.514 a.64.1 Saposin
View Download 0.459 a.101.1 Uteroglobin-like
View Download 0.454 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.442 a.4.5 "Winged helix" DNA-binding domain
View Download 0.439 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.435 a.159.2 FF domain
View Download 0.387 g.3.7 Scorpion toxin-like
View Download 0.380 a.57.1 Protein HNS-dependent expression A; HdeA
View Download 0.374 a.101.1 Uteroglobin-like
View Download 0.370 d.95.2 Homing endonucleases
View Download 0.365 a.101.1 Uteroglobin-like
View Download 0.357 a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.340 a.4.5 "Winged helix" DNA-binding domain
View Download 0.333 d.95.1 Glucose permease domain IIB
View Download 0.331 a.4.5 "Winged helix" DNA-binding domain
View Download 0.311 a.77.1 DEATH domain
View Download 0.308 a.2.7 tRNA-binding arm
View Download 0.305 a.4.5 "Winged helix" DNA-binding domain
View Download 0.301 d.26.3 Chitinase insertion domain
View Download 0.281 d.58.35 Pseudouridine synthase
View Download 0.279 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.276 a.4.1 Homeodomain-like
View Download 0.262 a.39.1 EF-hand
View Download 0.262 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.262 b.85.1 Type III antifreeze protein, AFP III
View Download 0.261 b.85.1 Type III antifreeze protein, AFP III
View Download 0.258 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.255 g.10.1 Hairpin loop containing domain-like
View Download 0.250 d.39.1 Dynein light chain 8 (DLC8)
View Download 0.248 f.15.1 Small-conductance potassium channel
View Download 0.246 d.95.1 Glucose permease domain IIB
View Download 0.240 a.4.5 "Winged helix" DNA-binding domain
View Download 0.239 d.95.1 Glucose permease domain IIB
View Download 0.236 a.77.1 DEATH domain
View Download 0.232 a.4.1 Homeodomain-like
View Download 0.228 a.77.1 DEATH domain
View Download 0.221 a.49.1 C-terminal domain of B transposition protein
View Download 0.218 a.70.1 N-terminal domain of the delta subunit of the F1F0-ATP synthase
View Download 0.215 d.68.3 SirA-like
View Download 0.214 a.4.1 Homeodomain-like

Predicted Domain #2
Region A:
Residues: [71-182]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FKSTSIEVPP MAESLTEGSL KEYTKNVGDF IKEDELLATI ETDKIDIEVN SPVSGTVTKL  60
   61 NFKPEDTVTV GEELAQVEPG EAPAEGSGES KPEPTEQAEP SQGVAARENS SE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 67.9897
Match: 1lab__
Description: Ipoyl domain of dihydrolipoamide acetyltransferase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [183-231]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ETASKKEAAP KKEAAPKKEV TEPKKADQPK KTVSKAQEPP VASNSFTPF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.09691
Match: 2pdd__
Description: E3/E1 binding domain of dihydrolipoyl acetyltransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
S-succinyltransferase activity 10.0778678835755 bayes_pls_golite062009
dihydrolipoyllysine-residue succinyltransferase activity 10.0778678835755 bayes_pls_golite062009
S-acyltransferase activity 9.57991961071442 bayes_pls_golite062009
succinyltransferase activity 6.58826720904067 bayes_pls_golite062009
acyltransferase activity 6.14362200989279 bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups 6.13552509992797 bayes_pls_golite062009
dihydrolipoamide S-acyltransferase activity 4.1573115612763 bayes_pls_golite062009
dihydrolipoyllysine-residue acetyltransferase activity 3.95619571226032 bayes_pls_golite062009
transferase activity, transferring acyl groups 3.91600160749755 bayes_pls_golite062009
S-acetyltransferase activity 3.80731268500197 bayes_pls_golite062009
carnitine O-acyltransferase activity 1.95284873022177 bayes_pls_golite062009
catalytic activity 1.51562638409295 bayes_pls_golite062009
pyruvate dehydrogenase activity 1.47989209806246 bayes_pls_golite062009
O-acyltransferase activity 1.33852311685118 bayes_pls_golite062009
acetyltransferase activity 1.12787027896966 bayes_pls_golite062009
transferase activity 1.08341671157927 bayes_pls_golite062009
binding 0.801074244553007 bayes_pls_golite062009
O-palmitoyltransferase activity 0.36133273832704 bayes_pls_golite062009
carnitine O-palmitoyltransferase activity 0.36133273832704 bayes_pls_golite062009
carnitine O-acetyltransferase activity 0.154650266774881 bayes_pls_golite062009
O-acetyltransferase activity 0.1424856707148 bayes_pls_golite062009
protein binding 0.00454070917775817 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [232-463]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PRTETRVKMN RMRLRIAERL KESQNTAASL TTFNEVDMSA LMEMRKLYKD EIIKKTGTKF  60
   61 GFMGLFSKAC TLAAKDIPAV NGAIEGDQIV YRDYTDISVA VATPKGLVTP VVRNAESLSV 120
  121 LDIENEIVRL SHKARDGKLT LEDMTGGTFT ISNGGVFGSL YGTPIINSPQ TAVLGLHGVK 180
  181 ERPVTVNGQI VSRPMMYLAL TYDHRLLDGR EAVTFLKTVK ELIEDPRKML LW

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 870.0
Match: 1c4tA_
Description: Dihydrolipoamide succinyltransferase
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle