YRC Public Data Repository - Protein Structure Prediction

Protein:	sdk-PF, sdk-PD, ...
Organism:	Drosophila melanogaster
Length:	2224 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for sdk-PF, sdk-PD, ....

Description	E-value	Query Range	Subject Range
sdk-PC - The gene sidekick is referred to in FlyBase by the symbol Dmel\sdk (CG5227, FBgn0021764). It is a pr...	1456.0	[0..1]	[2224..1]

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Predicted Domain #1

Region A:
Residues: [1-454]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLKSAASSLR RRRPKTTITA TLAIEMPSQP KLASLLAVLV LLCYCDSCFF CYADANLQQQ  60
   61 NSIVQQQQLQ APRFTTHPSS SGSIVSEGST KILQCHALGY PQPTYRWLKD GVPVGDFSSS 120
  121 QFYRFHSTRR EDAGSYQCIA RNDAGSIFSE KSDVVVAYMG IFENTTEGRL TVISGHPAIF 180
  181 DMPPIESIPV PSVMWQSEDG PLNYDIKYAF THANQLIILS ADENDRKGYR AKAINTQLGK 240
  241 EESSAFVHLN VSGDPYIEVA PEIIVRPQDV KVKVGTGVVE LQCIANARPL HELETLWLKD 300
  301 GLAVETAGVR HTLNDPWNRT LALLQANSSH SGEYTCQVRL RSGGYPAVSA SARLQILEPP 360
  361 LFFTPMRAET FGEFGGQVQL TCDVVGEPTP QVKWFRNAES VDAHIESGRY TLNTDNTLVI 420
  421 KKLILDDAAM FQCLAINEAG ENSASTWLRV KTSA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	68.154902
Match:	1cs6A
Description:	Axonin-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
fibroblast growth factor 1 binding	6.68503380812062	bayes_pls_golite062009
olfactory receptor activity	4.21057154107121	bayes_pls_golite062009
receptor activity	4.00123250685257	bayes_pls_golite062009
transmembrane receptor activity	3.81769911097805	bayes_pls_golite062009
peptide antigen binding	3.67780971105726	bayes_pls_golite062009
fibroblast growth factor binding	3.54458347746523	bayes_pls_golite062009
fibroblast growth factor receptor activity	3.20458334492494	bayes_pls_golite062009
binding	3.17641566810715	bayes_pls_golite062009
molecular transducer activity	3.10913345555941	bayes_pls_golite062009
signal transducer activity	3.10913345555941	bayes_pls_golite062009
structural constituent of muscle	3.0670143338313	bayes_pls_golite062009
telethonin binding	2.7640623319209	bayes_pls_golite062009
IgG binding	2.62006935586983	bayes_pls_golite062009
actinin binding	2.36862691336591	bayes_pls_golite062009
growth factor binding	2.28613301180608	bayes_pls_golite062009
protein binding	2.22855404705168	bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity	1.52958974617075	bayes_pls_golite062009
cell adhesion molecule binding	1.36789541796983	bayes_pls_golite062009
protein kinase activity	1.36635494500222	bayes_pls_golite062009
transmembrane receptor protein kinase activity	1.30657787244536	bayes_pls_golite062009
antigen binding	1.21831175352585	bayes_pls_golite062009
myosin light chain kinase activity	1.17845072849922	bayes_pls_golite062009
G-protein coupled receptor activity	1.02428106476324	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.02286631988334	bayes_pls_golite062009
alpha-actinin binding	0.972937283833051	bayes_pls_golite062009
kinase activity	0.929878054374821	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.878595022643164	bayes_pls_golite062009
protein complex binding	0.83543827718565	bayes_pls_golite062009
immunoglobulin binding	0.76611788332163	bayes_pls_golite062009
collagen binding	0.729893120256353	bayes_pls_golite062009
peptide binding	0.729048089532569	bayes_pls_golite062009
receptor binding	0.632627479346393	bayes_pls_golite062009
cytokine binding	0.631436442105379	bayes_pls_golite062009
integrin binding	0.599569390248921	bayes_pls_golite062009
protein serine/threonine kinase activity	0.564762108830441	bayes_pls_golite062009
nucleic acid binding	0.518011841154552	bayes_pls_golite062009
IgG receptor activity	0.50231877534761	bayes_pls_golite062009
myosin heavy chain binding	0.49788128784685	bayes_pls_golite062009
immunoglobulin receptor activity	0.45286767588665	bayes_pls_golite062009
cytokine receptor activity	0.34165331857492	bayes_pls_golite062009
protein tyrosine kinase activity	0.318890055375093	bayes_pls_golite062009
transcription regulator activity	0.316848380982695	bayes_pls_golite062009
DNA binding	0.304320681250924	bayes_pls_golite062009
cell surface binding	0.213817211551667	bayes_pls_golite062009
transferase activity	0.053007146193305	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [455-753]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PIMELPPQNV TALDGKDATI SCRAVGSPNP NITWIYNETQ LVDISSRVQI LESGDLLISN  60
   61 IRSVDAGLYI CVRANEAGSV KGEAYLSVLV RTQIIQPPVD TTVLLGLTAT LQCKVSSDPS 120
  121 VPYNIDWYRE GQSSTPISNS QRIGVQADGQ LEIQAVRASD VGSYACVVTS PGGNETRAAR 180
  181 LSVIELPFPP SNVKVERLPE PQQRSINVSW TPGFDGNSPI SKFIIQRREV SELEKFVGPV 240
  241 PDPLLNWITE LSNVSADQRW ILLENLKAAT VYQFRVSAVN RVGEGSPSEP SNVVELPQE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	36.522879
Match:	2nziA
Description:	No description for 2nziA was found.

Predicted Domain #3

Region A:
Residues: [754-856]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 APSGPPVGFV GSARSMSEII TQWQPPLEEH RNGQILGYIL RYRLFGYNNV PWSYQNITNE  60
   61 AQRNFLIQEL ITWKDYIVQI AAYNNMGVGV YTEGSKIKTK EGV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	13.522879
Match:	2edxA
Description:	No description for 2edxA was found.

Predicted Domain #4

Region A:
Residues: [857-1061]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PEAPPTNVKV EAINSTAARC RWTPPNPQQI NGINQGYKIQ AWQRRLIDGE WRDIERRMKT  60
   61 VPPSLIDPLA EQTAILGGLE KFTEYNISVL CFTDPGDGVA SSQVAVMTMD DVPDEVTGLH 120
  121 FDDVSDRSVK VLWAPPRASN GILTGYTVRY QVKDRPDTLK SFNLTADDTE LTVNQLQATT 180
  181 HYWFEIVAWT RVGSGIPKTA TIQSG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	22.69897
Match:	1qg3A
Description:	Integin beta-4 subunit
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [1062-1167]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VEPVLPHAPT ALALSNIEAF SVVLQFTPGF DGNSSITKWK VEGQTARNMT WFTICEINDP  60
   61 DAETLTVTGL VPFTQYRLRL SASNVVGSSK PSEATKDFQT IQARPK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	10.221849
Match:	1wisA
Description:	Solution structure of the fifth FNIII domain from human KIAA1514 protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transmembrane receptor activity	4.81256300373074	bayes_pls_golite062009
ankyrin binding	4.69755754047169	bayes_pls_golite062009
receptor activity	4.66147271961356	bayes_pls_golite062009
cytokine binding	4.43581512268554	bayes_pls_golite062009
cytokine receptor activity	4.08668869714207	bayes_pls_golite062009
growth factor binding	4.06808996928726	bayes_pls_golite062009
structural constituent of muscle	3.84784419485732	bayes_pls_golite062009
molecular transducer activity	3.69234048247377	bayes_pls_golite062009
signal transducer activity	3.69234048247377	bayes_pls_golite062009
protein binding	3.24522318184038	bayes_pls_golite062009
binding	3.12471204223368	bayes_pls_golite062009
interleukin-2 binding	2.38131482184802	bayes_pls_golite062009
cell adhesion molecule binding	2.32179186005318	bayes_pls_golite062009
prolactin receptor activity	2.15346920063421	bayes_pls_golite062009
ciliary neurotrophic factor receptor activity	2.15011619378442	bayes_pls_golite062009
peptide hormone binding	2.12033076929638	bayes_pls_golite062009
axon guidance receptor activity	2.01367445237355	bayes_pls_golite062009
telethonin binding	1.93341916149844	bayes_pls_golite062009
growth hormone receptor activity	1.71208292022464	bayes_pls_golite062009
polysaccharide binding	1.69642470905172	bayes_pls_golite062009
interleukin-6 receptor activity	1.66250899275539	bayes_pls_golite062009
interleukin-6 binding	1.66250899275539	bayes_pls_golite062009
glycosaminoglycan binding	1.6158868405814	bayes_pls_golite062009
interleukin-11 receptor activity	1.57103867592521	bayes_pls_golite062009
interleukin-11 binding	1.57103867592521	bayes_pls_golite062009
myosin light chain kinase activity	1.49217960276915	bayes_pls_golite062009
protein kinase activity	1.42856560840953	bayes_pls_golite062009
heparin binding	1.40418056272895	bayes_pls_golite062009
receptor binding	1.31676259534833	bayes_pls_golite062009
oncostatin-M receptor activity	1.27120658254426	bayes_pls_golite062009
leukemia inhibitory factor receptor activity	1.27120658254426	bayes_pls_golite062009
actinin binding	1.25223034107956	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.15899955607967	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.12142142875217	bayes_pls_golite062009
kinase activity	1.11027658115625	bayes_pls_golite062009
ciliary neurotrophic factor binding	1.02710126648804	bayes_pls_golite062009
interleukin-7 binding	0.992216255634359	bayes_pls_golite062009
peptide binding	0.92031154055894	bayes_pls_golite062009
protein dimerization activity	0.86564366658585	bayes_pls_golite062009
interleukin-2 receptor activity	0.817385502041609	bayes_pls_golite062009
cell surface binding	0.792329562040096	bayes_pls_golite062009
protein serine/threonine kinase activity	0.703490254739121	bayes_pls_golite062009
collagen binding	0.688581536921572	bayes_pls_golite062009
identical protein binding	0.564711394496051	bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity	0.554350228628563	bayes_pls_golite062009
transcription activator activity	0.529736394173061	bayes_pls_golite062009
nucleic acid binding	0.522840770355105	bayes_pls_golite062009
hormone binding	0.49524185948356	bayes_pls_golite062009
transcription regulator activity	0.470959482317512	bayes_pls_golite062009
transmembrane receptor protein kinase activity	0.46168925186147	bayes_pls_golite062009
transferase activity	0.432850266451294	bayes_pls_golite062009
DNA binding	0.310798383307903	bayes_pls_golite062009
pattern binding	0.30071837231983	bayes_pls_golite062009
transcription factor binding	0.210682741845199	bayes_pls_golite062009
protein heterodimerization activity	0.1430595594485	bayes_pls_golite062009
protein homodimerization activity	0.116391819218123	bayes_pls_golite062009
integrin binding	0.0873424694168858	bayes_pls_golite062009
cytokine receptor binding	0.0682540643558203	bayes_pls_golite062009
growth factor activity	0.0477008672713168	bayes_pls_golite062009

Predicted Domain #6

Region A:
Residues: [1168-1315]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HPPFNVTVRA MSAQQLRVRW IPLQQTEWYG NPRGYNISYK QLVKTPGTIK YVPRSVVIED  60
   61 HTANSHVLDS LEEWTLYEVK MNACNDVGCS KESDTAVERT REAVPSYGPL DVQANATSST 120
  121 TVVVQWGEVP RQHRNGQIDG YKVFYAAA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	14.39794
Match:	1gh7A
Description:	Common beta-chain in the GM-CSF, IL-3 and IL-5 receptors
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transmembrane receptor activity	4.81256300373074	bayes_pls_golite062009
ankyrin binding	4.69755754047169	bayes_pls_golite062009
receptor activity	4.66147271961356	bayes_pls_golite062009
cytokine binding	4.43581512268554	bayes_pls_golite062009
cytokine receptor activity	4.08668869714207	bayes_pls_golite062009
growth factor binding	4.06808996928726	bayes_pls_golite062009
structural constituent of muscle	3.84784419485732	bayes_pls_golite062009
molecular transducer activity	3.69234048247377	bayes_pls_golite062009
signal transducer activity	3.69234048247377	bayes_pls_golite062009
protein binding	3.24522318184038	bayes_pls_golite062009
binding	3.12471204223368	bayes_pls_golite062009
interleukin-2 binding	2.38131482184802	bayes_pls_golite062009
cell adhesion molecule binding	2.32179186005318	bayes_pls_golite062009
prolactin receptor activity	2.15346920063421	bayes_pls_golite062009
ciliary neurotrophic factor receptor activity	2.15011619378442	bayes_pls_golite062009
peptide hormone binding	2.12033076929638	bayes_pls_golite062009
axon guidance receptor activity	2.01367445237355	bayes_pls_golite062009
telethonin binding	1.93341916149844	bayes_pls_golite062009
growth hormone receptor activity	1.71208292022464	bayes_pls_golite062009
polysaccharide binding	1.69642470905172	bayes_pls_golite062009
interleukin-6 receptor activity	1.66250899275539	bayes_pls_golite062009
interleukin-6 binding	1.66250899275539	bayes_pls_golite062009
glycosaminoglycan binding	1.6158868405814	bayes_pls_golite062009
interleukin-11 receptor activity	1.57103867592521	bayes_pls_golite062009
interleukin-11 binding	1.57103867592521	bayes_pls_golite062009
myosin light chain kinase activity	1.49217960276915	bayes_pls_golite062009
protein kinase activity	1.42856560840953	bayes_pls_golite062009
heparin binding	1.40418056272895	bayes_pls_golite062009
receptor binding	1.31676259534833	bayes_pls_golite062009
oncostatin-M receptor activity	1.27120658254426	bayes_pls_golite062009
leukemia inhibitory factor receptor activity	1.27120658254426	bayes_pls_golite062009
actinin binding	1.25223034107956	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.15899955607967	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.12142142875217	bayes_pls_golite062009
kinase activity	1.11027658115625	bayes_pls_golite062009
ciliary neurotrophic factor binding	1.02710126648804	bayes_pls_golite062009
interleukin-7 binding	0.992216255634359	bayes_pls_golite062009
peptide binding	0.92031154055894	bayes_pls_golite062009
protein dimerization activity	0.86564366658585	bayes_pls_golite062009
interleukin-2 receptor activity	0.817385502041609	bayes_pls_golite062009
cell surface binding	0.792329562040096	bayes_pls_golite062009
protein serine/threonine kinase activity	0.703490254739121	bayes_pls_golite062009
collagen binding	0.688581536921572	bayes_pls_golite062009
identical protein binding	0.564711394496051	bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity	0.554350228628563	bayes_pls_golite062009
transcription activator activity	0.529736394173061	bayes_pls_golite062009
nucleic acid binding	0.522840770355105	bayes_pls_golite062009
hormone binding	0.49524185948356	bayes_pls_golite062009
transcription regulator activity	0.470959482317512	bayes_pls_golite062009
transmembrane receptor protein kinase activity	0.46168925186147	bayes_pls_golite062009
transferase activity	0.432850266451294	bayes_pls_golite062009
DNA binding	0.310798383307903	bayes_pls_golite062009
pattern binding	0.30071837231983	bayes_pls_golite062009
transcription factor binding	0.210682741845199	bayes_pls_golite062009
protein heterodimerization activity	0.1430595594485	bayes_pls_golite062009
protein homodimerization activity	0.116391819218123	bayes_pls_golite062009
integrin binding	0.0873424694168858	bayes_pls_golite062009
cytokine receptor binding	0.0682540643558203	bayes_pls_golite062009
growth factor activity	0.0477008672713168	bayes_pls_golite062009

Predicted Domain #7

Region A:
Residues: [1316-1839]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DRGQQVLHKT IPNNATFTTT LTELKKYVVY HVQVLAYTRL GNGALSTPPI RVQTFEDTPG  60
   61 VPSNVSFPDV SLTMARIIWD VPVDPNGKIL AYQVTYTLNG SAMLNYSREF PPSDRTFRAT 120
  121 ELLPGKYYSF SCTAQTRLGW GKIATALVYT TNNRERPQAP SVPQISRSQI QAHQITFSWT 180
  181 PGRDGFAPLR YYTVEMRENE GRWQPLPERV DPSLSSFTAV GLRPYMTYQF RIQATNDLGP 240
  241 SAFSRESVIV RTLPAAPAVG VGGLKVVPIT TTSVRVQWSA LETALWNGDA STGGYRILYQ 300
  301 QLSDFPTALQ STPKTDVHGI NENSVVLSDL QQDRNYEIVV LPFNSQGPGP ATPPAAVYVG 360
  361 EAVPTGEPRA VDAAPISSTE VRLLWKPPKQ SMQNGDILGY KIYYLVTYSP QALEPGRKWE 420
  421 EEIEVVSATA TSHSLVFLDK FTEYRIQLLA FNPAGDGPRS APITVKTLPG VPSAPLHLRF 480
  481 SDITMQSLEV TWDPPKFLNG EILGYLVTYE TTEENEKFSK QVKQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	36.39794
Match:	2v5yA
Description:	No description for 2v5yA was found.

Predicted Domain #8

Region A:
Residues: [1840-1986]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KVSNTTLRVQ NLEEEVTYTF TVRAQTSVDY GPGISENVTT GPQDGSPVAP RDLILTKTLS  60
   61 SVEMHWINGP SGRGPILGYL IEAKKRDDSR WTKIEQTRKG MMQDFTVSYH ILMPSTAYTF 120
  121 RVIAYNRYGI SFPVYSKDSI LTPSKLH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	26.39794
Match:	1fnhA
Description:	Fibronectin, different Fn3 modules
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transmembrane receptor activity	4.81256300373074	bayes_pls_golite062009
ankyrin binding	4.69755754047169	bayes_pls_golite062009
receptor activity	4.66147271961356	bayes_pls_golite062009
cytokine binding	4.43581512268554	bayes_pls_golite062009
cytokine receptor activity	4.08668869714207	bayes_pls_golite062009
growth factor binding	4.06808996928726	bayes_pls_golite062009
structural constituent of muscle	3.84784419485732	bayes_pls_golite062009
molecular transducer activity	3.69234048247377	bayes_pls_golite062009
signal transducer activity	3.69234048247377	bayes_pls_golite062009
protein binding	3.24522318184038	bayes_pls_golite062009
binding	3.12471204223368	bayes_pls_golite062009
interleukin-2 binding	2.38131482184802	bayes_pls_golite062009
cell adhesion molecule binding	2.32179186005318	bayes_pls_golite062009
prolactin receptor activity	2.15346920063421	bayes_pls_golite062009
ciliary neurotrophic factor receptor activity	2.15011619378442	bayes_pls_golite062009
peptide hormone binding	2.12033076929638	bayes_pls_golite062009
axon guidance receptor activity	2.01367445237355	bayes_pls_golite062009
telethonin binding	1.93341916149844	bayes_pls_golite062009
growth hormone receptor activity	1.71208292022464	bayes_pls_golite062009
polysaccharide binding	1.69642470905172	bayes_pls_golite062009
interleukin-6 receptor activity	1.66250899275539	bayes_pls_golite062009
interleukin-6 binding	1.66250899275539	bayes_pls_golite062009
glycosaminoglycan binding	1.6158868405814	bayes_pls_golite062009
interleukin-11 receptor activity	1.57103867592521	bayes_pls_golite062009
interleukin-11 binding	1.57103867592521	bayes_pls_golite062009
myosin light chain kinase activity	1.49217960276915	bayes_pls_golite062009
protein kinase activity	1.42856560840953	bayes_pls_golite062009
heparin binding	1.40418056272895	bayes_pls_golite062009
receptor binding	1.31676259534833	bayes_pls_golite062009
oncostatin-M receptor activity	1.27120658254426	bayes_pls_golite062009
leukemia inhibitory factor receptor activity	1.27120658254426	bayes_pls_golite062009
actinin binding	1.25223034107956	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.15899955607967	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.12142142875217	bayes_pls_golite062009
kinase activity	1.11027658115625	bayes_pls_golite062009
ciliary neurotrophic factor binding	1.02710126648804	bayes_pls_golite062009
interleukin-7 binding	0.992216255634359	bayes_pls_golite062009
peptide binding	0.92031154055894	bayes_pls_golite062009
protein dimerization activity	0.86564366658585	bayes_pls_golite062009
interleukin-2 receptor activity	0.817385502041609	bayes_pls_golite062009
cell surface binding	0.792329562040096	bayes_pls_golite062009
protein serine/threonine kinase activity	0.703490254739121	bayes_pls_golite062009
collagen binding	0.688581536921572	bayes_pls_golite062009
identical protein binding	0.564711394496051	bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity	0.554350228628563	bayes_pls_golite062009
transcription activator activity	0.529736394173061	bayes_pls_golite062009
nucleic acid binding	0.522840770355105	bayes_pls_golite062009
hormone binding	0.49524185948356	bayes_pls_golite062009
transcription regulator activity	0.470959482317512	bayes_pls_golite062009
transmembrane receptor protein kinase activity	0.46168925186147	bayes_pls_golite062009
transferase activity	0.432850266451294	bayes_pls_golite062009
DNA binding	0.310798383307903	bayes_pls_golite062009
pattern binding	0.30071837231983	bayes_pls_golite062009
transcription factor binding	0.210682741845199	bayes_pls_golite062009
protein heterodimerization activity	0.1430595594485	bayes_pls_golite062009
protein homodimerization activity	0.116391819218123	bayes_pls_golite062009
integrin binding	0.0873424694168858	bayes_pls_golite062009
cytokine receptor binding	0.0682540643558203	bayes_pls_golite062009
growth factor activity	0.0477008672713168	bayes_pls_golite062009

Predicted Domain #9

Region A:
Residues: [1987-2100]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LEYGYLQHKP FYRQTWFMVS LAATSIVIIV MVIAVLCVKS KSYKYKQEAQ KTLEESMAMS  60
   61 IDERQELALE LYRSRHGVGT GTLNSVGTLR SGTLGTLGRK STSRPPPGVH LGKS

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #10

Region A:
Residues: [2101-2224]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPRPSPASVA YHSDEESLKC YDENPDDSSV TEKPSEVSSS EASQHSESEN ESVRSDPHSF  60
   61 VNHYANVNDS LRQSWKKTKP VRNYSSYTDS EPEGSAVMSL NGGQIIVNNM ARSRAPLPGF 120
  121 SSFV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	10.69897
Match:	2crzA
Description:	Solution structure of the fifth FNIII domain of human fibronectin type III domain containing protein 3a
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transmembrane receptor activity	4.81256300373074	bayes_pls_golite062009
ankyrin binding	4.69755754047169	bayes_pls_golite062009
receptor activity	4.66147271961356	bayes_pls_golite062009
cytokine binding	4.43581512268554	bayes_pls_golite062009
cytokine receptor activity	4.08668869714207	bayes_pls_golite062009
growth factor binding	4.06808996928726	bayes_pls_golite062009
structural constituent of muscle	3.84784419485732	bayes_pls_golite062009
molecular transducer activity	3.69234048247377	bayes_pls_golite062009
signal transducer activity	3.69234048247377	bayes_pls_golite062009
protein binding	3.24522318184038	bayes_pls_golite062009
binding	3.12471204223368	bayes_pls_golite062009
interleukin-2 binding	2.38131482184802	bayes_pls_golite062009
cell adhesion molecule binding	2.32179186005318	bayes_pls_golite062009
prolactin receptor activity	2.15346920063421	bayes_pls_golite062009
ciliary neurotrophic factor receptor activity	2.15011619378442	bayes_pls_golite062009
peptide hormone binding	2.12033076929638	bayes_pls_golite062009
axon guidance receptor activity	2.01367445237355	bayes_pls_golite062009
telethonin binding	1.93341916149844	bayes_pls_golite062009
growth hormone receptor activity	1.71208292022464	bayes_pls_golite062009
polysaccharide binding	1.69642470905172	bayes_pls_golite062009
interleukin-6 receptor activity	1.66250899275539	bayes_pls_golite062009
interleukin-6 binding	1.66250899275539	bayes_pls_golite062009
glycosaminoglycan binding	1.6158868405814	bayes_pls_golite062009
interleukin-11 receptor activity	1.57103867592521	bayes_pls_golite062009
interleukin-11 binding	1.57103867592521	bayes_pls_golite062009
myosin light chain kinase activity	1.49217960276915	bayes_pls_golite062009
protein kinase activity	1.42856560840953	bayes_pls_golite062009
heparin binding	1.40418056272895	bayes_pls_golite062009
receptor binding	1.31676259534833	bayes_pls_golite062009
oncostatin-M receptor activity	1.27120658254426	bayes_pls_golite062009
leukemia inhibitory factor receptor activity	1.27120658254426	bayes_pls_golite062009
actinin binding	1.25223034107956	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.15899955607967	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.12142142875217	bayes_pls_golite062009
kinase activity	1.11027658115625	bayes_pls_golite062009
ciliary neurotrophic factor binding	1.02710126648804	bayes_pls_golite062009
interleukin-7 binding	0.992216255634359	bayes_pls_golite062009
peptide binding	0.92031154055894	bayes_pls_golite062009
protein dimerization activity	0.86564366658585	bayes_pls_golite062009
interleukin-2 receptor activity	0.817385502041609	bayes_pls_golite062009
cell surface binding	0.792329562040096	bayes_pls_golite062009
protein serine/threonine kinase activity	0.703490254739121	bayes_pls_golite062009
collagen binding	0.688581536921572	bayes_pls_golite062009
identical protein binding	0.564711394496051	bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity	0.554350228628563	bayes_pls_golite062009
transcription activator activity	0.529736394173061	bayes_pls_golite062009
nucleic acid binding	0.522840770355105	bayes_pls_golite062009
hormone binding	0.49524185948356	bayes_pls_golite062009
transcription regulator activity	0.470959482317512	bayes_pls_golite062009
transmembrane receptor protein kinase activity	0.46168925186147	bayes_pls_golite062009
transferase activity	0.432850266451294	bayes_pls_golite062009
DNA binding	0.310798383307903	bayes_pls_golite062009
pattern binding	0.30071837231983	bayes_pls_golite062009
transcription factor binding	0.210682741845199	bayes_pls_golite062009
protein heterodimerization activity	0.1430595594485	bayes_pls_golite062009
protein homodimerization activity	0.116391819218123	bayes_pls_golite062009
integrin binding	0.0873424694168858	bayes_pls_golite062009
cytokine receptor binding	0.0682540643558203	bayes_pls_golite062009
growth factor activity	0.0477008672713168	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions:

Predicted functions:

Predicted functions:

Predicted functions: