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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Spt2. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 7 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CKA1
  • protein kinase CK2 complex
  • G2/M transition of mitotic cell cycle
  • G1/S transition of mitotic cell cycle
  • flocculation via cell wall protein-carbohydrate interaction
  • protein amino acid phosphorylation
  • response to DNA damage stimulus
  • regulation of transcription from RNA polymerase III promoter
  • regulation of transcription from RNA polymerase I promoter
  • cellular ion homeostasis
  • protein kinase CK2 activity
  • CKA2
  • protein kinase CK2 complex
  • G2/M transition of mitotic cell cycle
  • G1/S transition of mitotic cell cycle
  • flocculation via cell wall protein-carbohydrate interaction
  • protein amino acid phosphorylation
  • response to DNA damage stimulus
  • regulation of transcription from RNA polymerase III promoter
  • regulation of transcription from RNA polymerase I promoter
  • cellular ion homeostasis
  • protein kinase CK2 activity
  • CKB1
  • protein kinase CK2 complex
  • G2/M transition of mitotic cell cycle
  • G1/S transition of mitotic cell cycle
  • flocculation via cell wall protein-carbohydrate interaction
  • protein amino acid phosphorylation
  • response to DNA damage stimulus
  • regulation of transcription from RNA polymerase III promoter
  • regulation of transcription from RNA polymerase I promoter
  • cellular ion homeostasis
  • protein kinase CK2 regulator activity
  • IMD2
  • cytoplasm
  • GTP biosynthetic process
  • IMP dehydrogenase activity
  • NOP1
  • nuclear outer membrane
  • nucleolus
  • ribosome
  • small nucleolar ribonucleoprotein complex
  • rRNA modification
  • RNA methylation
  • maturation of SSU-rRNA
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • snoRNA 3'-end processing
  • methyltransferase activity
  • SAH1
  • cytoplasm
  • methionine metabolic process
  • selenocysteine metabolic process
  • adenosylhomocysteinase activity
  • SPT2
  • nucleus
  • negative regulation of transcription from RNA polymerase II promoter
  • RNA polyadenylation
  • chromatin organization
  • RNA elongation from RNA polymerase II promoter
  • DNA binding
  • DNA secondary structure binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    protein kinase CK2 complex 3.3722E-9 7 4 3 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    regulation of transcription from RNA polymerase I promoter 3.3722E-9 7 4 3 6292
    regulation of transcription from RNA polymerase III promoter 2.9465E-8 7 7 3 6292
    flocculation via cell wall protein-carbohydrate interaction 1.0088E-7 7 10 3 6292
    flocculation 1.3864E-7 7 11 3 6292
    G2/M transition of mitotic cell cycle 3.0439E-6 7 29 3 6292
    transcription from RNA polymerase I promoter 3.3805E-6 7 30 3 6292
    transcription from RNA polymerase III promoter 6.9973E-6 7 38 3 6292
    G1/S transition of mitotic cell cycle 1.6164E-5 7 50 3 6292
    interphase of mitotic cell cycle 1.1888E-4 7 97 3 6292
    interphase 1.1888E-4 7 97 3 6292
    cellular nitrogen compound metabolic process 1.3822E-4 7 1770 7 6292
    protein amino acid phosphorylation 1.4218E-4 7 103 3 6292
    nitrogen compound metabolic process 1.5014E-4 7 1791 7 6292
    cellular chemical homeostasis 2.1845E-4 7 119 3 6292
    cellular ion homeostasis 2.1845E-4 7 119 3 6292
    cellular homeostasis 2.2394E-4 7 120 3 6292
    chemical homeostasis 2.4096E-4 7 123 3 6292
    ion homeostasis 2.4096E-4 7 123 3 6292
    regulation of transcription, DNA-dependent 3.1451E-4 7 358 4 6292
    regulation of RNA metabolic process 3.3186E-4 7 363 4 6292
    multi-organism process 3.7631E-4 7 143 3 6292
    regulation of transcription 4.1249E-4 7 384 4 6292
    regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 5.5642E-4 7 415 4 6292
    regulation of nitrogen compound metabolic process 5.616E-4 7 416 4 6292
    regulation of gene expression 7.2752E-4 7 445 4 6292
    phosphorylation 7.2841E-4 7 179 3 6292
    regulation of macromolecule biosynthetic process 7.9889E-4 7 456 4 6292
    RNA 3'-end processing 8.9439E-4 7 42 2 6292
    regulation of cellular biosynthetic process 9.1156E-4 7 472 4 6292
    regulation of biosynthetic process 9.1897E-4 7 473 4 6292
    regulation of macromolecule metabolic process 1.0353E-3 7 488 4 6292
    selenocysteine metabolic process 1.1125E-3 7 1 1 6292
    selenium metabolic process 1.1125E-3 7 1 1 6292
    transcription, DNA-dependent 1.162E-3 7 503 4 6292
    RNA biosynthetic process 1.2065E-3 7 508 4 6292
    regulation of primary metabolic process 1.2617E-3 7 514 4 6292
    RNA metabolic process 1.2754E-3 7 954 5 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.3005E-3 7 1566 6 6292
    regulation of cellular metabolic process 1.4794E-3 7 536 4 6292
    phosphorus metabolic process 1.4941E-3 7 229 3 6292
    phosphate metabolic process 1.4941E-3 7 229 3 6292
    regulation of metabolic process 1.5978E-3 7 547 4 6292
    response to DNA damage stimulus 1.6304E-3 7 236 3 6292
    transcription 1.6538E-3 7 552 4 6292
    macromolecule modification 1.8549E-3 7 569 4 6292
    mitotic cell cycle 2.0396E-3 7 255 3 6292
    GTP biosynthetic process 2.224E-3 7 2 1 6292
    cellular response to stress 2.9533E-3 7 290 3 6292
    primary metabolic process 4.3588E-3 7 2896 7 6292
    gene expression 5.0816E-3 7 1283 5 6292
    post-translational protein modification 5.3413E-3 7 357 3 6292
    snoRNA 3'-end processing 5.552E-3 7 5 1 6292
    cellular metabolic process 6.026E-3 7 3033 7 6292
    cell cycle phase 6.1847E-3 7 376 3 6292
    cellular response to stimulus 6.3249E-3 7 379 3 6292
    regulation of cellular process 6.4862E-3 7 796 4 6292
    regulation of biological process 7.3628E-3 7 824 4 6292
    snoRNA processing 7.7654E-3 7 7 1 6292
    GTP metabolic process 7.7654E-3 7 7 1 6292
    homeostatic process 7.7826E-3 7 408 3 6292
    nucleic acid metabolic process 7.9545E-3 7 1415 5 6292
    metabolic process 7.9792E-3 7 3157 7 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    protein kinase CK2 activity 1.0611E-6 7 2 2 6292
    obsolete_molecular_function 4.2818E-5 7 69 3 6292
    trialkylsulfonium hydrolase activity 1.1125E-3 7 1 1 6292
    adenosylhomocysteinase activity 1.1125E-3 7 1 1 6292
    protein kinase CK2 regulator activity 2.224E-3 7 2 1 6292
    hydrolase activity, acting on ether bonds 3.3344E-3 7 3 1 6292
    IMP dehydrogenase activity 3.3344E-3 7 3 1 6292
    DNA secondary structure binding 9.9746E-3 7 9 1 6292

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