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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Lsm2. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 9 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ADE5,7
  • cytoplasm
  • purine nucleotide biosynthetic process
  • 'de novo' IMP biosynthetic process
  • purine base metabolic process
  • phosphoribosylamine-glycine ligase activity
  • phosphoribosylformylglycinamidine cyclo-ligase activity
  • DHH1
  • cytoplasm
  • cytoplasmic mRNA processing body
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
  • deadenylation-dependent decapping of nuclear-transcribed mRNA
  • protein binding
  • RNA helicase activity
  • LSM2
  • U4/U6 x U5 tri-snRNP complex
  • nucleolus
  • U6 snRNP
  • small nucleolar ribonucleoprotein complex
  • mRNA catabolic process
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • LSM4
  • U4/U6 x U5 tri-snRNP complex
  • nucleolus
  • U6 snRNP
  • small nucleolar ribonucleoprotein complex
  • mRNA catabolic process
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • LSM7
  • U4/U6 x U5 tri-snRNP complex
  • nucleolus
  • U6 snRNP
  • small nucleolar ribonucleoprotein complex
  • telomere maintenance
  • mRNA catabolic process
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • LSM8
  • nucleus
  • U4/U6 x U5 tri-snRNP complex
  • U6 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • PAT1
  • cytoplasmic mRNA processing body
  • deadenylation-dependent decapping of nuclear-transcribed mRNA
  • chromosome segregation
  • regulation of translational initiation
  • molecular_function
  • PRP24
  • U6 snRNP
  • spliceosome assembly
  • assembly of spliceosomal tri-snRNP
  • nucleic acid binding
  • nucleotide binding
  • U6 snRNA binding
  • RNA binding
  • snRNA binding
  • RPN6
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • structural molecule activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    U6 snRNP 7.0723E-13 9 11 5 6292
    small nuclear ribonucleoprotein complex 1.0466E-8 9 63 5 6292
    U4/U6 x U5 tri-snRNP complex 6.822E-8 9 32 4 6292
    ribonucleoprotein complex 7.2713E-7 9 514 7 6292
    small nucleolar ribonucleoprotein complex 1.149E-4 9 72 3 6292
    macromolecular complex 1.4222E-4 9 1635 8 6292
    cytoplasmic mRNA processing body 1.8916E-4 9 15 2 6292
    nucleolus 2.6889E-3 9 211 3 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    mRNA metabolic process 1.5717E-9 9 213 7 6292
    mRNA catabolic process 1.6681E-8 9 69 5 6292
    RNA catabolic process 3.5472E-8 9 80 5 6292
    nuclear mRNA splicing, via spliceosome 1.0447E-7 9 99 5 6292
    RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 1.099E-7 9 100 5 6292
    RNA splicing, via transesterification reactions 1.5461E-7 9 107 5 6292
    cellular macromolecule catabolic process 3.9855E-7 9 265 6 6292
    RNA splicing 4.4384E-7 9 132 5 6292
    macromolecule catabolic process 7.3826E-7 9 294 6 6292
    mRNA processing 1.0222E-6 9 156 5 6292
    cellular catabolic process 5.6289E-6 9 415 6 6292
    catabolic process 1.5934E-5 9 496 6 6292
    RNA metabolic process 4.9072E-5 9 954 7 6292
    RNA processing 8.0571E-5 9 380 5 6292
    deadenylation-dependent decapping of nuclear-transcribed mRNA 9.9377E-5 9 11 2 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.0193E-4 9 1566 8 6292
    cellular nitrogen compound metabolic process 2.6198E-4 9 1770 8 6292
    nitrogen compound metabolic process 2.8682E-4 9 1791 8 6292
    nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 6.2672E-4 9 27 2 6292
    nucleic acid metabolic process 6.6981E-4 9 1415 7 6292
    primary metabolic process 9.2081E-4 9 2896 9 6292
    nuclear-transcribed mRNA catabolic process 1.245E-3 9 38 2 6292
    cellular metabolic process 1.3966E-3 9 3033 9 6292
    cellular macromolecule metabolic process 1.8315E-3 9 2285 8 6292
    metabolic process 2.004E-3 9 3157 9 6292
    macromolecule metabolic process 2.2547E-3 9 2349 8 6292
    spliceosomal snRNP assembly 2.859E-3 9 2 1 6292
    assembly of spliceosomal tri-snRNP 2.859E-3 9 2 1 6292
    gene expression 3.3789E-3 9 1283 6 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    RNA binding 6.8127E-5 9 367 5 6292
    nucleic acid binding 1.1464E-3 9 666 5 6292
    phosphoribosylformylglycinamidine cyclo-ligase activity 1.4304E-3 9 1 1 6292
    U6 snRNA binding 1.4304E-3 9 1 1 6292
    phosphoribosylamine-glycine ligase activity 1.4304E-3 9 1 1 6292
    binding 3.5377E-3 9 1294 6 6292
    cyclo-ligase activity 4.2857E-3 9 3 1 6292
    snRNA binding 7.1338E-3 9 5 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle