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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Lsm8. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 11 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
APA1
  • nucleus
  • cytoplasm
  • nucleotide metabolic process
  • bis(5'-nucleosyl)-tetraphosphatase activity
  • GAR1
  • box H/ACA snoRNP complex
  • nuclear outer membrane
  • nucleolus
  • small nucleolar ribonucleoprotein complex
  • ribosome biogenesis
  • RNA binding
  • LSM2
  • U4/U6 x U5 tri-snRNP complex
  • nucleolus
  • U6 snRNP
  • small nucleolar ribonucleoprotein complex
  • mRNA catabolic process
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • LSM8
  • nucleus
  • U4/U6 x U5 tri-snRNP complex
  • U6 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • QCR2
  • mitochondrion
  • mitochondrial respiratory chain complex III
  • mitochondrial electron transport, ubiquinol to cytochrome c
  • aerobic respiration
  • ubiquinol-cytochrome-c reductase activity
  • RPN12
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • RPN8
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • molecular_function
  • RRP42
  • cytoplasmic exosome (RNase complex)
  • nuclear exosome (RNase complex)
  • nuclear outer membrane
  • mRNA catabolic process
  • 3'-5'-exoribonuclease activity
  • SMB1
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • TIF6
  • nucleus
  • cytoplasm
  • nuclear outer membrane
  • nucleolus
  • ribosomal subunit export from nucleus
  • ribosomal large subunit biogenesis
  • processing of 27S pre-rRNA
  • ribosomal large subunit binding
  • YGL117W
  • cellular_component
  • biological_process
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    U4/U6 x U5 tri-snRNP complex 1.9183E-5 11 32 3 6292
    proteasome regulatory particle, lid subcomplex 1.241E-4 11 10 2 6292
    small nuclear ribonucleoprotein complex 1.491E-4 11 63 3 6292
    U6 snRNP 1.5154E-4 11 11 2 6292
    nuclear outer membrane 3.7586E-4 11 86 3 6292
    nuclear membrane 5.3581E-4 11 97 3 6292
    proteasome regulatory particle 6.8913E-4 11 23 2 6292
    proteasome accessory complex 6.8913E-4 11 23 2 6292
    macromolecular complex 1.5504E-3 11 1635 8 6292
    proteasome complex 3E-3 11 48 2 6292
    outer membrane 3.1067E-3 11 178 3 6292
    organelle outer membrane 3.1067E-3 11 178 3 6292
    box H/ACA snoRNP complex 3.4937E-3 11 2 1 6292
    nuclear envelope 4.2616E-3 11 199 3 6292
    nucleolus 5.0257E-3 11 211 3 6292
    nuclear part 5.935E-3 11 1103 6 6292
    nuclear membrane-endoplasmic reticulum network 6.5547E-3 11 232 3 6292
    small nucleolar ribonucleoprotein complex 6.6441E-3 11 72 2 6292
    envelope 8.5756E-3 11 505 4 6292
    organelle envelope 8.5756E-3 11 505 4 6292
    ribonucleoprotein complex 9.1283E-3 11 514 4 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    mRNA metabolic process 3.4939E-4 11 213 4 6292
    nuclear mRNA splicing, via spliceosome 5.6891E-4 11 99 3 6292
    RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 5.8594E-4 11 100 3 6292
    RNA splicing, via transesterification reactions 7.1442E-4 11 107 3 6292
    cellular macromolecule catabolic process 8.0284E-4 11 265 4 6292
    macromolecule catabolic process 1.1871E-3 11 294 4 6292
    RNA splicing 1.3165E-3 11 132 3 6292
    mRNA processing 2.131E-3 11 156 3 6292
    cellular catabolic process 4.2414E-3 11 415 4 6292
    mRNA catabolic process 6.1157E-3 11 69 2 6292
    catabolic process 8.046E-3 11 496 4 6292
    RNA catabolic process 8.1516E-3 11 80 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ribosomal large subunit binding 1.7483E-3 11 1 1 6292
    RNA binding 2.7066E-3 11 367 4 6292
    bis(5'-nucleosyl)-tetraphosphatase activity 5.2364E-3 11 3 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle