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View Protein Complex Details

Complex Overview

From Publication: Gavin A.C. et al. (2006) Proteome survey reveals modularity of the yeast cell machinery. Nature. 2006 Mar 30;440(7084):631-6. Epub 2006 Jan 22.
Notes: From the published set of protein complexes (core proteins only)
Complex Size: 12 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CSL4
  • cytoplasmic exosome (RNase complex)
  • nuclear exosome (RNase complex)
  • nuclear outer membrane
  • response to exogenous dsRNA
  • mRNA catabolic process
  • 3'-5'-exoribonuclease activity
  • DIS3
  • cytoplasmic exosome (RNase complex)
  • nuclear exosome (RNase complex)
  • mitochondrion
  • nuclear outer membrane
  • mRNA catabolic process
  • polyadenylation-dependent ncRNA catabolic process
  • 3'-5'-exoribonuclease activity
  • MTR3
  • cytoplasmic exosome (RNase complex)
  • nuclear exosome (RNase complex)
  • nuclear outer membrane
  • mRNA catabolic process
  • 3'-5'-exoribonuclease activity
  • RRP4
  • cytoplasmic exosome (RNase complex)
  • nuclear exosome (RNase complex)
  • nuclear outer membrane
  • mRNA catabolic process
  • 3'-5'-exoribonuclease activity
  • RNA binding
  • RRP40
  • cytoplasmic exosome (RNase complex)
  • nuclear exosome (RNase complex)
  • nuclear outer membrane
  • ribosome assembly
  • mRNA catabolic process
  • 3'-5'-exoribonuclease activity
  • RNA binding
  • RRP42
  • cytoplasmic exosome (RNase complex)
  • nuclear exosome (RNase complex)
  • nuclear outer membrane
  • mRNA catabolic process
  • 3'-5'-exoribonuclease activity
  • RRP43
  • cytoplasmic exosome (RNase complex)
  • nuclear exosome (RNase complex)
  • nuclear outer membrane
  • mRNA catabolic process
  • 3'-5'-exoribonuclease activity
  • RRP45
  • cytoplasmic exosome (RNase complex)
  • nuclear exosome (RNase complex)
  • nuclear outer membrane
  • mRNA catabolic process
  • 3'-5'-exoribonuclease activity
  • RRP46
  • cytoplasmic exosome (RNase complex)
  • nuclear exosome (RNase complex)
  • nuclear outer membrane
  • mRNA catabolic process
  • 3'-5'-exoribonuclease activity
  • RRP6
  • nuclear exosome (RNase complex)
  • nuclear outer membrane
  • ribosome biogenesis
  • mRNA catabolic process
  • polyadenylation-dependent ncRNA catabolic process
  • 3'-5'-exoribonuclease activity
  • SKI6
  • cytoplasmic exosome (RNase complex)
  • nuclear exosome (RNase complex)
  • nuclear outer membrane
  • response to exogenous dsRNA
  • mRNA catabolic process
  • 3'-5'-exoribonuclease activity
  • SKI7
  • cytoplasm
  • exosome (RNase complex)
  • response to exogenous dsRNA
  • mRNA catabolic process
  • protein binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    exosome (RNase complex) 2.2882E-34 12 16 12 6292
    nuclear exosome (RNase complex) 1.0773E-30 12 15 11 6292
    cytoplasmic exosome (RNase complex) 1.6361E-28 12 12 10 6292
    nuclear outer membrane 1.9108E-20 12 86 11 6292
    nuclear membrane 7.7564E-20 12 97 11 6292
    outer membrane 8.0038E-17 12 178 11 6292
    organelle outer membrane 8.0038E-17 12 178 11 6292
    nuclear envelope 2.8145E-16 12 199 11 6292
    nuclear membrane-endoplasmic reticulum network 1.5772E-15 12 232 11 6292
    endomembrane system 6.4449E-13 12 398 11 6292
    envelope 8.9615E-12 12 505 11 6292
    organelle envelope 8.9615E-12 12 505 11 6292
    membrane part 1.7624E-10 12 662 11 6292
    organelle membrane 2.8663E-10 12 692 11 6292
    protein complex 1.1559E-9 12 1137 12 6292
    nuclear part 4.6507E-8 12 1103 11 6292
    macromolecular complex 9.1989E-8 12 1635 12 6292
    membrane 1.1395E-7 12 1198 11 6292
    nucleus 3.4695E-5 12 2041 11 6292
    organelle part 1.1283E-4 12 2282 11 6292
    intracellular organelle part 1.1283E-4 12 2282 11 6292
    cytoplasmic part 2.4627E-3 12 2482 10 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    mRNA catabolic process 1.1083E-24 12 69 12 6292
    RNA catabolic process 7.5747E-24 12 80 12 6292
    mRNA metabolic process 1.6695E-18 12 213 12 6292
    cellular macromolecule catabolic process 2.445E-17 12 265 12 6292
    macromolecule catabolic process 8.7191E-17 12 294 12 6292
    cellular catabolic process 5.8339E-15 12 415 12 6292
    catabolic process 5.089E-14 12 496 12 6292
    RNA metabolic process 1.3916E-10 12 954 12 6292
    nucleic acid metabolic process 1.6138E-8 12 1415 12 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 5.4733E-8 12 1566 12 6292
    response to exogenous dsRNA 1.8476E-7 12 7 3 6292
    response to dsRNA 1.8476E-7 12 7 3 6292
    cellular nitrogen compound metabolic process 2.3908E-7 12 1770 12 6292
    nitrogen compound metabolic process 2.7555E-7 12 1791 12 6292
    cellular macromolecule metabolic process 5.1661E-6 12 2285 12 6292
    macromolecule metabolic process 7.2022E-6 12 2349 12 6292
    primary metabolic process 8.9282E-5 12 2896 12 6292
    polyadenylation-dependent RNA catabolic process 9.2781E-5 12 8 2 6292
    polyadenylation-dependent ncRNA catabolic process 9.2781E-5 12 8 2 6292
    cellular metabolic process 1.5563E-4 12 3033 12 6292
    metabolic process 2.5194E-4 12 3157 12 6292
    response to organic substance 1.9237E-3 12 137 3 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    3'-5'-exoribonuclease activity 1.0659E-27 12 23 11 6292
    exoribonuclease activity 6.088E-27 12 26 11 6292
    exoribonuclease activity, producing 5'-phosphomonoesters 6.088E-27 12 26 11 6292
    exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 2.2517E-25 12 34 11 6292
    3'-5' exonuclease activity 3.2833E-25 12 35 11 6292
    exonuclease activity 1.0481E-23 12 46 11 6292
    ribonuclease activity 1.0673E-17 12 149 11 6292
    nuclease activity 2.8145E-16 12 199 11 6292
    hydrolase activity, acting on ester bonds 1.1598E-13 12 341 11 6292
    hydrolase activity 5.8014E-9 12 911 11 6292
    catalytic activity 6.0184E-5 12 2150 11 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle